Hexylene Glycol

The Basics On Hexylene Glycol

What is Hexylene Glycol?

What are other names for Hexylene Glycol?

1,1,3-TRIMETHYLTRIMETHYLENEDIOL, 2,4-DIHYDROXY-2-METHYLPENTANE, 2,4-PENTANEDIOL, 2-METHYL-, 2,4PENTANEDIOL, 2METHYL, 2-METHYL- 2,4-PENTANEDIOL, 2-METHYL-2,4-PENTANDIOL, 2-METHYL-2,4-PENTANEDIOL, 2-METHYLPENTANE-2,4-DIOL, HEXYLENE GLYCOL, HEXYLENE GYCOL, and MPD

What is Hexylene Glycol used for?

Hexylene Glycol is a solvent and viscosity agent used in many skin care products. It is used to thin out heavy compositions and create a thinner, more spreadable product.

How Hexylene Glycol is classified

Slip Agents

Recommendations for using Hexylene Glycol during pregnancy and breastfeeding

Limited data suggests no known risk

 

Hexylene Glycol During Pregnancy

What we know about using Hexylene Glycol while pregnant or breastfeeding

Limited information available.

Developmental and reproductive toxicity studies were conducted in animals that were orally exposed to several alkane diols reviewed in this safety assessment. In rat studies evaluating Propanediol at dose rates up to 1000 mg/kg/day, spermatogenic endpoints were unaffected (90-day exposure duration) 71 and no maternal (dosing on days 6-15 of gestation) or fetal toxic effects were observed (maternal and fetal NOAEL of 1000 mg/kg/day). 42 In a mouse study evaluating 1,4-Butanediol at up to 600 mg/kg/day, a maternal and developmental NOAEL of 100 mg/kg/day and a LOAEL of 300 mg/kg/day were reported; maternal central nervous system intoxication (300-600 mg/kg/day) and maternal and fetal body weight reduction (maternal 300-600 mg/kg/day) were observed.72 Results were mixed in rat studies evaluating 1,4-Butanediol. For males and females dosed with up to 800 mg/kg/day (14 days prior to mating and for females through day 3 of lactation), the following were reported: a reproductive parental and developmental NOAEL of 800 mg/kg/day, 57,68 a maternal toxicity NOAEL of 200 mg/kg/day, and a developmental toxicity/ teratogenicity NOAEL of 400 mg/kg/day.57 A maternal and developmental NOAEL of 1000 mg/kg/day was reported in animal studies on Hexanediol (rats dosed on days 6-19 of gestation)63 and for Methylpropanediol (rats dosed on days 0-20 of gestation; rabbits dosed on days 0-29 of gestation).18,73 In a rat study evaluating Butyl Ethyl Propanediol up to 1000 mg/kg/day (dosing on days 6-19 of gestation) a maternal NOAEL of 150 mg/kg/day (reduced activity, staggering, limb dragging, slow respiration, and reduced food consumption/body weight observed with 1000 mg/kg dose) and a developmental NOAEL of 1000 mg/kg/day were reported.65

General safety info about Hexylene Glycol from CIR

No report found.

Use this, not that!

Products where you might find Hexylene Glycol

REN Clean Skincare Glycol Lactic Radiance Renewal Mask; Sol de Janeiro Brazilian Bum Bum Cream; Sol de Janeiro Mini Brazilian Bum Bum Cream