Grape Seed Extract

The Basics On Grape Seed Extract

What is Grape Seed Extract?

Grape seed extract has been shown to help diminish free-radical damage.

What are other names for Grape Seed Extract?

EXTRACT OF GRAPE SEED, EXTRACT OF VITIS VINIFERA SEED, GRAPE SEED EXTRACT, VITIS VINIFERA (GRAPE SEED) EXTRACT, VITIS VINIFERA (GRAPE) SEED EXTRACT, and VITIS VINIFERA SEED EXTRACT

What is Grape Seed Extract used for?

Grape Seed Extract is a great source of anti-oxidants, Vitamin C & Vitamin E which will help protect the skin from harmful irritants such as UV light, pollution, sun damage, smoke, and free radicals. Grape Seed Extract on its own has many anti aging properties to help fight the battle against fine lines and wrinkles.

How Grape Seed Extract is classified

Antioxidants, Plant Extracts

Recommendations for using Grape Seed Extract during pregnancy and breastfeeding

Limited data suggests no known risk

 

Grape Seed Extract During Pregnancy

What we know about using Grape Seed Extract while pregnant or breastfeeding

Limited information available.

Published reproductive and developmental toxicity data were not found for Vitis Vinifera (Grape)-derived ingredients. A reproduction study on grape color extract is described below. Information on estrogenic activity of some of the constituents of Vitis vinifera is provided in Table 6. Grape Color Extract A two-generation reproductive study on grape color extract was performed using Sprague-Dawley rats.29 (The Code of Federal Regulations (21CFR73.169) states that the color additive grape color extract is an aq. solution of anthocyanin grape pigments made from Concord grapes (Vitis labrusca) or a dehydrated water soluble powder prepared from the aq. solution. The aq. solution is prepared by extracting the pigments from precipitated lees produced during the storage of Concord grape juice. It contains the common components of grape juice, namely anthocyanins, tartrates, malates, sugars, and minerals, etc., but not in the same proportion as found in grape juice. The dehydrated water soluble powder is prepared by spray drying the aq. solution containing added malto-dextrin). Groups of 25 male and 25 female rats (F0 generation) were fed diets containing 0, 7.5, or 15% (w/w) grape color powder or a diet containing 9% by wt malto-dextrin for 3 wks; after 3 wks, the rats were mated within their respective groups. Female F0 rats, which were allowed to deliver, were fed the test diets throughout mating, gestation, and lactation. Each litter (the F1 generation) was culled to 10 pups (5 males and 5 females if possible) on day 4. On day 21 of lactation, two F1 males and two F1 females were selected for a subsequent 13-wk study followed by a reproduction study. The F0 parents and the remaining offspring were killed. The selected F1 animals were fed the same dietary levels of grape color extract as their parents. After 13 wks of dosing, the rats were mated within their respective groups. The F1 rats were also allowed to deliver and were fed the test diets throughout mating, gestation, and lactation. The F2 generation litters were culled as described above. On day 21 of lactation, all F1 parents and F2 pups were killed. All animals, except one F1 male of the malto-dextrin group, survived until scheduled termination. Dietary administration of up to 15% grape color powder had no effect on reproductive parameters or fertility. Body weights of the F1 and F2 pups of both test groups were statistically significantly decreased compared to controls at day 21 of lactation. Also, compared to controls, the body weights of F0 pups of the high-dose group were statistically significantly decreased on day 4, while the body weights of F1 pups of both test groups were statistically significantly decreased at birth. No microscopic lesions were reported in any of the groups. In the F1 animals fed the test diets for 13 wks prior to dosing, the group mean body weight gain was statistically significantly decreased in the high dose females. Statistically significant differences in several clinical chemistry parameters were observed between groups after 6 wks of dosing; the values were comparable at the end of 13 wks of dosing. The following statistically significant differences were recorded at necropsy regarding body and organ weights of the F1 animals: body weights of the high dose animals were decreased; absolute and relative liver weights were decreased in males and females of both test groups; absolute adrenal gland weights were decreased in males of both test groups and high-dose females; and relative thyroid gland weights were decreased in males of both test groups.

General safety info about Grape Seed Extract from CIR

The Expert Panel assessed the safety of 24 Vitis vinifera (grape)-derived ingredients and found them safe in the present practices of use and concentration in cosmetics. These ingredients are most frequently reported to function in cosmetics as skin conditioning agents. Some of these ingredients are reported to function as antioxidants, flavoring agents, and/or colorants. The Panel reviewed the available animal and clinical data to determine the safety of these ingredients. Additionally, some constituents of grapes have been assessed previously for safety as cosmetic ingredients; others are compounds that have been discussed in previous CIR safety assessments.

Use this, not that!

Products where you might find Grape Seed Extract

BeautyRx Skincare Dermstick for Pores (0.14 oz.); Naturopathica Milk Thistle Cleansing Tincture (1.7 fl. oz.); NARS Radiant Creamy Concealer; NARS Radiant Creamy Concealer Mini; Dermalogica Skin Smoothing Cream Moisturizer