Honeysuckle Flower Extract

The Basics On Honeysuckle Flower Extract

What is Honeysuckle Flower Extract?

Plant extract that is a good source of flavonoids.

What are other names for Honeysuckle Flower Extract?

EXTRACT OF LONICERA JAPONICA, JAPANESE HONEYSUCKLE EXTRACT, LONICERA (HONEYSUCKLE) EXTRACT, LONICERA EXTRACT, LONICERA JAPONICA (JAPANESE HONEYSUCKLE) EXTRACT, LONICERA JAPONICA (JAPANESE HONEYSUCKLE) FLOWER EXTRACT, LONICERA JAPONICA EXTRACT, and LONICERA JAPONICA FLOWER EXTRACT

What is Honeysuckle Flower Extract used for?

The extract is also rich in flavonoids and saponins, which are sources of antioxidants and protect the skin against free radicals that cause damage and signs of aging. Plus, honeysuckle is known to improve uneven skin tone and dullness. And because it’s anti-bacterial, honeysuckle can serve as a natural cleanser, too.

How Honeysuckle Flower Extract is classified

Skin-Soothing, Plant Extracts

Recommendations for using Honeysuckle Flower Extract during pregnancy and breastfeeding

Limited data suggests no known risk

 

Honeysuckle Flower Extract During Pregnancy

What we know about using Honeysuckle Flower Extract while pregnant or breastfeeding

Limited information available.

Dermal Overman (1985) reported the absence of embryotoxic effects of Formaldehyde after percutaneous exposure in hamsters. Golden Syrian hamsters of -100 g were individualls bred and the times of onset and completion of mating were noted and the midpoint designated time 0. On days 8, 9, 10, or 11 of gestation, 0.5 ml of Formaldehyde (37%) was applied to the clipped dorsol skin of anesthetized (to prevent licking) animals. Controls received water, but were otherwise treated in an identical fashion. Fetuses were recovered by laparotomy under general anesthesia at gestation day 15. Fetuses were weighed and examined for malformations. The author reported signs of stress in dams greater than previously seen in tests of other agents tested by this method. No significant effect on maternal weight gain or on fetal weight or length was seen. The percent implantation sites resorbed was 0 in the controls, but 4.2, 8.1, 4.6, and 3.2 with Formaldehyde treatment on gestation days 8, 9, 10, and 11, respectively. Two fetuses from the same litter in the day 8 group were significantly smaller than their littermates, as were 2 fetuses from different litters in the day 10 group. One fetus in the day 10 group had a subcutaneous hemorrhage in the dorsal cervical region. No skeletal malformations were found, nor were any other malformations observed. The author concluded that accidental skin exposure to formaldehyde likely would not adversely affect development (Overman, 1985). Inhalation 43 Saillenfait et al. (1989) reported the effects of maternally inhaled Formaldehyde on embryo and fetal development in rats. Pregnant Sprague-Dawley rats were exposed to Formaldehyde (5, 10, 20, or 40 ppm, 6 h/day) from gestation days 6 to 20. Control animals breathed room air. There were 25 rats per group. Dams were killed at term and the fetuses examined. All dams survived, however, there was a significant decrease in body weight gain in the 40 ppm group. There was a significant increase in body weight gain in the 5 ppm group was not considered treatment related. There were no significant differences in the implantations, resorptions, dead and live fetuses, incidence of pregnancy, or fetal sex ratio. There were significant dose related decreases in fetal body weights in male fetuses at 20 ppm (p < 0.05) and in both sexes at 40 ppm (p < 0.01). No significant increases in external, visceral, or skeletal abnormalities were seen. A non-significant increase in unossified vertebrae occurred in the 40 ppm group. The authors concluded that Formaldehyde exposure to rats under these conditions was not teratogenic, but is slightly fetotoxic at concentration levels that are not maternally toxic (Saillenfait et al., 1989). Martin (1990) reported a teratology study of inhaled formaldehyde in the rat. An initial rangefinding study involved 30 mated Sprague-Dawley rats. The rats were treated with 0, 2, 5, 10, or 16 ppm Formaldehyde from gestation day 6 to 15, 6 h/day. No maternal or fetal deaths occurred during this study. In the main study design, groups of 25 rats were treated with Formaldehyde at 2, 5, or 10 ppm, 6 h/day from gestation day 6 to 15, with two control groups (one handled the same as the treated animals and one left constantly in the animal room). Group mean values ± SD were calculated for body weights, food consumption, gravid uterine weights, and corrected body weights. Group mean values ± SD for litter size, corporus luteum count, number of implants, and resorptions were determined. Individual and group mean values ± SD for preimplantation and postimplantation losses were calculated. The litter sex ratio and the group sex ratio and the litter mean fetal weights and group mean fetal weights were determined. No tabular data were provided, however. According to the author, Formaldehyde had no effect on any of the above parameters, except a significantly decreased weight gain and reduced food consumption in dams at the 10 ppm level and a 44 significant decrease in ossification in the bones of the pelvic girdle in the fetuses at the 5 and 10 ppm levels. The latter finding was linked to larger litter sizes and slightly lower fetal weights in both the 5 and 10 ppm groups and was dismissed as not an adverse effect associated with Formaldehyde exposure (Martin, 1990). Intraperitoneal Majumder and Kumar (1995) reported that Formaldehyde injections produced inhibitory effects on the reproductive system of male rats. Adult male Wistar rats were given 10 mg/kg intraperitoneally by injection over a period of 30 days. A control group received water injections. On day 31, the animals were killed and the testis, prostate, seminal vescicles, and epididymis were removed and weighed. DNA and protein content was determined from tissue homogenates. The cauda portions of the epididymis were minced separately to obtain a sperm suspension. Sperm count, motility and viability were determined. In addition to the animal study, a sperm suspension of untreated animals was incubated with various concentrations of Formaldehyde at ambient temperature for up to 3 h. In the in vitro study, no viable sperm were found after 60 minutes after incubation with 5 ng Formaldehyde. Incubation with 500 ng Formaldehyde reduced the time for no viable sperm to 30 minutes. At 2500 ng Formaldehyde, the time was 10 minutes. Sperm motility was eliminated within 10 minutes at 5 ng Formaldehyde and within 30 minutes at 0.125 ng Formaldehyde. In vivo, there was a significant decrease in tissue DNA content in the testis (p < 0.0001) and the prostate (p < 0.001). The sperm count, viability and motility all decreased (p < 0.0001). The authors speculated that these findings could be attributed to a decrease in Leydig cell population, inhibition of spermatogenesis, and degeneration and calcification of testicular tissue (Majumdar and Kumar, 1995). Critical Reviews Collins et al. (2001b) reviewed the adverse pregnancy outcomes and Formaldehyde exposures in human and animal studies. The animal portion will be summarized here. Animals studies are reported in rats, mice, dogs, and hamsters using a variety of exposure routes. The authors state that studies using routes of exposure such as subcutaneous, intramuscular, and intraperitoneal injection do not provide data relevant to assessing human risk. Oral studies in rats, they contend, are iffy because rats dosed by 45 gavage exhibit micronuclei and nuclear abnormalities in the g.i. epithelium, the first site of contact. Inhalation and topical studies were considered relevant. The inhalation studies, mostly, find no increased risk at exposure ranges occurring in the workplace (e.g. the Saillenfait et al. 1989 study described above). Two Russian studies, however, did report long-term, whole-body inhalation studies in which maternal and embryo/fetal effects and female germ cell and bone marrow toxicity in rats. These reports have not been replicated and are typical of many Russian studies in lacking detailed study information. These authors recount the developmental toxicity from topical application in the form of increased resorptions and birth defects in hamsters in a pilot study and increased resorptions in the main study by Overman (1985) discussed above. These authors, however, point out that these studies were confounded by the stress experienced by the dams. Overall, the large number of inhalation, ingestion, and topical studies, according to these authors, provide little evidence of Formaldehyde reproductive or developmental toxicity under routes of exposure or levels of exposure relevant to the workplace. Thrasher and Kilburn (2001) also presented a review of embrotoxicity and teratogenicity of Formaldehyde. Included in this review was a description of several Japanese studies of the uptake of radiolabeled Formaldehyde injected into the tail veins of pregnant mice. The radiolabel was rapidly taken up into the maternal liver, lung, heart, salivary gland, gall bladder, spleen, kidney, bone marrow, nasal mucosa, uterus, placenta, and fetal tissues. The incorporation into placenta, uterus, and fetal tissues was larger than in other maternal organs and elimination of radiolabel was slower than from maternal tissues. These authors also present the results of the Russian study noted in the previous review which found female germ cell and bone marrow toxicity in rats. Exposures of female rats were 4 h/day, except on non-working days, for 4 months to 0.5 or 1.5 mg/m Formaldehyde vapor. The animals were mated with 3 untreated males and the embryos obtained on days 2 and 3 of pregnancy. Bone marrow was taken from the same animals 48 Р72 h after the end of Formaldehyde exposure and prepared for cytogenetic analysis in the normal way. All chromosome aberrations (not including gaps) were scored from 100 metaphases per animal. No significant effect of the low exposure on embryonic development was seen, but at the high 46 exposure there was blastomere structural damage (e.g., pyknosis of nuclei) and there was an increase in degenerating embryos (p < 0.05). In the bone marrow arm, the number of cells with aberrations was increased at the lower exposure (p < 0.05) and even more so at the higher exposure (p < 0.01). The number of chromatid and chromosome aberrations per 100 metaphases was increased at the high exposure level (p < 0.05). The number of chromosomes with aberrations and aneuploidy (<42) was elevated at both exposure levels. The mitotic index was decreased at the lower exposure level and increased at the higher (p < 0.05). This review also considers the Russian studies which found maternal and embryo/fetal effects. Female rats inhaled 0.012 or 1.0 mg/m Formaldehyde for 10-15 days and were mated with unexposed 3 males, then exposed again throughout gestation. Exposed animals were killed at parturition. No critical comments on the study were provided in this review, and the original study’s authors statements of increased pregnancies, decreased litter size, decreased ascorbic acid content of the fetus and maternal liver, increase in fetal body weight, increase in fetal organ weights (except for a decrease in lung an liver) are simply presented. This review also reports the Russian data on changes in fetal enzyme activity associated with Formaldehyde exposure, including MDH, SDH, and LDH decreases and GDH increase in mitochondria, and adenosine triphosphatase increase and inosine diphosphatase and â-glucuronidase decreases in lysosomes. N-Acetyleneuraminic acid levels increased in maternal and fetal tissues. The changes in enzyme activity and N-acetyleneuraminic acid correlated with increased fetal mortality. Development of postnatal behavior was also adversely affected. Finally, this review article presents a Russian study of the embryotoxic and teratogenic effects of Formaldehyde (inhalation of 0.5 mg/m , 4 h/day during gestation days 1-9) in rats with a background of 3 induced iron/trace-element disorder. A chelating agent was injected in 25% ethanol to induce iron deficiency. In animals receiving Formaldehyde alone, post-implantation mortality was increased, along with hydrophenosis cryptochordism anomalies, and the overall number of embryos with anomalies was increased. In animals receiving Formaldehyde and the chelating agent, post-implantation mortality was increased, and cleft palate, hydrophenosis, cryptochordism, and phocomelia (rear limbs) anomalies, breast 47 bone, digits, and tail cartilages adhesions, and the overall number of embryos with anomalies was increased (Thrasher and Kilburn, 2001).

General safety info about Honeysuckle Flower Extract from CIR

The report selectively reviews the extensive literature available on the toxicity of Formaldehyde. It is concluded that Formaldehyde in cosmetic products is safe to the great majority of consumers. Because of the skin sensitivity of some individuals to this agent, the formulation and manufacture of a cosmetic product should be such as to ensure use at the minimal effective concentration of Formaldehyde, not to exceed 0.2% measured as free Formaldehyde. It cannot be concluded that Formaldehyde is safe in cosmetic products intended to be aerosolized.

Use this, not that!

Products where you might find Honeysuckle Flower Extract

skyn ICELAND Icelandic Relief Eye Cream with Glacial Flower Extract (0.49 oz.); skyn ICELAND Oxygen Infusion Night Cream with Glacial Flower;GROWN ALCHEMIST Intensive Hand Cream – Persian Rose & Argan Extract (2.29 oz.) Extract (1.98 oz.); Kiehl’s Since 1851 Calendula Herbal Extract Alcohol Free Toner; AERIN Mediterranean Honeysuckle; Kiehl’s Since 1851 Calendula Herbal Extract Alcohol Free Toner Mini