Sodium Bisulfite

The Basics On Sodium Bisulfite

What is Sodium Bisulfite?

Used in acid-type permanent waves to alter the shape of hair.

What are other names for Sodium Bisulfite?

MONOSODIUM SALT SULFUROUS ACID, SODIUM ACID SULFITE, SODIUM BISULFITE, SODIUM HYDROGENSULPHITE, and SULFUROUS ACID, MONOSODIUM SALT

What is Sodium Bisulfite used for?

Sodium Sulfite, Potassium Sulfite, Sodium Bisulfite and Sodium Metabisulfite function as antioxidants preventing or slowing deterioration of cosmetics and personal care products caused by chemical reactions with oxygen.

How Sodium Bisulfite is classified

Sensitizing

Recommendations for using Sodium Bisulfite during pregnancy and breastfeeding

Limited data suggests no known risk

 

Sodium Bisulfite During Pregnancy

What we know about using Sodium Bisulfite while pregnant or breastfeeding

Limited information available.

An unscheduled DNA synthesis assay was performed using groups of 4 male rats of the Wistar Hanlbm:WIST (SPF) strain.7 Sodium Bisulfite (formulated in citrate/NaOH buffer at pH 5) was administered orally at doses of 625 and 1250 mg/kg (dose Distributed for Comment Only — Do Not Cite or Quote volume = 10 ml/kg). At 2 h and 16 h post-dosing, the animals were killed by liver perfusion. Primary hepatocytes (obtained from 3 animals per group) were then exposed to methyl-[3 H]-thymidine (3 HTdR) for 4 h to show its incorporation if unscheduled DNA synthesis occurs. N,N’-Dimethylhydrazine dihydrochloride (40 mg/kg) and 2-acetylamino-fluorene (100 mg/kg) served as positive controls. Hepatocytes were not substantially affected after treatment. No dose level of the test substance revealed unscheduled DNA synthesis induction in the hepatocytes of treated animals when compared to the current vehicle controls. The net gain values obtained after treatment with the test item were consistently negative. In addition, no substantial shift to higher values was obtained in the percentage distribution of nuclear grain counts. From the results obtained in this study, it was concluded that sodium bisulfite failed to show any evidence of mutagenic potential in this in vivo test for unscheduled DNA synthesis when administered orally at pH 5.0. A micronucleus test was performed using groups of 12 mice (6 males and 6 females per group) of the NMRI strain.7 Sodium Bisulfite (formulated in citrate/sodium hydroxide buffer at pH 5) was administered intraperitoneally at doses of 75 mg/kg, 150 mg/kg, and 300 mg/kg (dose volume = 15 ml/kg). Bone marrow from the femur was extracted 24 h and 48 h after application. For each animal at least 2000 polychromatic erythrocytes (PCE) obtained from the bone marrow were examined. The frequency of micronuclei was calculated for each animal and dose group. Cyclophosphamide (40 mg/kg) and the vehicle (citrate/sodium hydroxide buffer) served as positive and negative controls, respectively. The treated mice exhibited normochromatic/polychromatic erythrocytes ratios that were higher than in negative controls, demonstrating the bioavailability of the test substance in the bone marrow. The number of micronucleated PCE was similar to those seen in controls. From the results obtained in this study, it was concluded that Sodium Bisulfite failed to show any evidence of mutagenic potential in this in vivo test for chromosomal alterations when administered intraperitoneally at pH 5.0.

General safety info about Sodium Bisulfite from CIR

No report found.

Use this, not that!

Products where you might find Sodium Bisulfite

Drunk Elephant B-Hydra Intensive Hydration Serum; Drunk Elephant Lala Retro Whipped Moisturizer with Ceramides; The Ordinary Natural Moisturizing Factors + HA