The Basics
What is Ziprasidone?
Used to treat certain mental and mood disorders like schizophrenia and bipolar disorder and can decrease hallucinations.
Brand names for Ziprasidone
Geodon
How Ziprasidone is classified
Antipsychotic Agents
Ziprasidone During Pregnancy
Ziprasidone pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Ziprasidone while pregnant
Advise pregnant women to notify their healthcare provider if they become pregnant or intend to become pregnant during treatment with GEODON. Advise patients that GEODON may cause extrapyramidal and/or withdrawal symptoms (agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress, and feeding disorder) in a neonate. Advise patients that there is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to GEODON during pregnancy [see Use In Specific Populations].
Taking Ziprasidone While Breastfeeding
What are recommendations for lactation if you're taking Ziprasidone?
Because there is little published experience with ziprasidone during breastfeeding, other antipsychotic agents are preferred, especially while nursing a newborn or preterm infant.[1]
Maternal / infant drug levels
Because there is little published experience with ziprasidone during breastfeeding, other antipsychotic agents are preferred, especially while nursing a newborn or preterm infant.[1]
Possible effects of Ziprasidone on milk supply
Prolactin elevation has occurred during ziprasidone treatment,[4][5][6][7][8][9] and galactorrhea has been reported, often in adolescents.[4][5][6][7][10][11] However, prolactin elevation might be more transient and less severe than with phenothiazines.[12][13][14] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Possible alternatives to Ziprasidone
Haloperidol, Olanzapine, Quetiapine, Risperidone.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Uguz F. Second-generation antipsychotics during the lactation period: A comparative systematic review on infant safety. J Clin Psychopharmacol. 2016;36:244-52. PMID: 27028982
2. Schlotterbeck P, Saur R, Hiemke C et al. Low concentration of ziprasidone in human milk: a case report. Int J Neuropsychopharmacol. 2009;12:437-8. PMID: 19203410
3. Werremeyer A. Ziprasidone and citalopram use in pregnancy and lactation in a woman with psychotic depression. Am J Psychiatry. 2009;166:1298. Letter. PMID: 19884241
4. Jordan MP. Ziprasidone-associated galactorrhea in a female teenager. J Am Acad Child Adolesc Psychiatry. 2003;42(1):4-5. Letter. PMID: 12500070
5. Kopecek M, Bares M, Mohr P. Ziprasidone-induced galactorrhea: a case report. Neuro Endocrinol Lett. 2005;26:69-70. PMID: 15726024
6. Ramadan M, Khan A, Preskorn S. D2-blockade and possible ziprasidone-induced galactorrhea. Int Clin Psychopharmacol. 2005;20:113-4. PMID: 15729088
7. Saldana SN, Delgado SV. Ziprasidone-associated galactorrhea in an adolescent female. J Child Adolesc Psychopharmacol. 2007;17:259-60. PMID: 17489723
8. Ginsberg DL. Ziprasidone-induced galactorrhea. Prim Psychiatr. 2003;April:22-3.
9. Ginsberg DL. Ziprasidone-induced hyperprolactinemia. Prim Psychiatry. 2004;11:26-7.
10. Myers WT. A lacting adolescent on atypical antipsychotics: A case report of an emerging challenge. J Invest Med. 2014;62:485. Abstract.
11. Raza S, Haq F. Ziprasidone-Induced galactorrhea in an adolescent female: A case report. Prim Care Companion J Clin Psych. 2010;12.
12. Maguire GA. Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences. J Clin Psychiatry. 2002;63(suppl 4):56-62. PMID: 11913677
13. Goodnick PJ, Rodriguez L, Santana O. Antipsychotics: impact on prolactin levels. Expert Opin Pharmacother. 2002;3:1381-91. PMID: 12387684
14. Weiden PJ, Daniel DG, Simpson G, Romano SJ. Improvement in indices of health status in outpatients with schizophrenia switched to ziprasidone. J Clin Psychopharmacol. 2003;23:595-600. PMID: 14624190
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
