Magnesium Laureth Sulfate

The Basics On Magnesium Laureth Sulfate

What is Magnesium Laureth Sulfate?

Magnesium salt of laureth sulfate, which is in turn the ester of laureth and sulfuric acid; used as a mild detergent cleansing agent, often for people with sensitive skin.

What are other names for Magnesium Laureth Sulfate?

MAGNESIUM LAURETH SULFATE, MAGNESIUM LAURYL ETHER SULFATE, and POLY(OXY1,2ETHANEDIYL), αSULFOω(DODECYLOXY), MAGNESIUM SALT

What is Magnesium Laureth Sulfate used for?

How Magnesium Laureth Sulfate is classified

Cleansing Agents

Recommendations for using Magnesium Laureth Sulfate during pregnancy and breastfeeding

Limited data suggests no known risk

 

Magnesium Laureth Sulfate During Pregnancy

What we know about using Magnesium Laureth Sulfate while pregnant or breastfeeding

Limited information available.

Animal The following doses of magnesium sulfate were administered to Crj:CD(SD) female rats s.c. three times per day on days 15 through 20 of gestation: 250, 500, and 1,000 mg/kg.27 The control group and 250 mg/kg group each consisted of 19 rats. The remaining 2 dose groups each contained 20 rats. Effects of the test material on the dams and F1 animals were examined. Dams dosed with 500 and 1,000 mg/kg had decreased food consumption, Hypolocomotion, pronation, bradypnea, and decreased body weight gain were observed in the 1,000 mg/kg dose group. There were no test material-related effects on delivery or lactation, and necropsy results were normal. Results for F1 animals dosed with 1,000 mg/kg were as follows: low body weight, delays in differentiation (eruption of lower incisor and opening of eyelid), and reversible changes in ribs (wavy ribs). However, there were no test material-related effects on viability, functional examinations, behavioral tests, or reproductive ability. It was concluded that the NOAEL for general toxicological effects on the dams was 250 mg/kg/day (3 times per day), and that the NOAEL for reproductive ability and development were 1,000 mg/kg/day (3 times per day) and 500 mg/kg/day (3 times per day), respectively. Human Over a period of 14 years, 7,000 infants were born to mothers who had received magnesium sulfate parenterally because of preeclampsia or eclampsia.28 A 50% magnesium sulfate (MgSO4·7H2O, USP) solution was injected intramuscularly (30 to 40 g doses, during 24 h) into the gravida. This regimen was continued as long as the mother had demonstrable knee jerks, urine output of at least 100 ml during 4 h, and no depression of respiration. The serum level of magnesium in the fetus rapidly approached the maternal level, but could not be correlated with any adverse effect. Dosing did not have any observable deleterious effects on the fetus or newborn. Five neonates were born to mothers who had been treated i.v. with magnesium sulfate for tocolysis.29 The neonates were retrospectively reviewed to assess the presence of radiographic, clinical, and biochemical abnormalities. Two infants had radiographic bony abnormalities; one had frank rachitic changes and dental enamel hypoplasia. One of these patients as well as an additional infant had transient hypocalcemia. It was hypothetized that prolonged infusion of magnesium sulfate, especially when initiated during the second trimester, may lead to fetal parathyroid gland suppression, with consequent abnormalities resembling rickets. The effects of maternal magnesium sulfate treatment on newborns were studied.30 The subjects in this study were newborn infants, delivered at ≥ 34 weeks of gestation, whose mothers had received a minimum of 12 h of i.v. magnesium sulfate therapy prior to delivery. A total of 26 magnesium-exposed and 26 control infants was enrolled. The mean dose of magnesium sulfate prior to delivery was 51.2 ± 24 g, and the mean duration of therapy was 23.1 ± 120 h. The mean maternal serum magnesium level before delivery was 5.8 ± 1.1 mg/dl. Infants exposed to magnesium sulfate in utero had a higher incidence of hypotonia and lower median Apgar scores, compared to control infants (p < 0.001). However, there was no association between adverse outcomes and maternal serum magnesium concentrations at the time of delivery, duration of treatment, or dose of magnesium sulfate. Pneumocardiogram data were similar between magnesium sulfate-exposed and control infants (all, p ≥ 0.16). In a controlled trial, mothers in preterm labor were randomized as follows: magnesium sulfate tocolysis (46 mothers, 55 newborns) and saline control (28 mothers, 29 newborns).31 Magnesium sulfate was administered as a 4-g bolus, followed by infusion of 2 to 3 g of magnesium sulfate per hour. Children with adverse outcomes had higher umbilical cord magnesium levels at the time of delivery. In regression models that controlled for confounders, which included very low birth weight, magnesium remained a significant risk factor (adjusted odds ratio = 3.7; 95% CI of 1.1 to 11.9; P = 0.03). Dosing with magnesium sulfate was associated with 11 composite adverse pediatric outcomes, which included intraventricular hemorrhage (IVH) and periventricular leucomalacia (PVL), and cerebral palsy. However, the differences in this trial were not statistically significant (magnesium sulfate: 37% [11 adverse events in 30 infants]; saline solution: 21% [6 adverse events in 29 infants] (P = 0.25). Between January 2000 and February 2009, 6,654 women with preeclampsia were treated with an intravenous infusion of magnesium sulfate, with the goal of achieving a therapeutic range of 4 to 7 mE/L (2.0 to 3.5 mmol/L).32 Eightyeight infants (6% of the infants) were diagnosed with hypotonia. Lowder 1-minute and 5-minute Apgar scores, intubation in the delivery room, admission to special care nursery, and hypotonia were all significantly increased as maternal serum magnesium concentrations increased prior to birth.

General safety info about Magnesium Laureth Sulfate from CIR

Magnesium Sulfate functions as a bulking agent in cosmetic products, and is being used at concentrations up to 11% and 25% in leave-on and rinse-off products, respectively. The CIR Expert Panel noted that the history of safe medical use of magnesium sulfate indicates no significant toxicity concerns relating to systemic exposure to these ingredients. Furthermore, the extensive clinical experience of the Panel, including the results of numerous patch tests, indicates that magnesium salts do not have the potential to induce sensitization. The Panel noted that salts of sulfuric acid, such as sodium sulfate, can be irritating to the skin, so cosmetic products containing magnesium sulfate should be formulated to be non-irritating. The Panel concluded that magnesium sulfate is safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating

Use this, not that!

Products where you might find Magnesium Laureth Sulfate

The Nue Co. Magnesium Ease (30 ml.); REN Clean Skincare Atlantic Kelp and Magnesium Body Wash (10.2 fl. oz.); REN Clean Skincare Atlantic Kelp And Magnesium Salt Anti-Fatigue Exfoliating Body Scrub (11.2 fl. oz.); REN Clean Skincare Atlantic Kelp and Magnesium Anti-Fatigue Body Wash – 100% Recycled Plastic; REN Clean Skincare Atlantic Kelp and Magnesium Salt Anti-Fatigue Exfoliating Body Scrub;Caudalie Premier Cru Anti-Aging Rich Cream