Geraniol

The Basics On Geraniol

What is Geraniol?

A volatile fragrance ingredient extracted from geranium, geraniol is capable of causing sensitivity when applied to skin.

What are other names for Geraniol?

2,6-OCTADIEN-1-OL, 3,7-DIMETHYL-, 2,6-OCTADIEN-1-OL, 3,7-DIMETHYL-, (2E)-, 2,6OCTADIEN1OL, 3,7DIMETHYL, (E), 3,7-DIMETHYL- 2,6-OCTADIEN-1-OL, 3,7-DIMETHYL-2,6-OCTADIEN-1-OL, and GERANIOL

What is Geraniol used for?

How Geraniol is classified

Sensitizing, Fragrance: Synthetic and Fragrant Plant Extracts

Recommendations for using Geraniol during pregnancy and breastfeeding

Limited data suggests no known risk

 

Geraniol During Pregnancy

What we know about using Geraniol while pregnant or breastfeeding

Limited information available.

One female in the 1000 mg/kg/day group was found dead on Day 15 after mating, which was not attributed to treatment. During the first week of dosing, both males and females in the 1000 mg/kg/day group displayed transient signs of reduced activity and unsteady muscle reactions. Rats in the 1000 mg/kg/day group also displayed chin rubbing and salivation; salivation was also recorded in females in the 300 mg/kg/day group. Detailed physical and arena observations, sensory reactivity, grip strength or motor activity assessments of the animals did not detect any changes attributed to the test substance. Bodyweight gain of males in the 1000 mg/kg/day group was low during week 1. During gestation, bodyweight gain and feed consumption was low in females in the 1000 mg/kg/day group. Feed consumption remained low for females in the 1000 mg/kg/day group during lactation. Changes in hematology parameters were not considered to be adverse at the level observed. Biochemical analysis of blood plasma during week 2 of dosing showed high alanine amino transferase activity and bile acid concentration in females in the 1000 mg/kg/day group. Urea concentration was high and triglyceride concentration was low in males in the 1000 mg/kg/day group. The authors stated that these changes may be associated with the microscopic changes to the liver and kidneys. Male rats at all doses had hyaline droplet nephropathy in the kidneys, accompanied by tubular casts and/or tubular degeneration/regeneration. Hyaline droplet nephropathy in the kidneys of male rats is caused by accumulation of α 2 microglobulin (produced by the liver) in the proximal tubules, which leads to subsequent damage and regeneration of the tubular epithelium. The authors note that this has been reported with a number of organic chemicals, but it appears to be a male, rat-specific toxicological response that has no counterpart in humans. The absence of any tubular injury in the test article treated females supports the conclusion that the tubular degeneration is secondary to the male specific hyaline droplet accumulation. All dose levels resulted in centrilobular hepatocytic hypertrophy in the livers of males and an increase in glycogenic vacuolation in the livers of females. Minimal centrilobular hepatocytic hypertrophy of the male livers associated with liver weight increase was considered an adaptive change likely associated with microsomal enzyme induction. A slight increase in the incidence and severity of glycogenic vacuolation in the livers of treated female compared with controls may be partially responsible for the liver weight increase. Although centrilobular hepatocytic hypertrophy was not recorded in the females, a minimal diffuse hypertrophy could account for the liver weight increase in this sex, but would be difficult to detect histologically. The liver changes were not considered to be adverse. There were no microscopic correlates for the decrease in spleen weight and the increase in adrenal weight of the high-dose females. The no-observed-adverse-effect-level (NOAEL) for males was 1000 mg/kg based on hyaline droplet nephropathy at all dose levels; however this response is considered to be rat specific and to have no counterpart in man. The NOAEL for females was 300 mg/kg based on effects on bodyweight, feed consumption. 4 Male Wistar rats (n = 8) were administered Eucalyptus Globulus Leaf Extract (130 mg/dry leaves/kg) in drinking water for 42 days.45 A control group was administered water. The extract (Table 3) was mixed with water (1 g/L) and provided to the rats as their drinking water; the rats consumed approximately 130 mg/dry Eucalyptus Globulus Leaf Extract/day. There were no differences in creatinine, urea, protein, or uric acid in the blood of the two groups. In measurements of oxidative damage and antioxidant activities in the kidneys, there were no differences in levels of peroxidation and activities, SOD, glutathione peroxidase (GPX), and catalase (CAT). There were no differences observed between the two groups when the kidneys were examined microscopicall

General safety info about Geraniol from CIR

No report found.

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Products where you might find Geraniol

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