Peg-14

The Basics On Peg-14

What is Peg-14?

Dimethicone Copolyols belong to a class of chemicals referred to as the silicones.

What are other names for Peg-14?

PEG-14

What is Peg-14 used for?

PEGs (polyethylene glycols) are widely used in cosmetics. They are not active ingredients as such but are used as thickeners, emulsifiers, solvents, softeners, and moisture-carriers. PEGs are commonly used as cosmetic cream bases and can be found in many formulations. PEG has been shown to have anti-microbial properties1,2 which are of benefit in skincare formulations.

How Peg-14 is classified

Uncategorized

Recommendations for using Peg-14 during pregnancy and breastfeeding

Limited data suggests no known risk

 

Peg-14 During Pregnancy

What we know about using Peg-14 while pregnant or breastfeeding

Limited information available.

Ethylene Glycol and Its Ethers It is generally recognized that the PEG monomer, ethylene glycol, and certain of its monoalkyl ethers (e.g., methoxyethanol, also known as ethylene glycol monomethyl ether) are reproductive and developmental toxins. The C!R Expert Panel undertook a separate, limited review of these compounds in order to assess the possibility that PEG-derived cosmetic ingredients could present similar concerns (CIR 1996). In summary, this report concluded that the ethylene glycol monoalkyl ethers are not themselves toxic, but rather that one or more alcohol or aldehyde dehydrogenase metabolites are toxic. From the available data, the report also concluded that the toxicity of the monoalkyl ethers is inversely proportional to the length of the alkyl chain (methyl is more toxic than ethyl than propyl than butyl, etc.). In particular, because the PEG Laurate and PEG Dilaurate compounds are diesters of polyethylene glycol. and as such, are chemically different from alkyl ethers, the Panel concluded no reproductive or developmental hazards are expected to be posed by these compounds. Laureths No abnormalities were found in teratogenicity, multiple generation, fertility, and peri- and postnatal development studies in rats exposed topically to 0.4 ml/kg/day of a 6% Laureth-4 solution (Elder 1983b ). PEGs Stearate In multigenerational studies, rats fed diets containing 10% to 20% PEG-8 and -40 Stearate had decreased newborn litter survival time due to maternal neglect. Impairment of lactation efficiency as evidenced by lower weanling weights, greater mortality of nurslings, and decreased reproductive performance in the F3 generation were observed in rats fed diet containing 20% PEG-8 and -40 Stearate. No reproductive effects were noted in rats fed 5% PEGs Stearate (Elder 1983a). Polyethylene Glycol No adverse reproductive effects occurred during subchronic (90 days) and chronic (2 years) oral toxicity studies of PEG-6-32 and PEG-75. In the subchronic study, PEG-75 was tested at a dose of 0.23 g/kg/day. In the chronic study, PEG-75 was tested at doses up to 0.062 g/kg/day and, PEG-6-32 at doses up to 1.69 g/kg/day (Andersen 1993).

General safety info about Peg-14 from CIR

PEGs Dilaurate and PEGs Laurate are the diesters and monoesters, respectively, of polyethylene glycol and lauric acid used in a wide variety of cosmetic fonnulations as surfactants-emulsifying agents. PEG esters are produced by the ethoxylation of fatty acids. In general, ethoxylated fatty acids can contain 1,4-dioxane as a byproduct of ethoxylation. Traces of the reactants (fatty acid, ethylene oxide, and any catalysts) may remain in the finished product. Current concentration of use data were not available; the highest previously reported concentration was 25%. The PEGs Dilaurate and PEGs Laurate are similar to the PEGs Stearate and PEGs Distearate, and to the components (Polyethylene Glycol and Lauric Acid); all of which have been addressed in previous safety assessments. PEGs were readily absorbed through damaged skin. Fatty acids such as Lauric Acid are absorbed, digested, and transported in animals and humans. The acute oral LD50 of PEG-12 Laurate was >25 glkg in mice. In short-term feeding studies, PEGs Laorate were irritating to the gastrointestinal tract, but not necrotizing. In chronic oral toxicity studies, there was some evidence of liver damage and hyperplasia in several tissues. It is generally rec· ognized that the PEG monomer, ethylene glycol, and certain of its monoalkyl ethers are reproductive and developmental toxins. These esters and diesters are chemically different from PEG alkyl ethers and are not expected to cause adverse reproductive or developmental effects. In actual studies, PEGs Stearate, and PEGs Distearate did not cause reproductive or developmental toxicity, and were not carcinogenic. Likewise, PEGs were not carcinogenic. Although sensitization and nephrotoxicity were observed in burn patients treated with a PEG-based cream, no evidence of systemic · toxicity or sensitization was found in studies with intact skin. Be· cause of the possible presence of 1,4-dioxane reaction product and unreacted ethylene oxide residues, it was considered necessary to use appropriate procedures to remove these from PEGs Dilaurate and PEGs Laurate ingredients before blending them into cosmetic formulations. Based on the limited data on the PEGs Dilaurate and the PEGs Laurate, on the data available on the component ingre· dients, and on the data available on similar PEG fatty acid esters, Received 15 June 2000; accepted 22 August 2000. 1 Reviewed by the Cosmetic Ingredient Review Expert Panel. Rebecca S. Lanigan. former Scientific Analyst and Writer. prepared this report. Address correspondence to Director, Cosmetic Ingredient Review, II 0 I 17th Street, NW, Suite 310, Washington, DC 20036, USA. International Journal of Toxicology, 19(Suppl. 2):29-41, 2000 Copyright© 2000 Cosmetic Ingredient Review 1071-7544/00$12.00 + .00 it was concluded that PEG-2, -4, -6, -8, -12,-20, -32,-75, and -150 Dilaurate; PEG-2, -4, -8, -9, -10, -12, -14, -20, -32, -75, -150, and -200 Laurate; and PEG-2 Laurate SE are safe for use in cosmetics at concentrations up to 25%.

Use this, not that!

Products where you might find Peg-14

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