Diisostearyl Polyglyceryl-3 Dimer Dilinoleate

The Basics On Diisostearyl Polyglyceryl-3 Dimer Dilinoleate

What is Diisostearyl Polyglyceryl-3 Dimer Dilinoleate?

Diisostearyl polyglyceryl-3 dimer dilinoleate is an emollient blend of fatty acids often used in cosmetics to enhance coverage.

What are other names for Diisostearyl Polyglyceryl-3 Dimer Dilinoleate?

DIISOSTEAROYL POLYGLYCERYL-3 DIMER DILINOLEATE

What is Diisostearyl Polyglyceryl-3 Dimer Dilinoleate used for?

An emollient blend of fatty acids often used in cosmetics to enhance coverage, water-resistance, and wear time. Diisostearyl polyglyceryl-3 dimer dilinoleate also functions as an emulsifier. It may be animal-derived or synthetic.

How Diisostearyl Polyglyceryl-3 Dimer Dilinoleate is classified

Skin-Softening, Emollients, Emulsifiers

Recommendations for using Diisostearyl Polyglyceryl-3 Dimer Dilinoleate during pregnancy and breastfeeding

Limited data suggests no known risk

 

Diisostearyl Polyglyceryl-3 Dimer Dilinoleate During Pregnancy

What we know about using Diisostearyl Polyglyceryl-3 Dimer Dilinoleate while pregnant or breastfeeding

Limited information available.

Oral Polyglyceryl Esters – general A test group of 22 rats was fed a diet containing 1.5% polyglyceryl ester for 3 generations.32 A group of 28 rats was used as a control. The animals were kept for over 1 year without significant variation in fertility or reproductive performance. Gross and microscopic examination of the third generation revealed no consistent abnormality attributable to the test substance. No details were provided. Polyglyceryl-3 Diisostearate A combined repeated dose oral toxicity study with a reproduction/developmental toxicity screening test (OECD Guideline 422) was conducted in Wistar rats. 39 The animals were dosed once daily by gavage with 0, 100, 300, or 1000 mg/kg bw/day 1,2,3-propanetriol, homopolymer, diisooctadecanoate (n not defined; this substance is most likely Polyglyceryl-3 Diisostearate) in corn oil. Initially, the groups consisted of 12 males and 12 females. However, because a disturbance of the light/dark cycle was believed to cause a reduction in mating rate of the females of the first delivery, additional male and female rats were added in a second delivery for breeding to meet guideline requirements for the number of gravid females per group. All (1st and 2nd delivery) animals were subjected to the same conditions of the study, with the exception that the males of the second delivery were necropsied on day 24 after mating, not on day 16 of mating. Therefore, Polyglyceryl-3 Diisostearate was administered to male rats for up to 28 days (first delivery) and up to 41 days (second delivery) and to female rats for 14 days prior to mating, through the mating and gestation periods, and until the F1 generation reached day 4 post-partum. Because an impact caused by the light/dark cycle disturbance could not be excluded (i.e., a prolonged duration of gestation and an increased post-implantation loss at the high dose), the study was repeated with a third delivery with control and highdose groups under proper light conditions. The test article was administered to12 male rats/group for 33 days and to 12 female rats/group for 14 days prior to mating, through mating and gestation, and until day 4 post-partum. Five males and 5 females/group killed at the end of the study were selected for hematology and clinical chemistry examinations, and some additional organs were weighed. The NOEL and NOAEL for systemic effects were ‚â•300 mg/kg bw/day and ‚â•1000 mg/kg bw/day 1,2,3-propanetriol, homopolymer, diisooctadecanoate, respectively, in both males and females. No adverse effects on body weights and body weight gains, feed consumption, hematology, clinical chemistry, neurobehavior, or gross or microscopic lesions were observed. Statistically significant increases in absolute and relative liver and kidney weights in males and females of the 1000 mg/kg bw/day were not considered to be adverse effects because there was no evidence for an impairment of organ function by clinical pathology and histopathology. Additionally, increases in the absolute and relative heart weights in high-dose females were without histopathological correlation and considered to be incidental.

General safety info about Diisostearyl Polyglyceryl-3 Dimer Dilinoleate from CIR

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 274 polyglyceryl fatty acid esters. Each of the esters in this group is a polyether comprising 2 to 20 glyceryl residues, end-capped by esterification with simple carboxylic acids, such as fatty acids. Most of these ingredients are reported to function in cosmetics as skin-conditioning agents and/or surfactants. The Panel reviewed the available data and considered conclusions from relevant previous CIR reports, and determined that these ingredients are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating.

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Products where you might find Diisostearyl Polyglyceryl-3 Dimer Dilinoleate

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