Panthenol

The Basics On Panthenol

What is Panthenol?

Alcohol form of the B vitamin pantothenic acid.

What are other names for Panthenol?

2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYL- BUTANAMIDE, 2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYLBUTANAMIDE, BUTANAMIDE, 2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYL-, BUTANAMIDE, 2,4DIHYDROXYN(3HYDROXYPROPYL)3,3DIMETHYL,(+/), D-PANTOTHENYL ALCOHOL, DEXPANTHENOL, DL-PANTOTHENYL ALCOHOL, PANTHENOL, PANTHENOL , DL-FORM, PANTOTHENOL, PANTOTHENYL ALCOHOL, and PROVITAMIN B5

What is Panthenol used for?

Panthenol is a chemical substance made from pantothenic acid, also known as vitamin B-5. It occurs organically and can also be produced from both plant and animal sources. It’s used as an additive in various cosmetic products around the globe. You very likely have pantothenic acid in your system right now, since it occurs in so many common food sources. And you’ve likely used a cosmetic or personal care product with panthenol within the last 24 hours. Panthenol takes the form of either a white powder or a transparent oil at room temperature. You will sometimes see panthenol listed under one of its other names on ingredients list, including: dexpanthenol D-pantothenyl alcohol butanamide alcohol analog of pantothenic acid provitamin B-5 When absorbed into the body, panthenol becomes vitamin B-5. In topical cosmetics, product manufacturers often use panthenol as a moisturizer. But it’s also included in many cosmetics as a softening, soothing, and anti-irritant agent. It also helps your skin build up a barrier against irritation and water loss.

How Panthenol is classified

Vitamins

Recommendations for using Panthenol during pregnancy and breastfeeding

Limited data suggests no known risk

Panthenol During Pregnancy

What we know about using Panthenol while pregnant or breastfeeding

Limited information available.

Two different groups of female albino rats were supplemented with the same vitamin mixture and either 100 µg or 1 mg Calcium Pantothenate after giving birth to their first litter (stock diet for all female rats during first pregnancies) and through the birth of young from their second pregnancies (gestation period not provided).2 The young born from both the first and second pregnancies were normal. No teratogenicity or fetotoxicity were reported. Provided below is a summary of DART studies that are presented in detail in Table 9. In Vitro D-Pantothenate (salt form not specified) was evaluated to determine its effect on the development of hamster embryos.66 Embryos from pregnant females were removed 10 hours after egg activation and placed in various media containing 1 µmol/l to 1 mmol/l DPantothenate or a control medium without D-Pantothenate. Embryos were incubated at 37.5 °C for 72 hours, then some were fixed and stained and cell numbers were calculated while others were implanted into female hamsters to evaluate post-implantation viability. By 72 hours, 68%-73% of cells developed into blastocysts from embryos cultured in D-Pantothenate medium compared to 37%-41% in controls; the difference was statistically significant. None of the concentrations of D-Pantothenate tested inhibited blastocyst formation. The mean number of live fetuses produced from the embryos incubated in the medium containing DPantothenate (24 fetuses/ 100 1-cell embryos) was statistically significantly greater than the mean number produced from the embryos incubated in the control medium (11 fetuses/ 100 1-cell embryos). In Vivo Rats were dosed with 0% or 0.0016% Pantothenic Acid daily in the diet for 7 weeks. 67 The researchers stated that Pantothenic Acid is necessary for the testicular and adrenal function in rats, based on the results of the study, including a statistically significant increase in testis weight (relative to body weight) and a statistically significant decrease in sperm motility, testosterone, and corticosterone plasma concentrations in untreated animals compared to treated ones. DL-Panthenyl Ethyl Ether (up to 1000 mg/kg/day) was administered by gavage to pregnant rats 1x/ day on days 6 through 19 of gestation using GLP and in accordance with OECD TG 421; the maternal and developmental NOAEL was reported to be ≥ 1000 mg/kg/day. 6 In different experiments examining the effects of orally administered Calcium Pantothenate (up to 2000 mg/kg) on pregnant rats (details on gestation were not provided) no toxicity, teratogenicity, or fetotoxicity were reported; Calcium Pantothenate was found to cross the placenta. 63,68,69

General safety info about Panthenol from CIR

No report found.

Use this, not that!

Products where you might find Panthenol

DHS Conditioning Rinse (8 fl. oz.); belif The True Cream Moisturizing Bomb; Briogeo Scalp Revival Charcoal + Coconut Oil Micro-exfoliating Scalp Scrub Shampoo; Dr. Jart+ Cicapair Tiger Grass Color Correcting Treatment SPF 30; Kosas Revealer Concealer Super Creamy + Brightening Concealer; Bumble and bumble Thickening Volume Shampoo