The Basics On Diisostearyl Malate
What is Diisostearyl Malate?
Diisostearyl malate is an ester that functions as an emollient.
What are other names for Diisostearyl Malate?
BIS(16-METHYLHEPTADECYL)ESTER BUTANEDIOIC ACID, HYDROXY-, BIS(16-METHYLHEPTADECYL)ESTER HYDROXYBUTANEDIOIC ACID, BIS(16-METHYLHEPTADECYL)HYDROXYBUTANEDIOATE, BUTANEDIOIC ACID, HYDROXY-, BIS(16-METHYLHEPTADECYL)ESTER, DIISOSTEARYL MALATE, DIISOSTEARYL MALEATE, HYDROXY- BIS(16-METHYLHEPTADECYL)ESTER BUTANEDIOIC ACID, and HYDROXYBUTANEDIOIC ACID, BIS(16-METHYLHEPTADECYL)ESTER
What is Diisostearyl Malate used for?
Diisostearyl malate is an ester that functions as an emollient in cosmetics. It is created from malic acid and isostearyl alcohol. This ingredient is most commonly used in lipsticks and has been deemed safe for use by the Cosmetic Ingredient Review board.
How Diisostearyl Malate is classified
Emollients
Recommendations for using Diisostearyl Malate during pregnancy and breastfeeding
Limited data suggests no known risk
Diisostearyl Malate During Pregnancy
What we know about using Diisostearyl Malate while pregnant or breastfeeding
Limited information available.
No reproductive or developmental studies were discovered for the ingredients in this safety assessment, however, data from developmental toxicity studies were available for malic acid and dibutyl malate. Malic Acid Malic acid did not cause developmental toxicity in albino CD-I outbred mice (n = 25) up of to 266 mg kg (days 6-15 of gestation), rats (n = 25-29) of up to 350 mg/kg (for 10 days during gestation), or Dutch-belted rabbits (n 15-23) of up to 300 mg kg (days 6-18 of gestation).34-36 In a multigenerational oral study of malic acid, there were no reproductive or developmental effects to albino rats for up to 10 000 ppm of feed for the PI, P2, F l, and F2 generations.37 Malic acid (10.00 mg egg in water) was injected into the air sac or yolk of white leghorn chicken eggs (n 20) at the 0 or 96 hours of incubation. 38 There were no developmental effects observed when the chicks were examined after hatching. Dibutyl Malate In a repeated dose and reproductive toxicity/developmental toxicity screening assay for dibutyl malate (300 mg/kg), there were no adverse reproductive effects reported in rats.28
General safety info about Diisostearyl Malate from CIR
The Cosmetic Ingredient Review Expert Panel reviewed the safety of 6 dialkyl malate compounds used in cosmetics. These ingredients function mostly as skin-conditioning agents—emollients. The Panel reviewed relevant animal and human data related to the ingredients along with a previous safety assessment of malic acid. The similar structure, properties, functions, and uses of these ingredients enabled grouping them and using the available toxicological data to assess the safety of the entire group. The Panel concluded that these dialkyl maleate compounds are safe in the present practices of use and concentration as given in this safety assessment.
Use this, not that!
Products where you might find Diisostearyl Malate
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List of References
General sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/
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Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
