Propionic Acid

The Basics On Propionic Acid

What is Propionic Acid?

What are other names for Propionic Acid?

CARBOXYETHANE, METHYLACETIC ACID, PROPANOIC ACID, and PROPIONIC ACID

What is Propionic Acid used for?

How Propionic Acid is classified

Recommendations for using Propionic Acid during pregnancy and breastfeeding

Limited data suggests no known risk

 

Propionic Acid During Pregnancy

What we know about using Propionic Acid while pregnant or breastfeeding

Limited information available.

Although there is no information available in the literature on the reproductive and developmental toxicity of sodium lauriminodipropionate, an SAR assessment was conducted which considered the potential metabolites of this ingredient (see Figure 1).8 Sodium lauriminodipropionate is likely to be metabolized by glucuronidation and/or N-dealkylation. The glucuronide product for sodium lauriminodipropionate has not been assessed for reproductive or developmental toxicity; however, glucuronides in general have not been classified as developmental or reproductive hazards. Among the products of N-dealkylation, straight-chain fatty acids, such as lauric acid, have been evaluated for reproductive and developmental hazards, and no adverse effects have been reported.8,14 The CIR Expert Panel has reviewed several straight-chain fatty acids, including lauric acid and related ingredients, including plant-derived fatty acid oils, and has found these ingredients to be safe for use in cosmetic products.9-11 Although the possible N-dealkylation product laurylamine has not been tested for reproductive toxicity, a similar compound, oleylamine, has been assessed and found not to affect the development in rats and rabbits, even at maternally toxic oral doses.8 The developmental no-observed-adverse effect-level (NOAEL) was 80 mg/kg/d for rats and 30 mg/kg/d for rabbits in these studies. A mixture of tallow alkyl amines, another possible N-dealkylation product, did produce a decrease in offspring weight and a decrease in fertility at severely toxic levels that can be attributed to being secondary to the toxicity. In a previous assessment by the CIR Expert Panel, malonic acid, a potential product of N-dealkylation, was evaluated for developmental toxicity in rats assessed and determined to be safe for use in cosmetic products.15 At concentration of 9% or 12% malonate in feed (approximate dosage for 9% malonate was 4.5 g/kg/d), low toxicity was observed in dams and fetuses.16 A few malformations were reported for 4.5 g/kg/d, but these incidences were within historical control ranges, and this dose was considered the NOAEL for developmental toxicity.

General safety info about Propionic Acid from CIR

The Cosmetic Ingredient Review Expert Panel assessed the safety of lauriminodipropionic acid, sodium lauriminodipropionate, and disodium lauriminodipropionate as used in cosmetics. These ingredients function in cosmetics as hair-conditioning agents and surfactant-cleansing agents. The Panel reviewed relevant animal and human data related to the safety of these ingredients in cosmetics. The Panel concluded that lauriminodipropionic acid, sodium lauriminodipropionate, and disodium lauriminodipropionate are safe as cosmetic ingredients in the present practices of use and concentration.

Use this, not that!

Products where you might find Propionic Acid

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