Dicaprylyl Carbonate

The Basics On Dicaprylyl Carbonate

What is Dicaprylyl Carbonate?

An emollient ingredient that may be derived from synthetic or animal sources.

What are other names for Dicaprylyl Carbonate?

CARBONIC ACID, DICAPRYLYL ESTER, CARBONIC ACID, DIOCTYL ESTER, DICAPRYLYL CARBONATE, and DICAPRYLYL ESTER CARBONIC ACID

What is Dicaprylyl Carbonate used for?

Dicaprylyl carbonate is desirable for products such as facial moisturizers because it spreads easily and leaves a velvety feel on skin without seeming greasy or slick. It also helps enhance the absorption of other ingredients in a cosmetic formula.

How Dicaprylyl Carbonate is classified

Emollients

Recommendations for using Dicaprylyl Carbonate during pregnancy and breastfeeding

Limited data suggests no known risk

 

Dicaprylyl Carbonate During Pregnancy

What we know about using Dicaprylyl Carbonate while pregnant or breastfeeding

Limited information available.

Oral Diethylhexyl Carbonate Data on the embryotoxicity/teratogenicity of 2-ethylhexanol have been proposed for use in evaluating this endpoint in the absence of data on Diethylhexyl Carbonate, and are included in an ECHA registration dossier on Diethylhexyl Carbonate.39 Groups of 10 pregnant female Wistar rats were dosed orally with 2-ethylhexanol (in water containing 0.005% PEG-35 castor oil) at dose rates of 130, 650, and 1300 mg/kg body weight/day on gestation days 6 through 15 of gestation. The test protocol was conducted in accordance with OECD Guideline 414. The negative control group was dosed with vehicle only. The animals were killed on gestation day 20, and post-mortem examinations performed. Significant maternal toxicity was observed in the 1300 mg/kg/day group, and the following results were reported: discoloration of the liver and lung, pronounced clinical symptoms (nasal discharge, salivation, and CNS depression), reduced, food consumption, and body weight loss. Six of the 10 pregnant females dosed with 1300 mg/kg/day died. Slight maternal toxicity was noted at a dose of 650 mg/kg/day, but not at 130 mg/kg/day. The following embryotoxic/teratogenic effects were reported after dosing with 1300 mg/kg/day: increased early resorptions, high postimplantation loss, markedly reduced fetal body weights, fetuses with a dilated renal pelvis and/or hydroureter, and increased incidences of skeletal malformations, variations, and retardations. In the 650 mg/kg/day dose group, slightly reduced mean fetal body weights and an increased frequency of fetuses with skeletal variations and retardations were observed. There were no adverse test substance-related effects on the dams or fetuses in the 130 mg/kg/day dose group. Distributed for Comment Only — Do Not Cite or Quote After considering that maternal toxicity was most severe at 1300 mg/kg/day, marginal at 650 mg/kg/day, and nonexistent at 130 mg/kg/day, the NOAEL for this endpoint was determined to be 130 mg/kg/day. Because dose-dependent signs of embryotoxicity/fetotoxicity were observed in dams with signs of maternal toxicity at doses of 650 and 1300 mg/kg/day, the NOAEL was determined to be 130 mg/kg/day for this endpoint. The NOAEL for teratogenicity was determined to be 130 mg/kg/day because teratogenicity was observed only in fetuses from the highest dose group. Inhalation Dimethyl Carbonate In a reproductive and developmental toxicity study, groups of 96 mated female CD-1 mice were exposed (6 h/day) to 300 ppm, 1000 ppm, or 3000 ppm Dimethyl Carbonate during gestation days 6 through 15 (organogenesis period).27,35 Untreated mice served as controls. The females were killed on gestation day 18, after which fetuses from the first 30 to 32 pregnant dams were examined for external, visceral, and skeletal alterations. Exposure to 3000 ppm caused a significant reduction (p < 0.01) in maternal body weight and body weight gain. Food consumption was also significantly reduced after exposure to Dimethyl Carbonate at concentrations of 1000 ppm and 3000 ppm, indicating an adverse effect on the dams. Exposure to 3000 ppm also caused post-implantation loss, as evidenced by increased resorptions, increased number of stunted fetuses (< 1 g body weight), and altered sex ratio (fewer males surviving). A significant reduction (p < 0.01) in fetal body weight was also noted after exposure to 3000 ppm, indicating a gross adverse effect on the fetus. The following fetal malformations were statistically significantly elevated after exposure to 3000 ppm: cleft palate (p < 0.01), microtia [small ear] (p < 0.05), low set ears (p < 0.05), imperforate anus (p < 0.05), and ectrodactyly (p < 0.05). An increase in multiple malformations of bones of the skull and in fused vertebral arches was also observed at this concentration. Increased skeletal variations at 3000 ppm included misshapen sternebrae (breastbones), rudimentary cervical ribs, and well-formed cervical or lumbar ribs. The effects on reproduction and fetal development, especially increased incidences of fetal malformations, were observed at a dose level at which general toxicity, such as decreased body weight gain in parental animals, was manifested. The NOAEL for maternal and developmental toxicity was 1000 ppm.27,35

General safety info about Dicaprylyl Carbonate from CIR

The Cosmetic Ingredient Review (CIR) Expert Panel reviewed the safety of 6 dialkyl carbonates, which function mostly as skin conditioning agents in cosmetic products. The Panel reviewed relevant data relating to the safety of these ingredients, and concluded that the dialkyl carbonates are safe in the present practices of use and concentration in cosmetics when formulated to be non-irritating.

Use this, not that!

Products where you might find Dicaprylyl Carbonate

Erno Laszlo The Famous Pink Mask; Omorovicza Thermal Cleansing Balm; Omorovicza Hungary’s Best Beauty Secrets