Phosphatidylcholine

The Basics On Phosphatidylcholine

What is Phosphatidylcholine?

Active ingredient in lecithin.

What are other names for Phosphatidylcholine?

PHOSPHATIDYLCHOLINE

What is Phosphatidylcholine used for?

Although Phosphatidylcholine has been used as an ingested supplement, it is also included as an ingredient in topical skin creams, and can create smoother skin, increase skin’s moisture level, condition skin and hair, support skin regeneration, and supply both choline and linoleic acid.

How Phosphatidylcholine is classified

Skin-Restoring, Skin-Replenishing, Emollients

Recommendations for using Phosphatidylcholine during pregnancy and breastfeeding

Limited data suggests no known risk

 

Phosphatidylcholine During Pregnancy

What we know about using Phosphatidylcholine while pregnant or breastfeeding

Limited information available.

Phosphatidylserine In a teratogenicity study, phosphatidylserine derived from bovine cerebral cortex was administered by gavage to pregnant Sprague-Dawley rats (CD strain; number not stated) at doses of 0, 10, 100, and 200 mg/kg/day on days 6 through 18 of gestation.58 The animals were killed on day 20 of gestation, and litters were examined for skeletal and visceral abnormalities. At terminal necropsy, there were no treatment-related gross changes. Additionally, the following litter values were not affected by treatment with phosphatidylserine: litter size, post-implantation loss, litter and mean fetal weights, and embryonic and fetal development. Phosphatidylserine derived from bovine cerebral cortex was also administered by gavage to pregnant New Zealand White rabbits (number not stated) at doses of 0, 50, 150, and 450 mg/kg/day on days 6 through 18 of gestation.58 On gestation day 29, the animals were killed and litters subjected to gross examination. Fetuses were examined externally and internally for evidence of visceral and skeletal malformations. There was no evidence of systemic effect, and neither pregnancy nor mortality was affected by treatment. At the highest dose, mean fetal weights were slightly lower when compared to control values, but the difference was not statistically significant. Additionally, there were no treatment-related effects on embryonic and fetal development. Lysophosphatidic Acid Lysophosphatidic acid and sphingosine 1-phosphate are both lysophospholipids. 65 Because lysophosphatidic acid promotes prostaglandin synthesis, mediators in the lysophosphatidic acid pathway may also play a significant role in implantation and parturition. Sphingosine 1-phosphate signaling is thought to be essential in vascular formation within the uteroplacental unit and in fetomaternal immunologic interactions. Derangements in either one of these lysophospholipid signaling pathways could result in pregnancy complications that may include implantation failure, preeclampsia, and preterm labor. Immature germinal vesicle stage oocytes from 5- to 6-week-old female BDF-1 mice were incubated for 17–18 h in in vitro maturation (IVM) medium containing 0, 1, 10 or 30 µM lysophosphatidic acid and then either fertilized in vitro with epididymal sperm or assessed for spindle morphology or mitochondrial membrane potential. 66 Chromosomal aneuploidy in the resultant blastocysts and the production of normal pups were not assessed. The fertilized embryos were grown in vitro to assess blastocyst-formation rates, differential cell counts and apoptosis. The supplementation of IVM with 30 µM lysophosphatidic acid enhanced the maturation and developmental competence of mouse oocytes. Rates of maturation, fertilization and blastocyst formation and hatching were significantly higher in the 30 µM lysophosphatidic acidsupplemented group (94.3%, 96.3%, 79.1 and 51.3%, respectively) than in the unsupplemented control (0 mM) group (80.5%, 87.5%, 61.3% and 37.8%, respectively), and more comparable to that of the in vivo matured oocytes (100%, 96.5%, 95.3% and 92.9%, respectively). Lysophosphatidic acid did not adversely affect mitochondrial activity, spindle integrity, or blastocyst cell number. The results of this study imply that the supplementation of IVM medium with 30 µM lysophosphatidic acid may enhance the developmental competence of mouse oocytes without affecting apoptosis, spindle normalcy or mitochondrial integrity.

General safety info about Phosphatidylcholine from CIR

No report found.

Use this, not that!

Products where you might find Phosphatidylcholine

N/A