Sodium Metabisulfite

The Basics On Sodium Metabisulfite

What is Sodium Metabisulfite?

Reducing agent that alters the structure of hair.

What are other names for Sodium Metabisulfite?

DISODIUM DISULPHITE, DISODIUM SALT DISULFUROUS ACID, DISODIUM SALT PYROSULFUROUS ACID, DISULFUROUS ACID, DISODIUM SALT, PYROSULFUROUS ACID, DISODIUM SALT, SODIUM METABISULFITE, and SODIUM PYROSULFITE

What is Sodium Metabisulfite used for?

In cosmetics and personal care products, sodium metabisulfite functions as an antioxidant preservative and a hair-waving/straightening agent. As an antioxidant preservative, sodium metabisulfite works by protecting the other ingredients in a formulation from oxidation, which is the loss of electrons.

How Sodium Metabisulfite is classified

Antioxidants, Preservatives, Sensitizing

Recommendations for using Sodium Metabisulfite during pregnancy and breastfeeding

Limited data suggests no known risk

 

Sodium Metabisulfite During Pregnancy

What we know about using Sodium Metabisulfite while pregnant or breastfeeding

Limited information available.

Sodium Metabisulfite Sodium Metabisulfite was not teratogenic for mice, rats, hamsters, or rabbits at doses of 160, 110, 120, and 123 mg/kg, respectively. 1 It was also negative in sulfite oxidase-deficient rats when tested at doses up to 3.5 mmol/kg. In a study utilizing sulfite oxidase-deficient virgin female Wistar rats, the endogenous and exogenous toxicity of sulfites was examined.1 The sulfite oxidase deficiency was achieved through the addition of tungsten and reduced molybdenum. Four control groups, all having normal hepatic sulfite oxidase activity, were fed normal protein diets and two groups were provided with normal tap water. Two of the control groups with normal sulfite oxidase activities received no drinking water supplementation. The other two control groups received tungsten, molybdenum, and sodium sulfate (12.5 mM) in their drinking water. The three treatment groups, consisting of sulfite oxidase-deficient animals, received either tungsten and sodium sulfate (25 mM), or tungsten and sodium sulfate (50 mM). The mean steady-state sulfite oxidase activity of all treatment groups was about 1 to 2% of normal adult activities. At week 7, all rats were mated with normal males. All rats, including nonpregnant rats, were killed on day 21 of gestation. Toxicity due to decreased feed consumption, reactions with feed constituents of the diet, and irritation of the gut were observed in this study. These effects and anemia were produced by the large concentrations of sulfite in the diet or gut; systemic sulfite does not appear to be related to any toxicity seen in this study. Sodium Metabisulfite was added to the drinking water (375 and 750 ppm as sulfur dioxide) of three generations of rats for 2.5 years. 1 Generation I consisted of three groups: 13 females in each group, with group I having 5 males and group II having 6 males. The control groups of generation II were produced from the matings of control groups of generation I. Likewise, the sulfite drinking water groups of generation II were produced from matings of control groups of generation I. Generation II was derived similarly from generation II. No significant difference was reported in the number of offspring of either generation I or II, and the proportion surviving to the end of lactation did not differ. Neither weight nor the percentage of weight contributed by various organs was affected. Microscopic examination of various tissues was completed ten months after treatment began. No abnormalities of the spleen, adrenal glands, stomach, ileum, colon, gastrocnemius muscle, sciatic nerve, uteri, testes, and seminal vesicles were observed. Thirty-seven percent of 54 animals had tumors. Incidences were greater among groups of females but unaffected by the addition of sulfite to the water. In a three-generation study, groups of 40 rats (20 per sex) received 0.125, 0.25, 0.5, 1, or 2% Sodium Metabisulfite administered in a thiamine-rich diet beginning shortly after weaning. 1 Rats of the F0 generation were mated during weeks 21 and 34 to produce F1a and F1b generations, respectively. Ten males and 10 females of the F1a generation were selected for further mating. F0 rats and the selected F1a were fed the same diet for 104 weeks. The selected F1a rats were mated during weeks 12 and 30; pups of the F2a litters were selected for mating. The F3 litters were discarded; their dams were fed the same diet for 30 weeks. Five males and five females of the F0 generation were killed at week 52 for interim observations on organ weights and pathological changes. Relative kidney weight was increased in F2 females of the 2% group, but was not accompanied by functional or histopathologic renal changes. At doses of ‚â• 1% Sodium Metabisulfite (300 and 600 mg sulfur dioxide/kg/day), inflammatory and hyperplastic changes in the stomach and occult blood in the feces were observed in rats of all three generations. Slight changes in the stomach of F2 rats of the 0.5% group were observed. The number of F2a pups was significantly reduced in groups fed ‚â• 0.5% Sodium Metabisulfite. The no-effect level was 0.25% Sodium Metabisulfite (or 0.215% accounting for the loss of sulfite). The corrected value corresponded to 72 mg sulfur dioxide/kg/day. A study similar to the preceding 3-generation study was conducted using groups of 40 guinea pigs (20 of each sex) fed 0.06, 0.16, 0.35, 0.83, and 1.72% Sodium Metabisulfite. 1 Diets were supplemented with thiamine. After 15 weeks, 14 males and 14 females from each group were killed; the remaining guinea pigs were kept on their respective diets for an additional 33 weeks. No adverse effects on health or hematological parameters were observed. In contrast to the rat study, occult blood was not detected in the feces. Guinea pigs of the 0.83% and 1.72% groups had decreased growth and decreased feed conversion that were considered due to reduced consumption of the less palatable diets. Organ-to-body weight ratios of the liver, kidneys, hear, and spleen were increased in the 0.83% and 1.72% dose groups; the increase in heart and spleen weights was attributed to the lowered body weights. Inflammatory and hyperplastic changes of the gastric mucosa were observed in several guinea pigs of the 0.83% and 1.72% groups. A black pigmentation of the cecal mucosa that resembled pseudomelanosis coli was also observed, but was not considered toxicologically significant. The no-effect level was 0.35% Sodium Metabisulfite in the diet for 48 weeks. The effects of Sodium Metabisulfite on testicular function and morphometric values of the epididymis were evaluated using groups of 8 adult male Wistar rats.26 The experimental groups received Sodium Metabisulfite (in distilled water) by gavage at the following doses for 28 consecutive days: 10, 100, and 260 mg/kg. An equal volume of normal saline was Distributed for Comment Only – Do Not Cite or Quote administered to the control group via gavage. The rats were anaesthetized after 28 days and the left testis (with the head of epididymis) was excised. The epididymal sperm were analyzed for motility, morphology, and the number of sperm. Study results showed that normal morphology, count, and motility of sperm, and testosterone level, were decreased in all of the groups dosed with Sodium Metabisulfite. The serum level of testosterone (ng/ml) in the 260 mg/kg dose group decreased significantly (p = 0.001) in comparison with the control group. When compared to the control group, dosing with Sodium Metabisulfite resulted in a statistically significant lower total number of spermatogonia, primary spermatocyte, spermatids, and Leydig cells. The treated groups also showed a significant decrease in the mean diameter of the epididymal tubules and mean height of the epithelial cell when compared to the controls. The data also revealed that normal morphology sperm percentage was reduced significantly (p < 0.001) in the 100 mg/kg and 260 mg/kg dose groups. The immotile sperm were significantly increased (p < 0.001) in the 260 mg/kg dose group in comparison with the control group. In their conclusion, the authors suggested that Sodium Metabisulfite decreases sperm production and has the potential to affect fertility adversely in male rats.26 Three groups of 7 Sprague-Dawley rats were dosed by gavage with 0.7 mg/kg, 7 mg/kg, or 70 mg/kgSodium Metabisulfite daily for a period of 7 weeks.27 The control group was dosed (by gavage) with distilled water. No change was identified in the parameters of spermatozoa in the 0.7 mg/kg/day group. However, when compared to the control group, a significant (p < 0.05) decrease was observed in the number of spermatozoa, percentage of normal morphology spermatozoa, and percentage of motile spermatozoa in the animals of the 2 higher dose groups (7 mg/kg/day and 70 mg/kg/day). The results also revealed a negligible change in the testicle volumes in these 2 groups. The seminiferous tubule volumes were reduced by 25% and 26% in rats exposed to 7 mg/kg/day and 70 mg/kg/day, respectively, when compared to the control group (p < 0.01). The results also indicated that the total volume of the seminiferous tubule germinal epithelium decreased by values of 28% and 36% in the rats that received 7 mg/kg/day and 70 mg/kg/day, respectively, when compared to the control group (p < 0.01).

General safety info about Sodium Metabisulfite from CIR

No report found.

Use this, not that!

Products where you might find Sodium Metabisulfite

Drunk Elephant B-Hydra Intensive Hydration Serum; Drunk Elephant Lala Retro Whipped Moisturizer with Ceramides; The Ordinary Natural Moisturizing Factors + HA