Polyaminopropyl Biguanide

The Basics On Polyaminopropyl Biguanide

What is Polyaminopropyl Biguanide?

Synthetic polymer that functions as a preservative.

What are other names for Polyaminopropyl Biguanide?

IMIDODICARBONIMIDIC DIAMIDE, N-(3-AMINOPROPYL)- HOMOPOLYMER, N-(3-AMINOPROPYL)- HOMOPOLYMER IMIDODICARBONIMIDIC DIAMIDE, and POLYAMINOPROPYL BIGUANIDE

What is Polyaminopropyl Biguanide used for?

Polyaminopropyl biguanide (PAPB) is a disinfectant and a preservative used for disinfection on skin and in cleaning solutions for contact lenses. It is also an ingredient in many deodorant bodysprays.

How Polyaminopropyl Biguanide is classified

Preservatives

Recommendations for using Polyaminopropyl Biguanide during pregnancy and breastfeeding

Limited data suggests no known risk

 

Polyaminopropyl Biguanide During Pregnancy

What we know about using Polyaminopropyl Biguanide while pregnant or breastfeeding

Limited information available.

The developmental and reproductive toxicity studies summarized below are presented in Table 10. An NOAEL of 10 mg/kg/day for developmental toxicity was reported in an oral dosing (by gavage on gestation days 6 through 15) study on 20% aqueous Polyaminopropyl Biguanide involving mice.18,28 In oral reproductive and developmental toxicity studies on 20% aqueous Polyaminopropyl Biguanide in rats, NOAECs of 1000 ppm (after feeding in diet on gestation days 1 through 20)18 and 1300 ppm (after feeding in diet during a 9-day pre-mating period and until the 3rd generation)18,21 have been reported . An NOAEL of 2000 ppm for reproductive and development effects was reported in a study in which rats were fed (through 2 successive generations) with 20.2% aqueous Polyaminopropyl Biguanide at dietary concentrations up to 2000 ppm.18 Polyaminopropyl Biguanide has been classified as embryotoxic at a dosage rate of 100 mg/kg/day (rats; protocol not stated).29 An NOAEL of 40 mg/kg/day for developmental toxicity has been reported in an oral dosing (20.2% aqueous Polyaminopropyl Biguanide by gavage on gestation days 8 through 20) study involving rabbits.18 Polyaminopropyl Biguanide (0.04% in polyethylene glycol) has been classified as embryotoxic in rabbits at an oral dosage rate of 32 mg/kg/day (animal strain and dosing protocol not stated). 29 Polyaminopropyl Biguanide (concentration not stated) has been classified as teratogenic in rats at an intraperitoneal dosage rate of 10 mg/kg/day (dosing protocol not stated).29 In an inhalation study on 20% aqueous Polyaminopropyl Biguanide, degeneration of seminiferous tubules in the testis of 1 male rat was observed after exposure to 0.25 mg/m3 (6 h/day, 5 days/week for 3 weeks), but this was not observed in any other group, including the group exposed to the highest concentration (26 mg/m3 ).18

General safety info about Polyaminopropyl Biguanide from CIR

The Cosmetic Ingredient Review (CIR) Expert Panel reviewed the safety of Polyaminopropyl Biguanide (polyhexamethylene biguanide hydrochloride), which functions as a preservative in cosmetic products. The Panel reviewed relevant data relating to the safety of this ingredient and concluded that Polyaminopropyl Biguanide is safe in cosmetics in the present practices of use and concentration described in the safety assessment, when formulated to be nonirritating and non-sensitizing, which may be based on a quantitative risk assessment (QRA) or other accepted methodologies. The Panel also concluded that the data are insufficient to determine the safety of Polyaminopropyl Biguanide in products that may be inhaled.

Use this, not that!

Products where you might find Polyaminopropyl Biguanide

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