The Basics On Benzyl Salicylate

What is Benzyl Salicylate?

A volatile fragrance chemical with a sweet, floral odor used to impart scent to cosmetic products and perfumes.

What are other names for Benzyl Salicylate?

2-HYDROXY- PHENYLMETHYL ESTER BENZOIC ACID, 2-HYDROXYBENZOIC ACID, BENZYL ESTER, BENZOIC ACID, 2-HYDROXY-, PHENYLMETHYL ESTER, BENZOIC ACID, 2HYDROXY, PHENYLMETHYL ESTER, BENZYL 2-HYDROXYBENZOATE, BENZYL ESTER 2-HYDROXYBENZOIC ACID, BENZYL ESTER SALICYLIC ACID, BENZYL O-HYDROXYBENZOATE, BENZYL SALICYLATE, PHENYLMETHYL 2-HYDROXYBENZOATE, PHENYLMETHYL ESTER BENZOIC ACID, 2-HYDROXY-, and SALICYLIC ACID, BENZYL ESTER

What is Benzyl Salicylate used for?

Benzyl salicylate is an ester formed by the esterification of salicylic acid with benzyl alcohol. It is a volatile fragrance chemical with a sweet, floral odor used to impart scent to cosmetic products and perfumes. Benzyl salicylate is found in cloves and can be isolated from essential oils e. g. Dianthus caryophyllus, Populus, Primula species Fixative in perfumes and flavorings. Benzyl salicylate is a salicylic acid benzyl ester, a chemical compound most frequently used in cosmetics. It appears as an almost colorless liquid and is rather faint or odorless in nature.1

How Benzyl Salicylate is classified

Fragrance: Synthetic and Fragrant Plant Extracts

Recommendations for using Benzyl Salicylate during pregnancy and breastfeeding

Avoid

 

Benzyl Salicylate During Pregnancy

What we know about using Benzyl Salicylate while pregnant or breastfeeding

Limited information available.

Oral Following a short term screening assessment described above, Sprague–Dawley rats were administered Benzyl Salicylate dissolved in corn oil once daily via gavage at levels of 0 (control), 30, 100, or 300 mg/kg/day using a dosing volume of 5 mL/kg.21 Males (n = 12 per group) were dosed for 14 days prior to mating and a further 28 days during mating, giving a total of 42 dosing days. Females in the mating group (n = 12 per treatment group) were dosed for 14 days prior to mating and then through mating and gestation until postpartum day 4, giving a total of 41 to 46 days of dosing, while females in the non-mating group (n=10 per treatment group) were dosed for 42 days. In total, 5 males and 5 non-mated females in the control and high-dose groups were left untreated for 14 days as a recovery period. In terms of reproductive/developmental toxicity, Benzyl Salicylate was not found to have any effects on fertility or implantation, or to cause severe maternal toxicity. However, marked embryotoxicity was observed in the form of early embryonic resorption in the 300 mg/kg/day treatment group, and dead offspring exhibited neural tube defects. Based on the screening assessment, the D-value (which is the Derived No Effects Levels (DNEL) in the European Regulation on REACH for repeated-dose toxicity corresponds to hazard class of 0.05 mg/kg/day, and the hazard class was determined to be “Class 3” (0.005 < D < 0.05). Based on the developmental toxicity, the lowest-observable-adverse-effect-level (LOAEL) of Benzyl Salicylate was 30 mg/kg/day, the D-value was calculated as 0.003 mg/kg/day and the hazard class for reproductive/developmental toxicity was determined to be “Class 2” (D < 0.005).

General safety info about Benzyl Salicylate from CIR

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of Benzyl Salicylate, which is reported to function as a fragrance ingredient and light stabilizer. The Panel reviewed the available data to determine the safety of this ingredient. The Panel concluded that Benzyl Salicylate is safe in cosmetics in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating and non-sensitizing, which may be based on a quantitative risk assessment (QRA).

Use this, not that!

Coming soon!

Products where you might find Benzyl Salicylate

Erborian CC Cream Radiance Color Corrector Broad Spectrum SPF25; Erborian CC Cream Radiance Color Corrector Broad Spectrum SPF25 Mini

 

 

 

List of References

General sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/

1. Benzyl salicylate ‚Äì Pharmacology and Biochemistry. PubChem- Open Chemistry Database. https://pubchem.ncbi.nlm.nih.gov/compound/benzyl_salicylate#section=Pharmacology-and-Biochemistry. Published 2018. Accessed September 2018. 2. Rastogi S, Heydorn S, Johansen J, Basketter D. Fragrance chemicals in domestic and occupational products. Contact Dermatitis. 2001;45(4):221-225. [PubMed] 3. Schnuch A, Uter W, Geier J, Lessmann H, Frosch P. Sensitization to 26 fragrances to be labelled according to current European regulation. Results of the IVDK and review of the literature. Contact Dermatitis. 2007;57(1):1-10. [PubMed] 4. Benzyl salicylate. EWG’s Skin Deep Cosmetic Database. https://www.ewg.org/skindeep/ingredient/700701/BENZYL_SALICYLATE/#.W7B3aGgzZhE. Published 2018. Accessed October 2018.

 

 

Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.

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