The Basics
What is Tuberculin?
Used in the diagnosis of tuberculosis.
Brand names for Tuberculin
Aplisol
How Tuberculin is classified
Antigens, Purified Protein Derivative
Tuberculin During Pregnancy
Tuberculin pregnancy category
Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Tuberculin while pregnant
Animal reproduction studies have not been conducted with Aplisol. It is also not known whether Aplisol can cause fetal harm when administered to a pregnant woman or can affect the reproduction capacity. Aplisol should be given to a pregnant woman only if clearly needed. However, the risk of unrecognized tuberculosis and the postpartum contact between a mother with active disease and an infant leaves the infant in grave danger of tuberculosis and complications such as tuberculous meningitis. Although there have not been any reported adverse effects upon the fetus recognized as being due to tuberculosis skin testing, the prescribing physician will want to consider if the potential benefits outweigh the possible risks for performing the tuberculin test on a pregnant woman or a woman of childbearing age, particularly in certain high risk populations. Tuberculin skin testing is considered valid and safe throughout pregnancy.3
Taking Tuberculin While Breastfeeding
What are recommendations for lactation if you're taking Tuberculin?
There is no reason to withhold breastfeeding after tuberculosis skin testing or to avoid skin testing in nursing mothers.
Maternal / infant drug levels
There is no reason to withhold breastfeeding after tuberculosis skin testing or to avoid skin testing in nursing mothers.
Possible effects of Tuberculin on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Tuberculin
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Martinez-Cairo Cueto S, Alasio-Chavez C, Davila Velasquez JR. [In vitro transfer of immunity against PPD with dialyzable extract of leukocytes from human colostrum]. Rev Alerg. 1992;39:126-32. PMID: 1492196
2. Schlesinger JJ, Covelli HD. Evidence for transmission of lymphocyte responses to tuberculin by breast-feeding. Lancet. 1977;2:529-32. PMID: 95733
3. Masters PL. Maternal transmission of skin sensitivity to tuberculin. Lancet. 1982;2:276-7. PMID: 6124704
4. Keller MA, Rodgriguez AL, Alvarez S et al. Transfer of tuberculin immunity from mother to infant. Pediatr Res.1987;22:277-81. PMID: 3658548
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.