Cyamopsis Tetragonoloba

The Basics On Cyamopsis Tetragonoloba

What is Cyamopsis Tetragonoloba?

What are other names for Cyamopsis Tetragonoloba?

GUAR GUM, CYAMOPSIS TETRAGONOLOBA (GUAR) GUM, CYAMOPSIS TETRAGONOLOBA GUM, CYANOPSIS TETRAGONOLOBA GUM, GUAR (CYAMOPSIS TETRAGONOLOBA) GUM, GUAR GUM, GUAR GUM (CYAMOPSIS TETRAGONOLOBUS (L.)), GUAR GUM; GUAR GUM (CYAMOPSIS TETRAGONOLOBUS); SOLVENT PURIFIED GUAR GUM, GUM, CYANOPSIS TETRAGONOLOBA, and GUM, GUAR

What is Cyamopsis Tetragonoloba used for?

How Cyamopsis Tetragonoloba is classified

Plant Extracts, Texture Enhancer

Recommendations for using Cyamopsis Tetragonoloba during pregnancy and breastfeeding

Limited data suggests no known risk

 

Cyamopsis Tetragonoloba During Pregnancy

What we know about using Cyamopsis Tetragonoloba while pregnant or breastfeeding

Limited information available.

Groups of male and female Osborne-Mendel rats (4 weeks old; 34 to 40/group) were fed cyamopsis tetragonoloba (guar) gum in the diet at concentrations of 0, 1, 3, 4, 7.5, or 15% 13 weeks prior to mating, during mating, and throughout gestation.88 Groups of female rats consumed 0, 0.7, 1.4, 2.7, 5.2, or 11.8 g/kg body weight/day, respectively, during gestation. The animals were killed on gestation day 20. None of the females died during the study. The ingestion of cyamopsis tetragonoloba (guar) gum prior to mating had no effect on fertility. No effects on the number of corpora lutea or implantations were observed in the 1% to 7.5% cyamopsis tetragonoloba (guar) gum dietary groups. When compared to the control group, slightly fewer corpora lutea and implantations were observed in the 15% dietary group; however, there was no effect on implantation efficiency. A slight reduction (not statistically significant) in the number of viable fetuses per litter was also noted in the 15% dietary group. Because the number of resorptions was not affected in this group, this reduction appeared to have been an effect of the decreased number of corpora lutea. It was concluded that cyamopsis tetragonoloba (guar) gum in the diet had no effect on fetal development or sex distribution and was not teratogenic. In another teratogenicity study on cyamopsis tetragonoloba (guar) gum, groups of virgin adult female albino CD-1 outbred mice (ages not stated) were mated with young adult males, and observation of the vaginal sperm plug was considered day 0 of gestation.89 The following groups of mated female mice received daily oral doses of cyamopsis tetragonoloba (guar) gum (in corn oil; dose volume = 1 ml/kg body weight) on days 6 through 15 of gestation: 22 mice (8 mg/kg/day), 26 mice (37 mg/kg/day), 25 mice (170 mg/kg/day), and 29 mice (800 mg/kg/day). A sham-treated control group was also included and aspirin served as the positive control. Doses up to 170 mg/kg/day had no clearly discernible effect on nidation or on maternal or fetal survival. Additionally, the number of abnormalities observed in either skeletal or soft tissues of test groups did not differ from the number that occurred spontaneously in sham-treated controls. In the 800 mg/kg/day dose group, a significant number of maternal deaths (6 of 29) was reported. Surviving dams appeared completely normal and the same was true of fetuses. No effects on the rate of nidation or survival of live pups in utero was noted. It was concluded that, under the conditions of this test, cyamopsis tetragonoloba (guar) gum was not teratogenic in mice. The teratogenicity of cyamopsis tetragonoloba (guar) gum in rats and hamsters was also evaluated in this study. Except for the administration of different doses and a shorter dosing period for hamsters, the test procedure was the same. Results are summarized below. Four groups of 24 mated female rats (ages not stated) received cyamopsis tetragonoloba (guar) gum (in corn oil) at daily oral doses of 9, 42, 200, and 900 mg/kg/day, respectively. Doses up to 900 mg/kg/day had no clearly discernible effect on nidation or on maternal or fetal survival. The number of abnormalities observed in either skeletal or soft tissues of test groups did not differ from the number that occurred spontaneously in sham-treated controls. The following groups of mated female hamsters (ages not stated) received daily oral doses of cyamopsis tetragonoloba (guar) gum (in corn oil): 22 hamsters (6 mg/kg/day), 22 hamsters (28 mg/kg/day), 25 hamsters (130 mg/kg/day), and 20 hamsters (600 mg/kg/day) on days 6 through 10 of gestation. Doses up to 600 mg/kg/day had no clearly discernible effect on nidation or on maternal or fetal 16 survival. Furthermore, the number of abnormalities observed in either skeletal or soft tissues of test groups did not differ from the number that occurred spontaneously in sham-treated controls.89

General safety info about Cyamopsis Tetragonoloba from CIR

The galactomannans are legume polysaccharides that function mostly as hair/skin conditioning agents and viscosity increasing agents in cosmetic products. Their substantial molecular sizes suggest that skin penetration of these ingredients would be unlikely. The CIR Expert Panel concluded that the galactomannans are safe in the present practices of use and concentration described in this safety assessment.

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