Methylpropanediol

The Basics On Methylpropanediol

What is Methylpropanediol?

Glycol that functions as a solvent. Methylpropanediol can enhance ingredients such as salicylic acid.

What are other names for Methylpropanediol?

2-METHYL-1,3-PROPANEDIOL, B-HYDROXYISOBUTANOL, and METHYLPROPANEDIOL

What is Methylpropanediol used for?

In cosmetics, Methylpropanediol acts as a multipurpose ingredient (emollient, humectant, booster, solvent…). It has a soft and non-tacky feel and it is used to improve skin feel. In association with glycerine, it allows improved feeling and hydration of cosmetic cream.

How Methylpropanediol is classified

Miscellaneous, Hydration

Recommendations for using Methylpropanediol during pregnancy and breastfeeding

Limited data suggests no known risk

 

Methylpropanediol During Pregnancy

What we know about using Methylpropanediol while pregnant or breastfeeding

Limited information available.

Oral Developmental and reproductive toxicity studies were conducted in animals that were orally exposed to Propanediol, 1,4-Butanediol, Hexanediol, Methylpropanediol, or Butyl Ethyl Propanediol. In rat studies evaluating Propanediol at dose rates up to 1000 mg/kg/day, spermatogenic endpoints were unaffected (90-day exposure duration) 88 and no maternal (dosing on days 6 – 15 of gestation) or fetal toxic effects were observed (maternal and fetal NOAEL 1000 mg/kg/day). 12 In a mouse study evaluating 1,4-Butanediol at up to 600 mg/kg/day (dosing on days 6 – 15 of gestation), a maternal and developmental NOAEL of 100 mg/kg/day and a LOAEL of 300 mg/kg/day were reported; maternal central nervous system intoxication (300-600 mg/kg/day) and maternal and fetal body weight reduction (maternal 300 – 600 mg/kg/day) were observed.91 For male and female rats dosed with up to 800 mg/kg/day 1,4-Butanediol (14 days prior to mating and for females through day 3 of lactation), the following were reported: developmental NOEL of 400 mg/kg/day (pup weight slightly but statistically significantly decreased on lactation day 4 at 800 mg/kg/day, secondary to maternal reduction in body weight), parental transient hyperactivity (200 and 400 mg/kg/day) and reversible parental hypoactivity (‚â• 400 mg/kg/day), but no parental reproductive parameters were changed by treatment. 13,22 A maternal and developmental NOAEL of 1000 mg/kg/day was reported in animal studies on Hexanediol (rats dosed on days 6-19 of gestation)15 and for Methylpropanediol (rats dosed on days 0 – 20 of gestation; rabbits on days 0 – 29).2,32 In a rat study evaluating Butyl Ethyl Propanediol (up to 1000 mg/kg/day on days 6 – 19 of gestation), a maternal NOAEL of 150 mg/kg/day (reduced activity, staggering, limb dragging, slow respiration, and reduced food consumption/body weight at 1000 mg/kg dose) and a developmental NOAEL of 1000 mg/kg/day were reported.17

General safety info about Methylpropanediol from CIR

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 10 alkane diol ingredients as used in cosmetics. The alkane diols are structurally related to each other as small diols, and most are reported to function in cosmetics as solvents. The Panel reviewed the relevant data for these ingredients, and concluded that seven alkane diols are safe in cosmetics in the present practices of use and concentration described in this safety assessment, but that the available data are insufficient to make a determination of safety for three ingredients, namely 1,4-Butanediol, 2,3-Butanediol, and Octanediol.

Use this, not that!

Products where you might find Methylpropanediol

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