The Basics On Ppg-26-Buteth-26

What is Ppg-26-Buteth-26?

Part of the PPG Buteth ingredient group.

What are other names for Ppg-26-Buteth-26?

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What is Ppg-26-Buteth-26 used for?

PPG stands for polypropylene glycol, and this ingredient combines PPG with an ether of a fatty alcohol known as buty alcohol. It has multiple functions in cosmetic products, ranging from hair conditioning agent to surfactant (cleansing agent), and emulsifier.

How Ppg-26-Buteth-26 is classified

Emulsifiers, Cleansing Agents

Recommendations for using Ppg-26-Buteth-26 during pregnancy and breastfeeding

Limited data suggests no known risk

 

Ppg-26-Buteth-26 During Pregnancy

What we know about using Ppg-26-Buteth-26 while pregnant or breastfeeding

Limited information available.

PPG-2 Butyl Ether when dermally applied was nontoxic to pregnant rats and was non-teratogenic at doses up to 1.0 ml/kg/ day.1 The developmental and reproductive toxicity (DART) studies summarized below are described in Table 11. Appropriate read-across materials were identified for dermal and oral DART testing, and those data are included in this table. Dermal application of PPG-2 Butyl Ether to rats during days 6-16 of gestation produced local skin reactions, but not reproductive or teratogenic effects (NOEL > 1 ml/kg).17 Dermally applied Propylene Glycol Butyl Ether was not embryotoxic or teratogenic to rats (≤1.0 ml/kg bw/day applied on days 6-16 of gestation) 9,11,17 or rabbits (≤100 mg/kg bw/day applied on days 7-18 of gestation). 9,10,17 Dermal application of up to 910 mg/kg bw/day 1-(2-butoxy-1-methylethoxy)-propan-2-ol was not embryotoxic, fetotoxic, or teratogenic in rats. 9-11 No test-article related adverse developmental or reproductive effects were observed in rats dosed by gavage (days 7-16 of gestation) with up to 1000 mg/kg Buteth-3. 31 No effects on reproduction were observed in rats dosed orally prior to and during mating with up to 500 mg/kg bw/day poly[oxy(methyl-1,2-ethanediyl)],α-butyl-ω-hydroxy11 or up to 1000 mg/kg bw/day 1-(2-butoxy-1-methylethoxy)-propan-2-ol.10

General safety info about Ppg-26-Buteth-26 from CIR

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 46 butyl polyoxyalkylene ethers that share a common structural motif, namely a butyl chain (4 carbon alkyl chain) bound to a polyoxyalkylene (PPG, PEG, or both); 23 of these ethers were previously reviewed by the Panel, and 23 are reviewed for the first time. Most of the butyl polyoxyalkylene ethers have several functions in cosmetics, but the most common functions include hair conditioning agent and skin conditioning agent, and many function as solvents. Upon review of new data, including frequency and concentration of use, and data from previous CIR reports and on read-across analogs, the Panel concluded that these ingredients are safe in the present practices of use and concentration in cosmetics when formulated to be non-irritating.

Use this, not that!

Products where you might find Ppg-26-Buteth-26

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List of References

General sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/

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Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.

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