Propanediol

The Basics On Propanediol

What is Propanediol?

A glycol that can enhance ingredient absorption.

What are other names for Propanediol?

1,3-DIHYDROXYPROPANE, 1,3-PROPYLENE GLYCOL, 1,3PROPANEDIOL, PROPANE-1,3-DIOL, and PROPANEDIOL

What is Propanediol used for?

Functions. In cosmetics and personal care products, propanediol functions as an emollient, humectant, and solvent. As an emollient, propanediol has the ability to soften and soothe the skin. Upon application, propanediol forms an occlusive film on the surface of skin that aids in preventing water loss.

How Propanediol is classified

Uncategorized

Recommendations for using Propanediol during pregnancy and breastfeeding

Limited data suggests no known risk

 

Propanediol During Pregnancy

What we know about using Propanediol while pregnant or breastfeeding

Limited information available.

Oral Developmental and reproductive toxicity studies were conducted in animals that were orally exposed to Propanediol, 1,4-Butanediol, Hexanediol, Methylpropanediol , or Butyl Ethyl Propanediol. In rat studies evaluating Propanediol at dose rates up to 1000 mg/kg/day,spermatogenic endpoints were unaffected (90-day exposure duration)88and no maternal (dosing on days 6-15 of gestation) or fetal toxic effects were observed (maternal and fetal NOAEL 1000 mg/kg/day).12In a mouse study evaluating 1,4-Butanediol at up to 600 mg/kg/day(dosing on days 6-15 of gestation),a maternal and developmental NOAEL of 100 mg/kg/day and a LOAEL of 300 mg/kg/day werereported;maternal central nervous system intoxication (300-600 mg/kg/day) and maternal and fetal body weight reduction (maternal 300-600 mg/kg/day) were observed.91For maleand female rats dosed with up to 800 mg/kg/day 1,4-Butanediol (14 days prior to mating and for females through day 3 of lactation),the following were reported: developmental NOEL of 400 mg/kg/day(pup weight slightly but statistically significantly decreased on lactation day 4 at 800 mg/kg/day, secondary to maternal reduction in body weight), parental transient hyperactivity (200 and 400 mg/kg/day) and reversible parental hypoactivity (‚â• 400 mg/kg/day), but no parental reproductive parameters were changed by treatment.13,22A maternal and developmental NOAEL of 1000 mg/kg/day was reported in animal studies onHexanediol (ratsdosed on days 6-19 of gestation)15and for Methylpropanediol (rats dosed on days 0-20 of gestation; rabbits on days 0-29).2,32In a rat study evaluating Butyl Ethyl Propanediol (up to 1000 mg/kg/day on days 6-19 of gestation),a maternal NOAEL of 150 mg/kg/day (reduced activity, staggering, limb dragging, slow respiration, and reduced food consumption/body weight at 1000 mg/kg dose) and a developmental NOAEL of 1000 mg/kg/day were reported.

General safety info about Propanediol from CIR

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 10 alkane diolingredients as used in cosmetics. The alkane diolsare structurally relatedto each other as small diols, and mostare reported to function in cosmetics assolvents. The Panel reviewed the relevant data for these ingredients, andconcludedthat sevenalkane diols are safe in cosmetics in the present practices of use and concentration described in this safety assessment, but that the available data are insufficient to make a determination of safety forthreeingredients, namely 1,4-Butanediol, 2,3-Butanediol, and Octanediol.

Use this, not that!

Products where you might find Propanediol

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