The Basics On Red 33

What is Red 33?

What are other names for Red 33?

2,7-NAPHTHALENEDISULFONI C ACID, 5-AMINO-4-HYDROXY-3-(PHENYLAZO)-, DISODIUM SALT, 2,7NAPHTHALENEDISULFONIC ACID, 5AMINO4HYDROXY3(PHENYLAZO), DISODIUM SALT, 5-AMINO-4-HYDROXY-3-(PHENYLAZO)- DISODIUM SALT 2,7-NAPHTHALENEDISULFONI C ACID, CI 17200, D&C RED 33, D&C RED NO. 33, D&C RED NO. 33 (CI 17200), DISODIUM 5-AMINO-4-HYDROXY-3-(PHENYLAZO)NAPHTHALENE-2,7-DISULPHONATE, DISODIUM SALT 2,7-NAPHTHALENEDISULFONI C ACID, 5-AMINO-4-HYDROXY-3-(PHENYLAZO)-, FD&C RED 33, and RED 33

What is Red 33 used for?

Red 33 (D&C Red No. 33) and Red 33 are synthetic colorants. In cosmetics and personal care products, Red 33 and Red 33 Lake are used in the formulation of a wide variety of product types, including makeup and lipstick. Red 33 is used to impart a red color to cosmetics and personal care products.

How Red 33 is classified

Coloring Agents/Pigments

Recommendations for using Red 33 during pregnancy and breastfeeding

Limited data suggests no known risk

 

Red 33 During Pregnancy

What we know about using Red 33 while pregnant or breastfeeding

Limited information available.

No reproductive/developmentl toxicity reported from animal testing. Source: European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22. The Food and Drug Research Labs (1966) tested Dimethicone-containing fluids in oral studies to investigate possible atrophic changes in rat seminal vesicles. The test material was administered directly into the stomach of 10 male Sprague-Dawley rats at a dose of 3.3 ml/kg/day for 6 days. A control group received saline. Feed and water were available ad libitum. Rats were killed at the end of dosing and necropsy was performed. Final body weight and the weight of the seminal vesicles were measured. A Dimethicone sample (TX-158F) produced a significant reduction in the average seminal vesicle to body weight ratio but not in absolute organ weight. Two other Dimethicone samples had no adverse effect. Atlas Chemical Industries (1970) reported a study in which a medical grade antifoam compound (93% Dimethicone) was given orally to pregnant Wistar rats on gestational days (GDs) 6 to 15 at doses of 0.38, 1.20, and 3.80 g/kg/day. The highest dose was selected to represent 70 times the recommended clinical dose for the treatment of intestinal gas and 1000 times that recommended to treat peptic ulcers. A control group received tap water. Rats were examined by laparotomy on GD 20 at which time fetuses were removed from the uterus. Dams were killed and the ovaries were examined for corpora lutea. The authors concluded that Dimethicone at any dose did not induce significant differences in fetal viability at laparotomy, resorptions, average weight, and gross external, soft tissue, and skeletal anomalies. Siddiqui (1994) fed an antifoam compound (food-grade Dimethicone) to time-mated New Zealand white rabbits at concentrations of 0%, 0.5%, 1.0%, and 2.5% on GDs 6 to 19. Females were observed daily for clinical signs of toxicity. On gravid day 29, confirmed-pregnant females (20 to 22 per group) were evaluated for gestational outcome. Each live fetus was examined for external, visceral, and skeletal malformations. No overt signs of toxicity in the dams, and no statistically significant differences in feed consumption were observed between treated and control rabbits. No adverse effects were noted in mean maternal body weight or liver weight. The incidence of resorptions among the total fetal population was not altered by feeding the antifoam compound. Male and female pup weights were not affected by the maternal treatment. No significant treatment related adverse effects in the incidence of external, visceral, or skeletal abnormalities were observed.

General safety info about Red 33 from CIR

No report found.

Use this, not that!

Products where you might find Red 33

Bioderma Sensibio AR Cream (1.33 fl. oz.); PAT McGRATH LABS Sublime Perfection Foundation, SEPHORA COLLECTION Colorful Shadow & Liner, Givenchy Le Rouge Deep Velvet Matte Lipstick, HUDA BEAUTY Kayali Miniature Discovery Set, Marc Jacobs Fragrances Daisy Eau So Fresh

 

 

 

List of References

General sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/

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Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.

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