Calcium Pca

The Basics On Calcium Pca

What is Calcium Pca?

Calcium PCA is the calcium salt of PCA (pyrrolidone carboxylic acid), which is a key component of skin’s natural moisturizing factor, or NMF.

What are other names for Calcium Pca?

5-OXO CALCIUM SALT L-PROLINE, CALCIUM BIS(5-OXO-L-PROLINATE), CALCIUM PCA, CALCIUM PIDOLATE, CALCIUM SALT L-PROLINE, 5-OXO, and L-PROLINE, 5-OXO, CALCIUM SALT

What is Calcium Pca used for?

Calcium PCA is the calcium salt of PCA (pyrrolidone carboxylic acid), which is a key component of skin’s natural moisturizing factor, or NMF. … Topically, calcium PCA helps replenish skin’s barrier and works as a humectant to draw and hold moisture in skin’s uppermost layers.

How Calcium Pca is classified

Hydration, Skin-Replenishing

Recommendations for using Calcium Pca during pregnancy and breastfeeding

Limited data suggests no known risk

 

Calcium Pca During Pregnancy

What we know about using Calcium Pca while pregnant or breastfeeding

Limited information available.

Sodium PCA was not a developmental or reproductive toxicant in rats.3 Groups of 12 male and 12 female Wistar rats were dosed by gavage once daily with 0, 62.5, 250, or 1000 mg/kg bw/day sodium PCA in water. The females were dosed for 2 wks prior to mating until day 4 of lactation; the males were dosed for 14 days prior to mating and for 14 days during mating. No adverse effects on any measured parameters in the parents or offspring were observed. The no-observable adverse effect level (NOAEL) for maternal and reproductive toxicity was listed as 1000 mg/kg bw/day. Ocular Irritation No ocular irritation was observed when 50% aq. sodium PCA were instilled into the conjunctival sac of the eye of rabbits.1 The ocular irritation potential of sodium PCA was evaluated in vitro using a chicken eye test method for identifying ocular corrosives and severe irritants; sodium PCA was classified as non-irritating.3 Sodium PCA also was found to be non-irritating to rabbit eyes in an in vivo study. Sodium PCA, 0.1 g neat, was instilled into the conjunctival sac of one eye of three New Zealand White rabbits, and the eyes were rinsed after 1 h. Slight conjunctival redness and discharge were observed in all three animals 1 h after administration; all reactions were reversed within 48 h, and sodium PCA was considered non-irritating.

General safety info about Calcium Pca from CIR

The Cosmetic Ingredient Review (CIR) Expert Panel reassessed the safety of PCA (2-pyrrolidone-5- carboxylic acid) and its salts; the Panel added three previously un-reviewed salts of PCA to this safety assessment. PCA and its salts are reported to function in cosmetics as skin conditioning agents – humectants. The Panel reviewed the data from the 1999 report of PCA and sodium PCA, as well as additional data included in this report, to determine the safety of these ingredients. The Panel concluded that PCA and its salts are safe as used in cosmetic formulations; additionally these ingredients should not be used in cosmetic products in which N-nitroso compounds can be formed.

Use this, not that!

Products where you might find Calcium Pca

AGENT NATEUR Holi(c); Kiehl’s Since 1851 Powerful Wrinkle Reducing Eye Cream;Kiehl’s Since 1851 Powerful Wrinkle Reducing Cream Sunscreen Broad Spectrum SPF 30;Kiehl’s Since 1851 Powerful Wrinkle Reducing Cream