Cassia Angustifolia Seed Polysaccharide

The Basics On Cassia Angustifolia Seed Polysaccharide

What is Cassia Angustifolia Seed Polysaccharide?

The polysaccharide portion derived from the seed of the Cassia angustifolium plant.

What are other names for Cassia Angustifolia Seed Polysaccharide?

ALEXANDRIAN SENNA SEED POLYSACCHARIDE, CASSIA ANGUSTIFOLIA (ALEXANDRIAN SENNA) SEED POLYSACCHARIDE, and CASSIA ANGUSTIFOLIA SEED POLYSACCHARIDE

What is Cassia Angustifolia Seed Polysaccharide used for?

Cassia Angustifolia (Senna) is a native plant from Yemen, Somal, a and Arabia. It is now cultivated in other parts of the world and has a variety of medicinal uses as well as uses in other traditional systems of medicine. The plant is mainly valued for its cathartic properties and is especially useful in habitual constipation. The Cassia Angustifolia (Senna) plant extract possesses remarkable antimicrobial activity and could act an antifungal agent.

How Cassia Angustifolia Seed Polysaccharide is classified

Emollients, Plant Extracts

Recommendations for using Cassia Angustifolia Seed Polysaccharide during pregnancy and breastfeeding

Limited data suggests no known risk

 

Cassia Angustifolia Seed Polysaccharide During Pregnancy

What we know about using Cassia Angustifolia Seed Polysaccharide while pregnant or breastfeeding

Limited information available.

Carrageenan, Calcium Carrageenan, 15 And Sodium Carrageenan Long-term multigeneration effects of the dietary intake of calcium carrageenan were measured in a three-generation reproduction and teratology study using Osborne-Mendel rats.95 Dietary levels of 0.5%, 1.0%, 2.5% or 5.0% were ingested throughout the study. Carrageenan ingestion caused dose-related and significant decreases in the weights of offspring at weaning, but no effects on the following parameters were detected: average litter size, average number of liveborn animals, viability or survival of offspring.The teratogenicity/fetotoxicity of calciumκ,λ-carrageenan, sodiumκ,λ-carrageenan, and ι-carrageenanwas studied using Syrian hamsters (Mesocricetus auratus).96 Doses of 10, 40, 100 or 200 mg/kg/day were given by oralintubation on days 6 through 10 of gestation. No dose-related teratogenic or fetotoxic effects occurred after dosing with either of the 3 test substances.CroscarmelloseIn a developmental toxicity study on croscarmellose sodium, groups of pregnant Sprague-Dawley rats (25/group) were fed 0 ppm (control), 10,000 ppm, or 50,000 ppm Ac-Di-Sol (croscarmellose sodium) in the diet on gestation days 6 to 15.78 No evidence of maternal, fetal, or embryotoxicity was noted. External malformations were not observed in this study, and there were no statistically significant findings that were considered treatment-related. The no-observed-adverse-effect level (NOAEL) for croscarmellose in both studies exceeded 50,000 ppm in the diet, which represents doses of 3922 and 4712 mg/kg/day for males and females, respectively.CyclodextrinThe embryotoxicity/teratogenicity of γ-cyclodextrin was examined using Wistar Crl:(WI)WU BR rats.97γ-Cyclodextrin was fed at dietary concentrations of 0, 1.5, 5, 10, and 20% to groups of 25 pregnant female rats from day 0 to 21 of gestation. A comparison group received a diet containing 20% lactose. The rats were killed on day 21 and examined for standard parameters of reproductive performance. The fetuses were examined for signs of toxic and teratogenic effects. Generally, γ-cyclodextrin was well-tolerated and no deaths occurred in any group. Weight gain and food consumption were similar in all groups during gestation, except for a slightly reduced food intake in the 20%γ-cyclodextrin group from day 0 to 16. Reproductive performance was not affected by treatment with γ-cyclodextrin. Examination of the fetuses for external, visceral, and skeletal alterations did not reveal any fetotoxic, embryotoxic, or teratogenic effects ofγ-cyclodextrin. It was concluded that no adverse effects were observed at γ-cyclodextrin concentrations up to approximately 20% in the diet (approximately 11 g/kg body weight/day).In a similar study, the embryotoxicity/teratogenicity of α-cyclodextrin was examined in Wistar Crl:(WI)WU BR rats. α-Cyclodextrin was fed at dietary concentrations of 0, 1.5, 5, 10, or 20% to groups of 25 pregnant female rats from day 0 to 21 of gestation.98 An additional group received a diet containing 20% lactose. The rats were killed on day 21 and examined for standard parameters of maternal reproductive performance. The fetuses were examined for skeletal and visceral abnormalities, body weight and crown rump length. Generally, α-cyclodextrin was well-tolerated and no deaths occurred in any group. Weight gain and food consumption were similar in all groups during gestation, except for a slightly, yet significantly, increased food intake in the 20% α-cyclodextrin group on days 6 to 16 (p < 0.05) and 16 to 21 (p < 0.001). Maternal reproductive performance was not affected by α-cyclodextrin treatment. Examination of the fetuses for external, visceral, and skeletal changes did not reveal any fetotoxic, embryotoxic, or teratogenic effects ofα-cyclodextrin. It was concluded that no adverse effects were observed at α-cyclodextrin concentrations up to 20% in the diet, the highest concentration tested, which corresponded to approximately 13 g/kg body weight/day.In a standard embryotoxicity/teratogenicity study, γ-cyclodextrin was administered to groups of 16 artificially inseminated New Zealand White rabbits at dietary concentrations of 0, 5, 10, or 20%.99 A comparison group received a diet containing 20% lactose. Treatment started on day 0 of gestation and ended on day 29, when the animals were killed. Except for the occurrence of transient diarrhea in 2 and 3 rabbits of the 10% and 20%γ-cyclodextrin groups, respectively, in the first few days, the treatment was well-tolerated. Reduced food intake in the 20% γ-cyclodextrin group during the first week of treatment resulted in reduced weight gain during this period. However, after week 1, there were no differences in weight gain among the groups and, at termination of the study, body weights were similar in all groups. Even at the highest dose, which corresponded to an intake of 5–7 g/kg body weight/day, no signs of maternal toxicity were observed. Reproductive performance was not affected by the treatment. Uterine weight, placental weight, fetal weight, number of fetuses, sex ratio, number of implantation sites, resorptions, and corpora lutea did not differ among the groups. Visceral and skeletal examinations of the fetuses did not reveal any malformations, anomalies, or variations that could be attributed to treatment. 16 It was concluded that dietary γ-cyclodextrin was well-tolerated by pregnant rabbits, had no adverse effect on reproductive performance, and was not embryotoxic, fetotoxic, or teratogenic at dietary concentrations up to 20%. α-Cyclodextrin was also administered to groups of 16 artificially inseminated New Zealand White rabbits at dietary concentrations of 0, 5, 10, or 20%.100 An additional group received a diet containing 20% lactose. Treatment started on day 0 of gestation and ended on day 29, when the animals were killed. Except for the occurrence of transient diarrhea in one rabbit of the 20% α-cyclodextrin group for a few days, the treatment was well-tolerated. Reduced food intake in the 20% α-cyclodextrin group during the first week of treatment resulted in reduced weight gain from day 0 to 12 of the study.However, when compared to controls, the difference was not significant. At study termination, body weights were similar in all groups. Even at the highest dose level, which corresponded to an intake of 5.9–7.5 g/kg body weight/day, no signs of maternal toxicity were observed. Maternal reproductive performance was not affected by treatment. Uterine weight, placental weight, fetal weight, number of fetuses, sex ratio, number of implantation sites, resorptions, and corpora lutea did not differ among the groups. Visceral and skeletal examinations of the fetuses did not reveal any malformations, anomalies, or variations that could be attributed to treatment. It was concluded that dietary α-cyclodextrin was generally well-tolerated by pregnant rabbits, had no adverse effect on maternal reproductive performance, and was not embryotoxic, fetotoxic, or teratogenic at dietary concentrations of up to 20%, the highest dose level tested.

General safety info about Cassia Angustifolia Seed Polysaccharide from CIR

No report found.

Use this, not that!

Products where you might find Cassia Angustifolia Seed Polysaccharide

Naturopathica Rosehip Seed Regenerating Facial; Christophe Robin Regenerating Mask with Rare Prickly; Briogeo Curl Charisma Chia & Flax Seed Oil; Eminence Organic Skin Care; N/A