Lauryl Lactate

The Basics On Lauryl Lactate

What is Lauryl Lactate?

Mixture of lauryl alcohol and lactic acid.

What are other names for Lauryl Lactate?

2-HYDROXY- DODECYL ESTER PROPANOIC ACID, 2-HYDROXYPROPANOIC ACID, DODECYL ESTER, DODECYL 2-HYDROXYPROPANOATE, DODECYL ESTER 2-HYDROXYPROPANOIC ACID, DODECYL ESTER LACTIC ACID, DODECYL ESTER PROPANOIC ACID, 2-HYDROXY-, DODECYL LACTATE, LACTIC ACID, DODECYL ESTER, LAURYL LACTATE, PROPANOIC ACID, 2-HYDROXY-, DODECYL ESTER, and PROPANOIC ACID, 2HYDROXY, DODECYL ESTER

What is Lauryl Lactate used for?

Lauryl Lactate is a naturally occurring acid known as an Alpha Hydroxy Acid (AHA) found in beauty products and cosmetics functioning as an emollient, skin conditioning agent, and exfoliant. It is also infrequently used to impart fragrance in some products

How Lauryl Lactate is classified

Fragrance: Synthetic and Fragrant Plant Extracts, Emollients

Recommendations for using Lauryl Lactate during pregnancy and breastfeeding

Limited data suggests no known risk

 

Lauryl Lactate During Pregnancy

What we know about using Lauryl Lactate while pregnant or breastfeeding

Limited information available.

A developmental toxicity study was conducted using Glypure 99% highpurity Glycolic Acid crystalline in which groups of 25 rats were dosed with 75-600 mg/kg of the test material in deionized water by gavage on days 7-21 of gestation (Haskell Laboratory, 1996). A control group was dosed with vehicle only Surviving dams were killed on day 22, and their fetuses were examined. Developmental toxicity was observed at doses of 300 and 600 mg/kg of 99% Glycolic Acid. In fetuses of the 300-mg/kgdose group, a slight, but non-statistically significant, increase was observed in the incidence of fused ribs and fused vertebrae. In fetuses of the 600-mg/kg-dose group, the incidence of fused ribs and fused vertebrae, as well as of absent ribs, abnormally fused and cleft sternebrae, hemi-vertebrae, misaligned and incompletely ossified sternebrae, and incompletely ossified vertebrae was significantly increased. Mean fetal weight was significantly reduced at this dose. Maternal toxicity was also observed at doses of 300 and 600 mg/kg of 99% Glycolic Acid. In dams of the 300-mg/kg group, lung noise was slightly increased. In dams of the 600-mg/kg group, lung noise was markedly increased, and abnormal gait, lethargy, and irregular respiration were observed and mean maternal body weight, weight change, and feed consumption were significantly reduced. No evidence of developmental or maternal toxicity was observed in animals of the 75- and 150-mg/kg-dose groups; therefore, the no-observed-effect-level was 150 mg/kg. It was the opinion of the researchers that collateral stress on the dam resulted in fetal damage and that Glycolic Acid itself was not a developmental toxin. A pilot developmental toxicity study was conducted using 70% Glycolic Acid technical solution (a grade that DuPont Specialty Chemicals (1995, 1996) states that they prohibit for use in personal care applications) in which groups of eight Crl:CD@BR gravid rats were dosed by gavage with 125, 250, 500, or 1000 mg/kg of the test material in distilled water at a volume of 10 mL/kg on days 7-21 of gestation (Haskell Laboratory, 1995). A control group was dosed with vehicle only. Clinical signs were recorded once or twice daily, and observations for morbidity and mortality were also made daily. The dams were weighed on days 1 and 7-22 of gestation. Surviving dams were killed on day 22 of gestation, and the fetuses were examined. Maternal toxicity was observed at doses of 500 International Journal of Toxicology, 17(Suppl. 1):119-121,1998 Copyright 0 1998 Cosmetic Ingredient Review 10!31-5818/98 $12.00 + .oo 119 120 REPRODUCTIVE AND DEVELOPMENTAL TOXICITY and 1000 mg/kg. Females of the 500-mg/kg-dose group had significant increases in the clinical observations of “wet chin” and “lung noise.” For this dose group, body weight changes were significantly reduced between days 21 and 22, but no other significant effects on body weight were observed; feed consumption was not affected at this dose. Abnormal gait and mobility, lung noise, salivation, and stained and wet haircoats were observed for dams of the lOOO-mg/kg-dose group. Body weight gains were significantly decreased at several intervals; maternal body weights for animals of this dose group were statistically significantly reduced (88% of control) on day 22. Feed consumption was also significantly reduced. One moribund female of the lOOO-mg/kg-dose group was killed. Ulcerations of the gastric mucosa, distended intestines, and mottled kidneys were observed at necropsy. No evidence of toxicity was observed for females of the 125- or 250- mg/kg-dose groups. Fetuses of the 500-mg/kg-dose group had statistically significantly decreased mean fetal weight, and the incidence of retarded sternebral ossification was statistically significantly increased. Fetuses of the lOOO-mg/kg-dose group had statistically significantly decreased mean fetal body weight, and the incidence of early resorptions, specific malformations (gastroschisis, hydrocephaly, fused ribs, fused vertebra(e), and hemivertebrace)), and specific variations (misaligned sternebrace) and retarded vertebral and sternebral ossification) were statistically significantly increased. No evidence of toxicity was noted for fetuses of the 125- or 250-mg/kg-dose groups. No dose-related effects were observed on reproductive parameters. The maternal and developmental no-observed-adverse-effect level was 250 mg/kg day-l. An in vitro embryo culture study was performed in which rat embryos were removed from the uterus and allowed to develop in culture medium. On day 10.5 of gestation, groups of 10 embryos were cultured for 46 h in medium containing 0.5, 2.5, 12.5, 25.0, or 50.0 mM Glycolic Acid. A control group was also cultured (Carney et al., 1996). No effects on embryo development were observed with 0.5 or 2.5 mM Glycolic Acid. At a concentration of 12.5 mM, crown-rump length, head length, embryo and visceral yolk sac protein content, somite number, and morphology score were significantly decreased. Structural abnormalities, mainly in the craniofacial region, were observed. Doses greater than 12.5 mM caused embryolethality. Sodium Glycolate, 12.5 mM at pH 7.42, caused effects similar to those seen with 12.5 mM Glycolic Acid, pH 6.74, but were of a lesser degree. Sodium Glycolate. In a 1943 General Foods Corporation embryotoxicity study, male and female rats (number not specified) were fed 2.5% Sodium Glycolate (duration of dosing not specified) and mated (Haskell Laboratory, 1990). The average age of test group dams at birth of the REPRODUCTIVE AND DEVELOPMENTAL TOXICITY 121 first young was 50% greater than that of the control dams. The number of young born was 65% less in the test group than in the control group, and the number of test group pups weaned was 4.4% as compared to 19.3% in the control group. Lactic Acid Twelve gravid Swiss albino CD-l mice were dosed daily with 570 mg/kg Lactic Acid by gavage on days 6-15 of gestation; a control group of 13 mice received distilled water (Colomina et al., 1992). All dams were killed on day 18 of gestation. No significant difference was observed in gestational body weight gain between test and control animals, but feed consumption was significantly decreased during days 6-9, 6-12, and 15-18 of gestation as compared to control values. Also, relative maternal liver weight was significantly decreased as compared to controls. The only observed effect on the fetus was a statistically significant increase in delayed ossification of the parietal bones. Rats were fed stock diet supplemented with 2.5 or 5% Lactic Acid or untreated stock diet to determine the effect of Lactic Acid on the sex ratio in rats @‘Amour, 1934). The sex ratio of rats was not affected by oral administration of Lactic Acid. Sodium Lactate. Sodium Lactate, 5 mM, was added to B&F1 mice pre-embryo cultures to examine its effect on the development of these cells over a 72-h period; a control group was cultured in medium alone (Moley et al., 1994). No significant difference was observed in the overall rate of development between embryos cultured in the presence of Sodium Lactate as compared to those cultured in medium alone. No difference was found in the distribution of pre-embryo growth stages. TEA-Lactate, Published teratogenicity data for TEA-Lactate were not found. A study included in the Safety Assessment on TEA (Elder, 1983) reported that topical application of TEA to pregnant rats did not produce teratogenic effects.

General safety info about Lauryl Lactate from CIR

This report provides a review ofthe safety of Glycolic Acid, Ammonium, Calcium, Potassium, and Sodium Glycolates, Methyl, Ethyl, Propyl, and Butyl Glycolates, Lactic Acid, Ammonium, Calcium, Potassium, Sodium, and TEA-Lactates, and Lauryl, Myristyl, and Cetyl Lactates. These ingredients belong to a group known as alpha-hydroxy acids (‘As). Products containing these ingredients may be for consumer use, salon use, or medical use. This report does not address the medical use. In consumer and salon use, AHAs can function as mild exfoliants, but are also used as pH adjusters and skin-conditioning agents. AHAs are absorbed by the skin; the lower the pH, thegreater the absorption. Metabolism and distribution studies show expected pathways and distribution. Consistent with these data, acute oral animal studies show oxalate-induced renal calculi, an increase in renal oxalate, and nephrotoxic effects. No systemic effects in animals were seen with dermal application, but irritation at the sight of application was produced. While many animal studies were performed to evaluate AIXA-induced skin irritation, it was common for either the AHA concentration or the pH of the formulation to be omitted, limiting the usefulness of the data. Clinical testing using AHA formulations of known concentration and pH was done to address the issue of skin irritation as a function of concentration and PH. Skin irritation increased with AHA concentration at a given PH. Skin irritation increased when thepHofagivenAHAconcentration was lowered. Repeat insultpatch tests using lotions and creams containing up to 10% Glycolic or Lactic Acid were negative. Glycolic Acid at concentrations up to 10% was not comedogenic and Lactic Acid at the same concentrations did not cause immediate urticarial reactions. Glycolic Acid was found to be nonirritating to minimally irritating in animal ocular tests, while Lactic Acid was found to be nonirritating to moderately irritating. In vitro testing to predict ocular irritation suggested Glycolic Acid would be a minimal to moderate-severe ocular irritant, and that Lactic Acid would be a minimal to moderate ocular irritant. Developmental and maternal toxicity were reported in rats dosed by gavage at the highest dose level used in a study

Use this, not that!

Products where you might find Lauryl Lactate

Summer Fridays Super Amino Gel Cleanser, Peter Thomas Roth Peptide 21 Amino Acid Exfoliating Peel Pads, Guerlain Midnight Secret Late Night Recovery Treatment Anti-Fatigue Serum