Polyglyceryl-3 Stearate

The Basics On Polyglyceryl-3 Stearate

What is Polyglyceryl-3 Stearate?

Polyglyceryl-3 stearate is the ester of the fatty acid stearic acid and polyglycerin-3, which is a polymer of glycerin that contains three units.

What are other names for Polyglyceryl-3 Stearate?

MONOESTER WITH 3,3′-[(2-HYDROXY-1,3-PROPANEDIYL)BIS(OXY)]BIS[1,2-PROPANEDIOL- OCTADECANOIC ACID, MONOESTER WITH TRI-1,2,3-PROPANETRIOL DIETHER OCTADECANOIC ACID, MONOESTER WITH TRIGLYCEROL OCTADECANOIC ACID, OCTADECANOIC ACID, MONOESTER WITH 3,3′-[(2-HYDROXY-1,3-PROPANEDIYL)BIS(OXY)]BIS[1,2-PROPANEDIOL-, OCTADECANOIC ACID, MONOESTER WITH TRI-1,2,3-PROPANETRIOL DIETHER, OCTADECANOIC ACID, MONOESTER WITH TRIGLYCEROL, POLYGLYCERYL-3 STEARATE, and TRIGLYCERYL MONOSTEARATE

What is Polyglyceryl-3 Stearate used for?

This synthetic ingredient is used in cosmetics to impart an emollient feel that conditions skin, as an emulsifier to keep unlike ingredients (think oil and water) blended, and, in greater amounts as a surfactant. It is considered safe and non-sensitizing as used in cosmetics.

How Polyglyceryl-3 Stearate is classified

Emollients, Emulsifiers

Recommendations for using Polyglyceryl-3 Stearate during pregnancy and breastfeeding

Limited data suggests no known risk

 

Polyglyceryl-3 Stearate During Pregnancy

What we know about using Polyglyceryl-3 Stearate while pregnant or breastfeeding

Limited information available.

Oral Polyglycerol Esters – general A test group of 22 rats were fed a diet containing 1.5% polyglycerol for 3 generations.27 A group of 28 rats were used as controls. The animals were kept for over 1 year without significant variation in fertility or reproductive performance. Gross and microscopic examination of the third generation revealed no consistent abnormality related to the test substance. No details were provided. Polyglyceryl-3 Diisostearate A combined repeated dose oral toxicity study with a reproduction/developmental toxicity screening test (OECD Guideline 422) was conducted in Wistar rats. 39 The animals were dosed once daily by gavage with 0, 100, 300, or 1000 mg/kg bw/day 1,2,3-propanetriol, homopolymer, diisooctadecanoate (n not defined; but this ingredient is most likely Polyglyceryl-3 Diisostearate) in corn oil. Initially, the groups consisted of 12 males and 12 females. However, because a disturbance of the light/dark cycle was believed to cause a reduction in mating rate of the females of the first delivery, additional male and female rats were added in a second delivery for breeding in order to meet guideline requirements concerning number of gravid females per group. The additional animals were used in the whole study as the animals from the first delivery, with the exception that the males went to necropsy on day 24 after mating, and not on day 16 of mating as the males of the first delivery. Therefore, Polyglyceryl-3 Diisostearate was administered to male rats for up to 28 days (first delivery) and up to 41 days (second delivery) and to female rats for 14 days prior to mating, through the mating and gestation periods, and until the F1 generation reached day 4 post-partum. Because an impact cause by the light/dark cycle disturbance could not be excluded (i.e., a prolonged duration of gestation and an increased post-implantation loss in the high dose), the study was repeated with a third delivery with control and high-dose groups under proper light conditions. The test article was administered to 12 male rats/group for 33 days and to 12 female rats/group for 14 days prior to mating, through the mating and gestation, and until day 4 post-partum. Five males and 5 females/group killed at the end of the study were selected for hematology and clinical chemistry examinations, and some additional organs were weighed. The NOEL and NOAEL for systemic effects were ‚â•300 mg/kg bw/day and ‚â•1000 mg/kg bw/day 1,2,3-propanetriol, homopolymer, diisooctadecanoate, respectively, in both males and females. No adverse effects on body weights and body weight gains, feed consumption, hematology, clinical chemistry, neurobehavior, or gross or microscopic lesions were observed. Statistically significantly increases in absolute and relative liver and kidney weights in males and females of the 1000 mg/kg bw/day, were not considered adverse effects because there was no evidence for an impairment of organ function by clinical pathology and histopathology. Additionally, increases in the absolute and relative heart weights in high-dose females were without histopathological correlation and considered to be incidental.

General safety info about Polyglyceryl-3 Stearate from CIR

No report found.

Use this, not that!

Products where you might find Polyglyceryl-3 Stearate

Anastasia Beverly Hills Lash Brag Volumizing Mascara;Anastasia Beverly Hills Lash Brag Volumizing Mascara Mini