The Basics On Glutamic Acid
What is Glutamic Acid?
Glutamic acid is an amino acid that helps aid skin hydration.
What are other names for Glutamic Acid?
1-AMINOPENTANEDIOIC ACID, 1-AMINOPROPANE-1,3-DICARBOXYLIC ACID, 2-AMINOGLUTARIC ACID, GLUTAMIC ACID, GLUTAMINIC ACID, L-GLUTAMIC ACID, and LGLUTAMIC ACID
What is Glutamic Acid used for?
Glutathione is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine). Glutathione is an antioxidant present in almost every cell in the body, playing a role in the detoxification of drugs and xenobiotics1. Glutathione is better known as an orally taken compound with some studies on the topical application for skincare. Glutathione acts as an antioxidant, a free radical scavenger, and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes2. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes2.
How Glutamic Acid is classified
Hydration
Recommendations for using Glutamic Acid during pregnancy and breastfeeding
Limited data suggests no known risk
Glutamic Acid During Pregnancy
What we know about using Glutamic Acid while pregnant or breastfeeding
Limited information available.
N/A
General safety info about Glutamic Acid from CIR
The Cosmetic Ingredient Review Expert Panel reviewed the safety of α-amino acids, which function primarily as hair and skin conditioning agents in cosmetic products. The safety of α-amino acids as direct food additives has been well established based on extensive research through acute and chronic dietary exposures. The Panel focused its review on dermal irritation and sensitization data relevant to the use of these ingredients in topical cosmetics. The Panel concluded that α-amino acids were safe as cosmetic ingredients in the practices of use and concentration of this safety assessment
Use this, not that!
Products where you might find Glutamic Acid
Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum, Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum, Perricone MD Essential Fx Acyl-Glutathione Smoothing & Brightening Under-Eye Cream
List of References
General sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/
1. Villarama C, Maibach H. Glutathione as a depigmenting agent: an overview. Int J Cosmet Sci. 2005;27(3):147-153. [PubMed] 2. Glutathione ‚Äì Pharmacology and Biochemistry. PubChem- Open Chemistry Database. pubchem.ncbi.nlm.nih.gov/compound/glutathione#section=Pharmacology-and-Biochemistry. Published 2018. Accessed September 2018. 3. Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 2017;10:147-153. [PubMed] 4. Watanabe F, Hashizume E, Chan G, Kamimura A. Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women. Clin Cosmet Investig Dermatol. 2014;7:267-274. [PubMed] 5. Sonthalia S, Jha A, Lallas A, Jain G, Jakhar D. Glutathione for skin lightening: a regnant myth or evidence-based verity? Dermatol Pract Concept. 2018;8(1):15-21. [PubMed] 6. Glutathione. EWG’s Skin Deep Cosmetic Database. https://www.ewg.org/skindeep/ingredient/702608/GLUTATHIONE/#.W7Cm0mgzZhE. Published 2018. Accessed October 2018.
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
