Glyceryl Isostearate

The Basics On Glyceryl Isostearate

What is Glyceryl Isostearate?

Used as an emollient and thickening agent in cosmetics.

What are other names for Glyceryl Isostearate?

GLYCERYL STEARATE SE, OCTADECANOIC ACID, ESTER WITH 1,2,3PROPANETRIOL, SELF-EMULSIFYING GLYCERYL MONOSTEARATE, and STEARINE

What is Glyceryl Isostearate used for?

Mixture of portions of glycerin and isostearic acid used as an emollient and thickening agent in cosmetics.

How Glyceryl Isostearate is classified

Thickeners/Emulsifiers, Emollients

Recommendations for using Glyceryl Isostearate during pregnancy and breastfeeding

Limited data suggests no known risk

 

Glyceryl Isostearate During Pregnancy

What we know about using Glyceryl Isostearate while pregnant or breastfeeding

Limited information available.

A reproduction/developmental toxicity screening test was conducted in male and female Sprague-Dawley rats for glyceryl oleate.23 Both males and females were dosed by gavage with 0, 100, 300, or 1000 mg/kg bw/day glyceryl oleate in corn oil once daily for 14 days prior to mating; the males were dosed for an additional 28 days, and dosing of the females continued until day 4 of lactation. There were 12 females in the control and 3 test groups, 7 males in the control and high dose groups, and 12 males in the low- and mid-dose groups. A satellite group of 5 males and 5 females were dosed for 42 days, with a 14- day post-dosing observation period. The NOAELs for systemic toxicity (males and females), fertility (males and females), and development (F1 generation) were 1000 mg/kg bw/day. No effects related to the administration of the test-article were observed in parental animals or offspring. For Read-Across In the 28-day oral toxicity study with 0, 100, 300 and 1000 mg/kg/day glycerides, C8-18 and C18-unsatd. mono- and di-, acetates in polyethylene glycol described in Table 10 (Repeated Dose Toxicity Studies), an additional 10 female Wistar Han rats were included in each group to assess reproduction and developmental toxicity. 22 After a minimum of 14 days of dosing, females of the reproduction study group were cohabitated with a male from the same treatment group. The test females were dosed for a total of 41-49 days, i.e. during those 2 weeks prior to mating, during mating, during post-coitum, and during at least 4 days of lactation. No treatment-related effects were observed, and the NOAEL for parental fertility was 1000 mg/kg bw/day. Glyceryl Hydrogenated Rosinate and Glyceryl Rosinate Following the administration of hexane extracts of Pinus ponderosa needles to mice by stomach tube, increased embryonic resorptions were observed.7 Glyceryl rosinate and glyceryl hydrogenated rosinate are esters of glycerin and acids derived from rosin, and rosin is obtained from trees of various species of Pinus

General safety info about Glyceryl Isostearate from CIR

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 44 monoglyceryl monoesters that are structurally-constituted of the esterification products of glycerin and carboxylic acids (the majority of which are fatty acids); 36 of these monoesters were previously-reviewed by the Panel, and 8 are reviewed for the first time. Most of the monoglyceryl monoester have several functions in cosmetics, but the most common function among the ingredients is skin conditioning agent; a few are reported to function only as surfactant – emulsifying agents. The Panel reviewed relevant new data, including frequency and concentration of use, and considered the data from previous CIR reports. The Panel concluded these ingredients are safe in cosmetics in the present practices of use and concentration described in this safety assessment.

Use this, not that!

Products where you might find Glyceryl Isostearate

Beautycounter Counter+ All Bright C Serum; Farmacy Very Cherry Bright 15% Clean Vitamin C Serum with Acerola Cherry; Anastasia Beverly Hills Lash Brag Volumizing Mascara