Caprylyl Glycol

The Basics On Caprylyl Glycol

What is Caprylyl Glycol?

An alcohol derived from caprylic acid, which is found naturally found in palm and coconut oils but may be synthetic.

What are other names for Caprylyl Glycol?

1,2-DIHYDROXYOCTANE, 1,2-OCTANEDIOL, 1,2-OCTYLENE GLYCOL, 1,2OCTANEDIOL, CAPRYL GLYCOL, CAPRYLYL GLYCOL, and OCTANE-1,2-DIOL

What is Caprylyl Glycol used for?

Caprylyl glycol is a humectant, meaning it’s a substance that helps the skin retain water. “Humectants are used in the formulation of lotions, moisturizers, and cleansers in order to help lock in moisture,” explains Solomon. “This is important to prevent dry skin while also slowing down signs of aging.

How Caprylyl Glycol is classified

Plant Extracts, Preservatives

Recommendations for using Caprylyl Glycol during pregnancy and breastfeeding

Limited data suggests no known risk

 

Caprylyl Glycol During Pregnancy

What we know about using Caprylyl Glycol while pregnant or breastfeeding

Limited information available.

An NOAEL of 1,000 mg/kg for reproductive/developmental toxicity has been reported for 1,2-butanediol in rats dosed orally. In a prenatal reproductive toxicity study involving rats dosed orally with 1,2-hexanediol , an NOEL of 300 mg/kg was reported. In other studies, no significant adverse reproductive or developmental effects in oral studies when evaluated in mice at concentrations of ≤5.0% PG, rats at doses of ≤1600 mg/kg PG, rabbits at doses of ≤1230 mg/kg PG, or hamsters at doses of ≤1550 mg/kg PG. Embryonic development was reduced or inhibited completely in cultures of mouse zygotes exposed to 3.0 or 6.0 M PG, respectively. A study examining induction of cytogenetic aberrations in mice reported an increase in the frequency of premature centromere separation (PCS) with 1300-5200 mg/kg PG. In zygotes from PG-dosed mice, hyperploidy was increased. 1,2-Butanediol The test procedure for the combined repeated dose and reproductive/developmental toxicity study (Crj-CD(SD) rats) and results relating to oral toxicity are included in the Short-Term Oral Toxicity section earlier in the report text. All of the animals were killed on day 4 of lactation. Neither effects on reproduction (copulation, implantation, pregnancy, parturition, or lactation) nor developmental toxicity effects on offspring were observed. The NOAEL was 1,000 mg/kg for parental animals and the F1 generation.31 The estimated dose of low concern (EDCL) for this study was calculated as 10 mg/kg/day.7 1,2-Hexanediol 1,2-hexanediol was administered orally (by gavage) to rats at doses of 30, 100, and 300 mg/kg body weight in a prenatal developmental toxicity study (OECD 414 protocol). An NOEL of 300 mg/kg was reported.43 Propylene Glycol A continuous breeding reproduction study was conducted using COBS Crl:CD-1 (ICR)BR outbred Swiss albino mice (6 weeks old).46 The continuous breeding phase of the study (task II) was begun after the dose-setting study (task I) and involved 3 experimental groups (40 mice per group) and a control group of 80 mice. Experimental and control groups contained an equal number of male and female mice. The 3 experimental groups were given the following doses (in feed or water), respectively, during a 7-day pre-mating period: 1.0% propylene glycol (daily dose of 1.82 g/kg), 2.5% propylene glycol (daily dose of 4.80 g/kg), and 5.0% propylene glycol (daily dose of 10.10 g/kg). Task 3 (crossover mating trial, not CIR Expert Panel Page 55 14 performed) was to have been performed only if significant effects on fertility were observed, to determine whether F0 males or females were more sensitive to these effects. To perform an offspring assessment of reproductive function (task 4) following exposure to propylene glycol, the dam (from phase II) was dosed through weaning and F1 mice were dosed until mating occurred at 74 ± 10 days of age. Mating pairs consisted of male and female offspring from the same treatment group (20/group/sex); F2 litters were examined. In the continuous breeding phase (task II), there were no significant changes (p < 0.05) in mean live pup weight per litter between the control group and any of the treatment groups. In task IV (offspring assessment of reproductive function), only the highdose group (5% propylene glycol) was involved. There were no significant differences (p < 0.05) between control and experimental groups with respect to the following observations in task IV: mating index, fertility index, mean number of live pups per litter, proportion of pups born alive, and sex of pups born alive.46 From the Amended Final Report on Propylene Glycol, Tripropylene Glycol, and Polypropylene Glycols2 The reproductive and developmental effects of PG were evaluated using mice, rats, rabbits, and hamsters.47 Groups of 25 or 28 female albino CD-1 outbred mice were mated and 22, 22, 22, 20, and 23 gravid mice were dosed by oral intubation with 0.0, 16.0, 74.3, 345.0, and 1600.0 mg/kg aq. PG on days 6-15 of gestation. Groups of 25-28 female albino Wistar rats were mated and 22, 23, 22, 20, and 24 were dosed as above, respectively. Positive control groups of 23 mice and 21 rats were given 150.0 or 250.0 mg/kg aspirin, respectively. Body weights were recorded at various intervals and general observations were made daily. Caesarian sections were performed on days 17 and 20 for all mice and rats, respectively. All fetuses were examined macroscopically for visceral or skeletal defects. Administration of PG did not affect maternal or fetal survival in mice or rats, and there were no statistically significant differences in fetal anomalies between test and negative control groups in mice or rats. Groups of 11, 11, 12, 14, and 13 gravid female Dutch-belted rabbits were dosed by oral intubation with 0, 12.3, 57.1, 267.0, or 1230.0 mg/kg aq. PG on days 6-18 of gestation, respectively. A positive control group of 10 gravid rabbits was given 2.5 mg/kg 6-aminonicotinamide. Body weights were recorded at various intervals and general observations were made daily. Caesarian sections were performed on day 29. All fetuses were examined macroscopically and kept for 24 h to evaluate survival. The pups were then examined viscerally and for skeletal defects. Administration of PG did not affect maternal or fetal survival, and there were no statistically significant differences in fetal anomalies between test and negative control group. Groups of 24-27 female golden hamsters were mated and 21, 24, 25, 22, and 22 gravid hamsters were dosed by oral intubation with 0.0, 15.5, 72.0, 334.5, and 1550.0 mg/kg aq. PG on days 6-10 of gestation, respectively. Positive controls were given 250.0 mg/kg aspirin. Body weights were recorded at various intervals and general observations were made daily. Caesarian sections were performed on day 14. All fetuses were examined macroscopically and for visceral or skeletal defects. Administration of PG did not affect maternal or fetal survival, and there were no statistically significant differences in fetal anomalies between test and negative control groups.47 From the Amended Final Report on Propylene Glycol, Tripropylene Glycol, and Polypropylene Glycols2 PG was used as a vehicle in a reproductive and behavioral development study. 48 It was administered to 15 gravid SpragueDawley rats orally by gavage on days 7-18 of gestation at a volume of 2 ml/kg. PG did not have any effects on reproductive or behavioral development parameters. From the Amended Final Report on Propylene Glycol, Tripropylene Glycol, and Polypropylene Glycols2 Embryonic development was reduced or inhibited completely in cultures of mouse zygotes exposed to 3.0 or 6.0 M PG, respectively. From the Final Report on Propylene Glycol and Polypropylene Glycols1 Female ICR mice were used to determine whether PG induced cytogenetic aberrations in mouse metaphase II (MII) oocytes that predispose zygotes to aneuploidy.30 Groups of mice were first given an i.p. injection of 7.5 IU hCG to augment follicular CIR Expert Panel Page 56 15 maturation followed 48 h later with 5 IU hCG to induce ovulation. After 3 h, mice were dosed i.p. with 1300, 2600, or 5200 mg/kg PG in distilled water. A control group was given distilled water only. For the MII portion of the study, ovulated oocytes were collected from 20 test animals/group and 30 control animals and processed for cytogenetic analysis 16 h after administration of PG. The number of oocytes collected from test animals was non-statistically significantly increased compared to controls. A statistically significant change in hyperploidy, hypoploidy, or single chromatids was not observed. An increase in the frequency of PCS at each dose was statistically significant, and the incidence of premature anaphase was significantly greater in the 5200 mg/kg dose group as compared to controls. Neither metaphase I nor diploid oocytes were found. For the zygote portion of the study, the female mice were paired with undosed males immediately after being given hCG; the females were dosed i.p. with 1300, 2600, or 5200 mg/kg PG 3 h after hCG administration. The males were removed 16 h after dosing with PG. Mated females were given colchine 22 h after dosing with PG; zygotes were collected 18 h later. There were 30, 40, 49, and 66 mice in the control, 1300, 2600, and 5200 mg/kg groups, respectively. The increase in hyperploidy was statistically significant in all test groups compared to controls. A statistically significant change was not seen for polyploidy or hypoploidy, and zygotes containing PCS, premature anaphase, or single chromatids were not found. The authors noted that there was not a statistically significant difference in the proportion of zygotes collected for each group compared to oocytes. However, the number of zygotes analyzed compared to the number placed on slides was significantly decreased in the test groups; a relatively large portion of these zygotes had clumped chromosomes. 30 From the Amended Final Report on Propylene Glycol, Tripropylene Glycol, and Polypropylene Glycols2

General safety info about Caprylyl Glycol from CIR

No report found.

Use this, not that!

Products where you might find Caprylyl Glycol

REN Clean Skincare Glycol Lactic Radiance Renewal Mask; Sol de Janeiro Brazilian Bum Bum Cream; Sol de Janeiro Mini Brazilian Bum Bum Cream