Sodium Pca

The Basics On Sodium Pca

What is Sodium Pca?

PCA (pyrrolidone carboxylic acid) is a natural component of skin.

What are other names for Sodium Pca?

N/A

What is Sodium Pca used for?

PCA and Sodium PCA increase the water content of the top layers of the skin by drawing moisture from the surrounding air. They also enhance the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.

How Sodium Pca is classified

Skin-Replenishing

Recommendations for using Sodium Pca during pregnancy and breastfeeding

Limited data suggests no known risk

 

Sodium Pca During Pregnancy

What we know about using Sodium Pca while pregnant or breastfeeding

Limited information available.

In the original safety assessment, the Panel was concerned that developmental toxicity data were absent.1 The Panel determined that a safety assessment could be completed, however, if PCA was found not to significantly penetrate the skin. Data were made available indicating that the amount of exogenously applied PCA absorbed through the skin was on the order of 1% of the applied dose, but that up to 5% was distributed between the dermis and epidermis. Concern was expressed over the potential that the PCA adsorbed in the dermis and epidermis would eventually move across the skin and result in a cumulative penetration that could be significant. This concern was mitigated by the low actual penetration through the skin over a 24-hour period and the recognition that PCA is naturally resident in the skin. Additionally, it was noted that adverse effects were absent in a 26-week oral study. With these factors considered, the Expert Panel concluded that the extent of penetration was not significant and that developmental toxicity data were not critical to completion of the safety assessment. Sodium PCA was not a developmental or reproductive toxicant in rats.10 Groups of 12 male and 12 female Wistar rats were dosed by gavage once daily with 0, 62.5, 250, or 1000 mg/kg bw/day sodium PCA in water. The females were dosed for 2 wks prior to mating until day 4 of lactation; the males were dosed for 14 days prior to mating and for 14 days during mating. No adverse effects on any measured parameters in the parents or offspring were observed. The no-observable adverse effect level (NOAEL) for maternal and reproductive toxicity was 1000 mg/kg bw/day

General safety info about Sodium Pca from CIR

No report found.

Use this, not that!

Products where you might find Sodium Pca

The Ordinary Natural Moisturizing Factors + HA; Drunk Elephant F-Balm Electrolyte Waterfacial Mask; Murad AHA/BHA Exfoliating Cleanser