Methylisothiazolinone

The Basics On Methylisothiazolinone

What is Methylisothiazolinone?

Preservative that’s generally recommended for use only in rinse-off products.

What are other names for Methylisothiazolinone?

2-METHYL- 3(2H)-ISOTHIAZOLONE, 2-METHYL-2H-ISOTHIAZOL-3-ONE, 2-METHYL-3(2H)-ISOTHIAZOLONE, 2-METHYL-4-ISOTHIAZOLIN-3-ONE, 3(2H)-ISOTHIAZOLONE, 2-METHYL-, 3(2H)ISOTHIAZOLONE, 2METHYL, METHYLCHLOROISOTHIAZOLINONE225METHYLISOTHIAZOLINONE SOLUTION, and METHYLISOTHIAZOLINONE

What is Methylisothiazolinone used for?

Methylisothiazolinone (MIT) and Methylchloroisothiazolinone (CMIT) are widely used preservatives found in liquid cosmetic and personal care products. Both chemicals inhibit bacterial growth in cosmetic products on their own, but they are most commonly used as a mixture in products.

How Methylisothiazolinone is classified

Preservatives, Sensitizing

Recommendations for using Methylisothiazolinone during pregnancy and breastfeeding

Avoid

 

Methylisothiazolinone During Pregnancy

What we know about using Methylisothiazolinone while pregnant or breastfeeding

Limited information available.

MI/MCI-886 (in aqueous solution) was administered by gavage to groups of 15 pregnant Dutch belted rabbits on days 6 through 18 of gestation at doses of 0, 1.5,4.4, and 13.3 mg/kg/day a.i. There were two control groups, one received distilled water Distributed for Comment Only — Do Not Cite or Quote 104 COSMETIC INGREDIENT REVIEW and the other received a magnesium-water solution. MI/MCI-886 was maternally toxic; 5/l 5, 12/l 5, and 14/l 5 dams died at the low, mid, and high doses, respectively. Signs of toxicity included ataxia, diarrhea, and severe gastric irritation. At Cesarean section of the surviving dams, a decrease in the number of live fetuses, and an increase in the number of resorption sites and postimplantation losses were observed. No visceral or skeletal malformations were found in the fetuses from any of the treated groups. The investigators concluded MI/MCI-886 was not teratogenic but was embryotoxic and fetotoxic if administered at doses that were highly toxic to rabbits.‚Äò30′ MI/MCI-886 (in aqueous solution) was administered by gavage to groups of 25 pregnant Sprague-Dawley rats on days 5 through 15 of gestation at doses of 1.5, 4.5, and 15 mg/kg/day a.i. The control groups received distilled water. MI/MCI-886 was maternally toxic; l/25, 2/25, and 3/25 dams died at the low-, mid-, and high-dose levels, respectively. Signs of toxicity included wheezing, alopecia, and gastric irritation. No treatment-related effects were noted in any of the reproductive parameters of the surviving dams and fetuses. Upon visceral examination, two exencephalic fetuses, one in the control group and one in the mid-dose group, were observed. No significant anomalies were found upon skeletal examination. The investigators concluded that MI/MCI-886 administered to rats at dosages up to 15 mg/kg/day a.i. was not teratogenic.‚Äò30′ MI/MCI-886 was administered in the drinking water to groups of 10 male and 10 female Charles River rats for 15 weeks. Concentrations administered were 0, 25, 75, and 225 ppm (equivalent to 0, 3, 8, and 20 mg/kg/day). Rats within the same dose groups were then mated. Maternal health as well as fetal health up to day 21 after delivery were monitored. No adverse effects on fertility, reproduction, fetal survival, or fetal health were observed.‚Äò30′

General safety info about Methylisothiazolinone from CIR

No report found.

Use this, not that!

Coming soon!

Products where you might find Methylisothiazolinone

Maison Louis Marie Le Bouquet Candle Trio Set; TAN-LUXE Wonder Oil Illuminating Self-Tan Oil; Maison Louis Marie Antidris Cassis Candle