Sodium Myreth Sulfate

The Basics On Sodium Myreth Sulfate

What is Sodium Myreth Sulfate?

Detergent cleansing agent similar to sodium laureth sulfate or ammonium laureth sulfate.

What are other names for Sodium Myreth Sulfate?

ETHANOL, 2[2[2(TETRADECYLOXY)ETHOXY]ETHOXY], HYDROGEN SULFATE, SODIUM SALT, PEG-(1-4) MYRISTYL ETHER SULFATE, SODIUM SALT, POLYETHYLENE GLYCOL (1-4) MYRISTYL ETHER SULFATE, SODIUM SALT, SODIUM 2-[2-[2-(TETRADECYLOXY)ETHOXY]ETHOXY]ETHYL SULPHATE, SODIUM MYRETH SULFATE, SODIUM MYRISTYL ETHER SULFATE, SODIUM POLYOXYETHYLENE MYRISTYL ETHER S ULFATE SOLUTION, SODIUM POLYOXYETHYLENE MYRISTYL ETHER SULFATE, SODIUM SALT PEG-(1-4) MYRISTYL ETHER SULFATE, and SODIUM SALT POLYETHYLENE GLYCOL (1-4) MYRISTYL ETHER SULFATE

What is Sodium Myreth Sulfate used for?

How Sodium Myreth Sulfate is classified

Cleansing Agents

Recommendations for using Sodium Myreth Sulfate during pregnancy and breastfeeding

Limited data suggests no known risk

 

Sodium Myreth Sulfate During Pregnancy

What we know about using Sodium Myreth Sulfate while pregnant or breastfeeding

Limited information available.

Tusing et al. (1960) used 10 males and 10 females from each group in the Sodium Alkylbenzenesulfonate feeding study described earlier for a reproductive and developmental toxicity study. After 14 weeks on the treated feed (0, 0.05%, or 0.1% Sodium Alkylbenzensulfonate), the rats were paired and mated while continuing on the test diet. After 3 days, the males were returned to their original cages; the females were allowed to deliver and nurse for 21 days. They were then returned to their original cages and the pups were fed the parental diet. At ~ 130 d 1 2 ay, the F pups were paired and mated. The F pups were continued on the parental diet for 8 weeks. Sodium Alkylbenzenesulfonate had no observed effects on fertility, litter size, lactation, or survival of offspring. There were no remarkable findings in the hematologic studies, urinalysis, or blood urea nitrogen tests. Gross and microscopic examinations of the offspring were also unremarkable. Alkylbenzenesulfonate Omori et al. (1968) incorporated Alkylbenzenesulfonate (0, 0.25%, 0.1%, 0.5%, 1.0%, or 2.0%) into the diets of pregnant rats (n = 15 [0, 0.25%, and 0.5%], 16 [0.1%], 14 [1.0%], 5 [2.0%]; strain not specified). Dams in the 1.0% and 2.0% groups had diarrhea. No clinical signs were noted in the other groups. Feed intake was decreased in the high-dose group. At necropsy, placenta weights were decreased compared to controls in the high-dose group (0.26 ± 0.01 vs. 0.36 ± 0.01). The number of pups per litter was reduced in the high-dose group (3.6 ± 2.4 vs 10.4 ± 0.7). The number of dead litters and dead pups were increased and the number of resorptions were reduced in the high-dose group. In the high-dose group, body weight, body length, and tail length of the pups were reduced. There were no differences in organ weights of the pups. Mice (n = 22 to 24; strain not specified) were orally administered Alkybenzenesulfonate (0, 24, or 240 mg/kg) on days 7 and 13 of pregnancy. There was a slight decrease in maternal weight gain (80.6, 62.9, 56.3 g, respectively). There were no effects observed on the fetuses from dams in the low-dose group. The number of dead pups increased in the high-dose group. There were no congenital malformations observed in either treatment group (Omori et al. 1968). Linear Alkylbenzenesulfonate Charles River rats that were being used in a chronic toxicity study were concurrently used in a 3-generation reproductive study (Buehler et al. 1971). Twenty male and 20 female rats from each group were fed a diet containing 0, 0.5%, 0.1%, or 0.02% LAS then were mated after being on study for 84 days. There were no effects observed associated with Linear Alkylbenzenesulfonate administration. Palmer et al. (1975a) tested for teratogenic effects of LAS in CD rats (n = 20), CD-1 mice (n = 20), and New Zealand white rabbits (n = 13). Linear Alkylbenzenesulfonate (0, 0.2, 2.0, 300, or 600 mg/kg/d in water) was orally administered from day 6 to day 15 in rats and mice and to day 18 in rabbits. The rats, mice, and rabbits were killed and necropsied on days 20, 17, and 29, respectively. For the mice, 7 dams died in the 300 mg/kg/d group and 18 died in the 600 mg/kg/d group; all others survived. For the rats, only 1 died in the 600 mg/kg/d group. For the rabbits, 1, 11, and 13 died in the 2, 300, and 600 mg/kg/d groups, respectively. The mice in the 300 mg/kg/d group had retarded weight gains and weight loss was observed in the 600 mg/kg/d group. There was retarded weight gains for the rats in the 600 mg/kg/d group. There was weight loss for rabbits in the 300 and 600 mg/kg/d groups. In all species toxic effects of the gastrointestinal tract were observed, especially in the rabbits (diarrhea, anorexia, weight loss, and cachexia prior to death. Total litter loss (abortion and/or total resorption) tended to occur as a secondary consequence. The authors concluded that 300 and 600 mg/kg/d caused marked maternal toxicity or undue interference with maternal economy. At maternally toxic dosages there was increased fetal loss and reduced litter size in rabbits and mice, mostly due to total litter loss. At nontoxic and slight to moderately toxic dosages, values for litter size and fetal loss were unaffected (mice and rabbits, 0.2 and 2.0 mg/kg/d; rat, all dosages). Examination of the fetuses revealed no increase in abnormalities (Palmer et al. 1975a). Pregnant ICR-SLC mice were dosed with 10, 100, or 300 mg/kg Linear Alkylbenzenesulfonate by stomach tube on days 6-15 of gestation (Shiobara and Imahori, 1976). The mice were killed on day 17 and their fetuses examined. Marked maternal and embryonic toxic effects, including maternal death, premature delivery, total litter loss, and high fetal death rate, were observed for mice of the 300 mg/kg dosage group. Maternal body weight gains and fetal body weights were significantly decreased in each of the dose groups. External malformations, such as cleft palate and exencephaly, were observed sporadically for fetuses of the control and dose groups. 20 Sodium Alkylbenzenesulfonate Mixture As described earlier, Freeman et al. (1945) conducted a subchronic toxicity study in which the fertility of the treated rats also was determined. A Sodium Alkylbenzenesulfonate mixture (0.5g/100 g feed) was incorporated into the feed of rats (strain not specified; 21 days old; n = 21) for 65 days. Control rats received the basal diet. According to these authors, the Sodium Alkylbenzenesulfonate mixture had no effect on fertility in rats. Dermal TEA-Dodecylbenzenesulfonate A semipermanent hair dye formulation containing 0.5% TEADodecylbenzenesulfonate was applied dermally to a shaved dorsoscapular area of 20 pregnant Charles River CD rats (Burnett et al. 1976). A dose of 2 ml/kg was applied on days 1, 4, 7, 10, 13, 16, and 19 of gestation. Three negative control groups were shaved but not treated. The rats were killed on day 20 of gestation and the fetuses were examined. No signs of toxicity and no dermal irritation were observed in the treatment groups, other than discoloration of the skin and hair at the test site. There were no differences in body weight gains or feed consumption between the treated and negative control groups. The authors concluded that the test material did not produce embryotoxic or teratogenic effects. Burnett et al. (1981) reported a study in which 25 male SpragueDawley CD rats were dosed dermally with 0.5 ml of a semipermanent hair dye formulation that contained 0.2% to 0.3% TEA-Dodecylbenzenesulfonate twice weekly for 10 weeks . The formulation was applied to a shaved 1 in area on the back of 2 each rat. A second group of 25 male Sprague-Dawley CD rats was untreated and served as a control group. After 10 weeks of dosing, each of the 25 treated male rats was mated with 3 10- week-old female Sprague-Dawley CD rats (1/week for 3 weeks) for a total of 75 mated females per group. The gravid females were allowed to deliver and the number and gender of live and dead pups were recorded. After 4 days, each litter was culled to a maximum of 6 males. Two healthy 21-day-old males were selected from each litter as 1 1 the F males and kept until maturity. After 12 weeks, 100 F males per group were mated with 3 sexually mature females (1/week for 3 weeks). The females were killed on days 14 to 16 of gestation and their uteri and fetuses were examined. There were no differences in body weight gains between the treated and control groups. The level of fertility was high for the initial test males as well as the controls, and the results of the matings of the F1 males were similar for both groups. There were no differences in the number of total and average live pups between the treated and control group. The authors concluded that the test material did not produce any adverse effects on reproduction in male Sprague-Dawley CD rats. Linear Alkylbenzenesulfonate Pregnant ICR-JCL mice were administered dermal applications of 0.5 ml of 0.85%, 1.7%, 2.55%, or 3.4% Linear Alkylbenzenesulfonate solutions on days 1 to 13 of gestation (Masuda et al. 1974). Controls were dosed with distilled water. The number of gravid dams was 20, 21, 16, 17, and 10 for the control, 0.88%, 1.7%, 2.55%, and 3.4% groups, respectively. The final mean body weight of the 10 dams of the 3.4% Linear Alkylbenzenesulfonate group was increased compared to the final mean body weight of 10 dams of the control group. The absolute liver, kidney, and spleen weights were also increased for this group. There was no difference in body weight gain between test and control dams and no visceral defects were observed. Pregnancy rate was decreased in the 3.4% dose group, with a rate of 33.3% as compared to 69.0% for the controls; considerable dermal irritation was observed at the application site. Live fetus growth was decreased in all test groups except for the 1.7% group when compared to the controls. There was no difference in external or internal fetal anomalies. However, the frequency of retarded ossification of sternebrae was 25% and 27% for the 2.55% and 3.4% dose groups, respectively, as compared to 11% for the control group. The authors concluded that there was no conclusive evidence of teratogenic effects. Pregnant ddY mice were administered dermal applications of 0.017%, 0.17%, or 1.7% Linear Alkylbenzenesulfonate solutions on days 2 to 14 of gestation. Two control groups were dosed with distilled water or were untreated. The number of gravid dams was 10, 7, 4, 10, and 5 for the untreated control, 0, 0.017%, 0.17%, and 1.7% groups, respectively. No adverse effects were observed for the test fetuses as compared to the controls. The authors concluded that there was no conclusive evidence of teratogenic effects (Masuda et al. 1974). Palmer et al. (1975b) applied Linear Alkylbenzenesulfonate (0, 0.03%, 0.3%, or 3.0% in distilled water; 0.5 or 10 ml) to the shaved backs of CD-1 mice (n = 20), CD rats (n = 20), and New Zealand white rabbits (n = 13) to test for teraterogenic effects. The mice were treated days 2 to 13 of pregnancy, rats were treated days 2 to 15, and rabbits were treated days 1 to 16. The applications were not occluded or washed. One mouse died in the low-dose group, no rats died during treatment, and 1 rabbit in the mid-dose group died. The mouse and rabbit dams had dermal reactions consisting of erythema and edema with peak response at day 6 to 7. The mice also had dead skin and accumulated test material formed a scabrous layer; the rabbits had cracking and bleeding of the skin. There were minor dermal reactions in the rats. Recovery was evident in rats and rabbits after the peak response was attained. All animals had increasing irritability, with peak hypersensitivity at the same time as the local reactions. There was weight loss or marked weight retardation for mice and rabbits in the high-dose group. There was a decrease in number of litters containing viable young in the high-dose groups. The authors concluded that for the dams, marked toxicity was evident in the high-dose groups of mice and rabbits. Mild toxicity was observed in the mid-dose groups for mice and rabbits and the high-dose group for rats. Litter and mean pup weights were not affected by any dose in any of these species. There were no abnormalities associated with treatment at the low- and mid-dose levels. The high-dose level did not have enough litters for assessment. Daly et al. (1980) tested the reproductive and developmental effects of dermally applied Linear Alkylbenzenesulfonate to clipped pregnant Wistar rats (n = 20 or 21). The test material was 21 Linear Alkylbenzenesulfonate (20.5%), alkylbenzene (0.2%), ash (0.6%), and water (77.7%). The 3 control groups were untreated and unclipped, clipped, or clipped and treated with water. The test groups were treated with the test material (1%, 5%, or 20% in water; 20, 100, or 400 mg/kg/d, respectively) by applying the test material, rubbing it in for 3 min, leaving it on for 30 min, and then rinsing off with water. The other test groups were treated with test material (0.05%, 0.1%, or 0.5%; 1, 2, or 10 mg/kg/d) which was not removed after application. The dams were treated daily from day 0 to 20 of gestation then killed and necropsied. The fetuses were examined for deformities. There were no mortalities during the test period. The mean body weights of the high-dose wash off group were decreased compared to controls for gestation day 12 to 21. Feed consumption was comparable in all groups. There were no cutaneous manifestations in the 0.05%, 0.1%, or 0.5% leave-on groups. There was a light brown skin discoloration in 3 dams on days 3 to 6 of the 1.0% wash-off group, and 14 of 20 dams in the 5.0% wash-off group had slight erythema and dry skin on days 3 to 6 and slight skin thickening in 7 of 20 animals. After day 6, erythema and fissuring were no longer observed. Brown discoloration continued in 1 or 2 animals throughout treatment. The high-dose wash-off group had slight erythema on most dams on days 2 to 4. After day 6, this reaction was no longer observed. There was slight skin thickening at the application site on 2 dams on day 2 and on all dams by day 5. Moderate skin thickening was noted in 6 dams the first half of gestation. Slight fissuring was noted in 18 dams from day 4. Clear exudate and brown skin discoloration were occasionally noted. There were no differences between groups with regards to number of corpora lutea, implantations, viable fetuses, or resorptions. No abnormalities were observed at necropsy. There were no differences among groups of offspring for viability or deformities. The authors concluded that Linear Alkylbenzenesulfonate applied to the skin of pregnant rats (either left on or washed off) elicits skin reactions and decreases maternal body weight but does not have any teratogenic or embryopathic effects (Daly et al. 1980). A 20% Linear Alkylbenzenesulfonate solution (Nomura et al. 1980; Nomura et al. 1987) or a detergent containing a mixture of Linear Alkylbenzenesulfonate (27%) and alcohol sulfate was applied twice daily to the dorsal skin of pregnant JCL:ICR mice during the preimplantation period (days 0-2 of gestation). There was an increase in the number of embryos collected on day 3 that were severely deformed or remained at the morula stage. Most of the abnormal embryos were fragmented or remained at the 1- to 8-cell stages and were either dead or dying. The number of embryos in the oviducts was greater for the mice dosed with Linear Alkylbenzenesulfonate as compared to the control mice used in that study (which were dosed with water). No pathological changes were detected in the major organs of the dams.

General safety info about Sodium Myreth Sulfate from CIR

Sodium Iaureth sulfate is a member of a group of salts of sulfated ethoxylated alcohols, the safety of which was evaluated by the Cosmetic Ingredient Review (CIR) Expert Panel for use in cosmetics. Sodium and ammonium laureth sulfate have not evoked adverse responses in any toxicological testing. Sodium laureth sulfate was demonstrated to be a dermal and ocular irritant but not a sensitizer. The Expert Panel recognized that there are data gaps regarding use and concentration of these ingredients. However, the overall information available on the types of products in which these ingredients are used and at what concentrations indicates a pattern of use. The potential to produce irritation exists with these salts of sulfated ethoxylated alcohols, but in practice they are not regularly seen to be irritating because of the formulations in which they are used. These ingredients should be used only when they can be formulated to be nonirritating

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Products where you might find Sodium Myreth Sulfate

Drunk Elephant B-Hydra Intensive Hydration Serum; Drunk Elephant Lala Retro Whipped Moisturizer with Ceramides; The Ordinary Natural Moisturizing Factors + HA