C13-14 Isoparaffin

The Basics On C13-14 Isoparaffin

What is C13-14 Isoparaffin?

A petroleum-derived ingredient whose wax-like texture functions as a thickening or gelling agent.

What are other names for C13-14 Isoparaffin?

ALKANES, C13-14-ISO-, C13-14 ISOPARAFFIN, C13-14-ISO- ALKANES, and ISOALKANES

What is C13-14 Isoparaffin used for?

How C13-14 Isoparaffin is classified

Texture Enhancer

Recommendations for using C13-14 Isoparaffin during pregnancy and breastfeeding

Limited data suggests no known risk

 

C13-14 Isoparaffin During Pregnancy

What we know about using C13-14 Isoparaffin while pregnant or breastfeeding

Limited information available.

Isopar G (C10-11 Isoparaffin) Reportedly, in a reproductive toxicity study, mated Sprague Dawley rats were exposed (inhalation, 6 h/d) to 0, 300, or 900 ppm Isopar G on days 6 to 15 of gestation.6 The dams were killed on day 21 of gestation, and fetuses were examined for external, visceral, and skeletal malformations. Compared to controls, there were no changes in the following parameters: resorptions, fetal size, sex distribution, and fetal alterations. Isopar G was neither fetotoxic nor teratogenic to rats at concentrations up to 900 ppm. These data were referenced as unpublished data from Exxon Company, and the number of animals per dose group was not included. Isooctane The embryotoxic and/or teratogenic potential of Isopar C (85% isooctane) was evaluated using groups of 20 mated Sprague-Dawley rats.7 Two groups were exposed to the test substance at concentrations of 400 and 1200 ppm, respectively, on days 6 to 15 of gestation. A negative control (air exposed) group and a positive control (acetylsalicylic acid orally, 400 mg/kg per d) group were included. Female rats were killed on day 21 of gestation, and fetuses were evaluated for external, soft-tissue, and skeletal malformations. Compared to controls, rats exposed to 400 or 1200 ppm Isopar C had a significantly higher implantation efficiency. However, this finding was not indicative of a treatment-related adverse effect. Also, in these 2 groups, there were no treatment-related effects on the following: uterine implantation data, fetal size or sex distribution data, or fetal external, soft-tissue, or skeletal examination data. The incidence of fetuses with ossification variations was significantly increased in the 1200 ppm exposure group. However, the types and incidences of ossification variations were generally comparable to observations in the control group. It was concluded that Isopar C was neither embryotoxic nor teratogenic in Sprague-Dawley rats exposed at concentrations of 400 and 1200 ppm. The incidence of fetal malformations was increased in the positive control group.7 According to a chemical safety report that was prepared in accordance with the REACH regulation, no reproductive effects are expected after exposure to isooctane.51 This expectation is based on negative results for hexane, a structurally related substance, in reproductive and developmental toxicity studies. Isododecane Results from a subchronic inhalation toxicity study on isododecane, summarized earlier in the report text, indicated increased relative weights of the gonads in male and female rats exposed (inhalation) to 1800 ppm isododecane for 13 weeks.43 The test protocol and other study results are included in the Subchronic Inhalation Toxicity section. In a chemical safety report that was prepared in accordance with the REACH regulation, data on hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclic, and aromatics (2 to 25%) were among the data used to evaluate the reproductive toxicity of isododecane in rats and data on hydrocarbons, C9-C11, isoalkanes, cyclic, and <2% aromatics were among the data used to evaluate the developmental toxicity of isododecane in rats.37 Neither reproductive nor developmental toxic effects were observed. Isohexadecane and Isoeicosane Similarly, in chemical safety reports that were prepared in accordance with the REACH regulation, data on hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclic, and <2% aromatics were among the data used to evaluate the developmental toxicity of isoeicosane.58,59 The NOAEL was >1000 mg/kg per d, and there were no signs of maternal toxicity or treatment-related adverse effects on fetal development in rats.

General safety info about C13-14 Isoparaffin from CIR

The safety of isoparaffins as used in cosmetic products is reviewed in this safety assessment. These ingredients function mostly as solvents and also function as emollients in the 0001% to 90% concentration range. The Cosmetic Ingredient Review (CIR) Expert Panel has reviewed relevant animal and clinical data and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment.

Use this, not that!

Products where you might find C13-14 Isoparaffin

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