Hops

The Basics On Hops

What is Hops?

Hops are the flowers of the hop plant Humulus lupulus.

What are other names for Hops?

HOP POWDER, HOPS, HUMULUS LUPULUS, HUMULUS LUPULUS (HOP), and HUMULUS LUPULUS (HOPS)

What is Hops used for?

Found in several anti aging skin care products, hops extract is a natural herb that can be used as a skin calming agent. … Because they are high in tannins, Hops also has powerful anti-inflammatory qualities for the skin that can help reduce the appearance of scarring and fade old acne marks.

How Hops is classified

Antioxidants, Plant Extracts

Recommendations for using Hops during pregnancy and breastfeeding

Limited data suggests no known risk

 

Hops During Pregnancy

What we know about using Hops while pregnant or breastfeeding

Limited information available.

Developmental and reproductive toxicity data on Humulus lupulus (hops)-derived ingredients were not found in the published literature and no unpublished data were submitted.

General safety info about Hops from CIR

This is a safety assessment of Humulus Lupulus (Hops) Extract and Humulus Lupulus (Hops) Oil as used in cosmetics. Both of these ingredients are derived from the strobile of the Humulus lupulus plant, commonly called hops. The reported functions of Humulus Lupulus (Hops) Extract in cosmetics include antimicrobial agent, hair conditioning agent, and skin-conditioning agent ‚Äì miscellaneous; Humulus Lupulus (Hops) Oil is reported to function as a fragrance ingredient. Previously, the wINCI listed four other names for Humulus Lupulus (Hops) Extract. Data submitted under those deleted names have been assigned to Humulus Lupulus (Hops) Extract and the deleted names are now technical names for Humulus Lupulus (Hops) Extract. Humulus lupulus (hops) strobile is an ingredient in food (most commonly in beer) and most of the other parts of this plant (shoots, leaves, flowers, seeds, rhizomes, and essential oils) are edible. The FDA determined that essential oils, oleoresins (solvent-free), and natural extractives (including distillates) of Humulus lupulus L. (hops) are GRAS for human consumption. Humulus lupulus (hops) plants are reported to contain several constituents of concern, including 8-PN, Œ≤-myrcene, and quercetin; these constituents could result in estrogenic activity, dermal irritation, and genotoxicity, respectively, if concentrations were high enough. Geraniol, limonene, linalool, and sesquiterpene lactones are potential dermal sensitizers. Humulus Lupulus (Hops) Oil is reported to contain sesquiterpene lactones. The butylene glycol extract of Humulus Lupulus (Hops) Extract is reported to contain no detectable Œ≤-myrcene. A product mixture that contains approximately 0.18% Humulus Lupulus (Hops) Extract is reported to have a theoretical content of Œ≤-myrcene of 0.0022% based on the content of the starting materials; it is noted that the method of manufacture does not favor Œ≤-myrcene retention. The Humulus lupulus (hops)-derived ingredients were reported to the VCRP database and surveyed by the Council in 2015(and updated in 2016) under the revised INCI names, and that is how they are reported herein. According to VCRP data received in 2017, Humulus Lupulus (Hops) Extract was reported to be used in 375 formulations, including 317 leave-on formulations and 54 rinse-off formulations. The results of the concentration of use survey conducted by the Council in 2015 (and updated in 2016) indicate that the highest reported maximum concentration of use of Humulus Lupulus (Hops) Extract is up to 0.2% in hair conditioners. Humulus Lupulus (Hops) Oil is not in use according to the VCRP and the industry survey. Rats fed a low-fat diet, a high-fat diet, or high-fat diet supplemented with 1% xanthohumol-rich extract of Humulus lupulus (hops) extracts for 41 days and male mice fed a normal diet, a high-fat diet, or high-fat diets supplemented with 2% or 5% of various Humulus lupulus (hops) extracts for 20 weeks had no mortalities or adverse effects reported for any group. The additions of any of the Humulus lupulus (hops) extracts reduced the effects of the high-fat diet on weight gain. The weights of livers and mesenteric and epididymal adipose tissues of mice fed the supplemented high-fat diets were similar to those of the controls, as were the plasma glucose levels at the end of the test period. An aqueous Humulus Lupulus (Hops) Extract (10 to 400 mg/¬µL in ethanol) was weakly mutagenic (an increase in induced revertants 2 to 4 times the controls) to S. typhimurium with and without metabolic activation. In another assay, a Humulus Lupulus (Hops) Extract was not mutagenic to S. typhimurium and E. coli at up to 10,000 ¬µg/plate, with or without metabolic activation. A product mixture containing 5% Humulus Lupulus (Hops) Extract at 10% (0.05% hops in deionized water) was not mutagenic to S. typhimurium with or without metabolic activation. Historically, there is circumstantial evidence of potential estrogenic activity connected to Humulus lupulus (hops) Distributed for Comment Only — Do Not Cite or Quote exposure, including menstrual disturbances reported to be common among female Humulus lupulus (hops) harvesters. 8-PN has been shown to be the source of the estrogenic activity of Humulus lupulus (hops) plants. It mimics the action of 17Œ≤-estradiol, albeit with a lesser (10- to 20,000-fold) potency. In a 2-week cumulative irritation test of a product containing Humulus Lupulus (Hops) Extract (0.125%), the test product did not demonstrate a significant irritation potential in human skin. In a human patch test of a product containing Humulus Lupulus (Hops) Extract at 0.06% to 0.12%, the irritation index was 0.04 (out of 5) and the test article was rated a non-irritant. No adverse reactions were observed in a patch test of a product mixture that contains Humulus Lupulus (Hops) Extract (approximately 0.18%). The causative agents of Humulus lupulus (hops) plant-induced contact skin reactions have not been established. In Humulus lupulus (hops) harvesters, dermatitis has been attributed to mechanical abrasion by the rough hairs on the climbing stem. It has also been suggested that lupulin, the yellow powdery secretion of the glandular hairs on the scales of the strobiles, may be responsible for the irritation. In a human maximization test of a product containing Humulus Lupulus (Hops) Extract (0.125%), the test product did not demonstrate contact sensitization potential. An HRIPT of Humulus Lupulus (Hops) Extract (10%; extracted with butylene glycol) gave negative results. No reactions were observed in an HRIPT that was conducted of a product mixture that contains Humulus Lupulus (Hops) Extract (approximately 0.18%). There were no signs of irritation or sensitization in an HRIPT of a product mixture that contained Humulus Lupulus (Hops) Extract (approximately 5%). In vitro assays showed that products and product mixtures containing Humulus Lupulus (Hops) Extract up to 0.5% were predicted to be either non-irritating or slight ocular irritants. Humulus Lupulus (Hops) Extract was predicted to be a slight ocular irritant in HET-CAM and cornea fibroblast assays and a non-irritant in an EpiOcular assay. Another Humulus Lupulus (Hops) Extract was predicted to be non-irritating in an HET-CAM assay and to SIRC fibroblastic cells. In a 4-week use study of an eye cream that contained Humulus Lupulus (Hops) Extract (0.125%), the test material did not demonstrate potential for eliciting ophthalmic irritation. In a survey of farmers, exposure to Humulus lupulus (hops) was reported to cause the greatest number of skin problems; 14 of 73 (19.2%) of the farmers reported work-related skin symptoms, 11% of which were caused by Humulus lupulus (hops). There were one, two, three, and four positive SPTs to the following Humulus lupulus (hops) allergen preparations, respectively: cone extract in glycerol, cone extract in saline, leaf extract in glycerol, and leaf extract in saline. In a study of occupational respiratory disease in Humulus lupulus (hops) workers, using Workers’ Compensation claims filed by Humulus lupulus (hops) workers for respiratory disease, the incidence rate of respiratory disease in Humulus lupulus (hops) workers was 15 cases per 10,000 full-time workers, which was 30 times greater than the incidence rate for field vegetable crop workers. The authors concluded that occupational exposure to Humulus lupulus (hops) dust is associated with respiratory disease; respiratory disease rates were higher in hop workers than in a comparison group of agricultural workers. In a study of occupational exposure of brewery workers to organic dusts, including Humulus lupulus (hops), the potential to affect respiratory function and immunological status was examined. A large number of brewery workers complained of acute symptoms that developed during the work shift. Lung function tests were decreased compared to predicted levels. There was a greater instance of positive SPTs in brewery workers for Humulus lupulus (hops) than in controls (15% vs 3%). There were increased serum levels of total IgE in 34 of 97 (45.1%) brewery workers compared to controls, 1 of 76 (2.7%). However, workers with positive SPTs had a prevalence of chronic respiratory symptoms and lung function changes similar to those of workers with negative SPTs. The authors concluded that the data suggests that both smoking and dust exposure in the brewery industry may be responsible for the development of respiratory impairment and immunological reactions. There were case studies of subjects becoming sensitized to Humulus lupulus (hops) plants or the constituent Œ≤-myrcene while working with the plant on farms, laboratories, and in breweries.

Use this, not that!

Products where you might find Hops

TULA Skincare Glow Hour Brightening & Neutralizing Eye Balm (0.14 oz.); Ursa Major Golden Hour Recovery Cream (1.7 fl. oz.); Tarte Cosmetics Amazonian Clay 12-Hour Full Coverage Foundation SPF 15 – 22N Light Neutral (1.7 fl. oz.); Eve Lom Cleanser; HUM Nutrition Mighty Night Overnight Renewal Supplement; Better Not Younger Wake Up Call Volumizing Shampoo