Methyldibromo Glutaronitrile

The Basics On Methyldibromo Glutaronitrile

What is Methyldibromo Glutaronitrile?

Formaldehyde-releasing preservative.

What are other names for Methyldibromo Glutaronitrile?

1,2-DIBROMO-2,4-DICYANOBUTANE, 1-BROMO-1-(BROMOMETHYL)-1,3-PROPANEDICARBONITRILE, 2-BROMO-2-(BROMOMETHYL) GLUTARONITRILE, 2-BROMO-2-(BROMOMETHYL) PENTANEDINITRILE, 2-BROMO-2-(BROMOMETHYL)- GLUTARONITRILE, 2-BROMO-2-(BROMOMETHYL)- PENTANEDINITRILE, 2-BROMO-2-(BROMOMETHYL)PENTANEDINITRILE, GLUTARONITRILE, 2-BROMO-2-(BROMOMETHYL)-, METHYLDIBROMO GLUTARONITRILE, PENTANEDINITRILE, 2-BROMO-2-(BROMOMETHYL)-, and PENTANEDINITRILE, 2BROMO2(BROMOMETHYL)

What is Methyldibromo Glutaronitrile used for?

What is it? Methyldibromo glutaronitrile is primarily a preservative in skin care products, paints, and wood. Skin contact with Methyldibromo glutaronitrile is required for it to cause a rash.

How Methyldibromo Glutaronitrile is classified

Preservatives

Recommendations for using Methyldibromo Glutaronitrile during pregnancy and breastfeeding

Avoid

 

Methyldibromo Glutaronitrile During Pregnancy

What we know about using Methyldibromo Glutaronitrile while pregnant or breastfeeding

Limited information available.

Groups of -30 female rats (type not specified) were mated and administered either 0, 2.5, 100, or 175 mg/kg of Methyldibromo Glutaronitrile orally by gavage on days 6 through 15 of gestation. Dams were asphyxiated on day 20, and the fetuses were externally examined. Half of the fetuses from each litter were selected at random for internal examination. No pharmacological signs of maternal toxicity were observed. The mean number of implantations, fetal weights, and the incidence of malformations and developmental variants were not significantly affected by Methyldibromo Glutaronitrile. The average resorption rate was significantly higher in the 175 mgikg group than in the controls (10.0 vs. 2.7%). However. the researchers pointed out that 50% of the resorptions at the 175 mg/kg dosage were contained in two litters and that the 10.0% incidence was within the normal range for historical controls. Other signs of embryotoxicity such as malformations and fetal weight reductions were not observed (Birnbaum et al., 1983). A 90-day feeding study in rats was conducted by Hazleton Laboratories America (1980~). Groups of IO parental rats (of each sex) were exposed to Methyldibromo Glutaronitrile beginning 1 week before breeding and continuing throughout mating, gestation, and lactation. Doses were set at 83.5, 500, or 3,000 ppm. For 90 days after weaning, 20 offspring/sex/dosing group were fed diets containing the same exposure levels on which their respective parents had been maintained. No treatment-related clinical observations were noted in the parental generation. Of the F, generation, male pups of the treated groups had body weights comparable to controls. whereas high-dose female pups had lower body weights than controls. Low- and middose females had higher body weights on two observation days. No treatment-related ocular effects were noted. A slight increase in extramedullary hematopoiesis was observed in the spleens of females receiving 3,000 ppm Methyldibromo Glutaronitrile.

General safety info about Methyldibromo Glutaronitrile from CIR

The halogen compound Methyldibromo Glutaronitrile is used in a wide variety of cosmetics as a preservative. Concentrations in cosmetic formulations reportedly range from 0.0075 to 0.06%. The oral LD,, in rats is 640mg/kg. Dogs on a diet of 4,000 ppm Methyldibromo Glutaronitrile for 13 weeks developed thyroid hyperplasia; those on a diet of 167 ppm exhibited no hyperplasia, although the thyroid glands were enlarged. Application of Methyldibromo Glutaronitrile at a level of 4.0 g/kg to the skin of rats for 21 days produced severe irritation. A concentration of 0.025% applied to the skin of rabbits in a 28-day dermal toxicity study resulted in only slight to moderate irritation. No evidence of sensitization was found in guinea pig studies. nor was photosensitization reported in mouse studies. No reproductive or developmental toxicity was noted in two rat studies. Methyldibromo Glutaronitrile was not mutagenic in a series of mammalian system tests. Clinical data using repeat insult patch testing (HRIPT) methods indicated that concentrations as low as 0.025% produced a positive reaction in a few individuals. To limit the possibility that formulations containing this ingredient will lead to sensitization, it was concluded that leave-on formulations should contain ~0.025% Methyldibromo Glutaronitrile. Rinse-off formulations, because the duration of exposure is much less, are considered safe as currently used. Key Words: Methyldibromo Glutaronitrile-Cosmetic use-Repeat insult patch testing-Leave on formulation-Rinse-off formulation.

Use this, not that!

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Products where you might find Methyldibromo Glutaronitrile

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