Tridecyl Trimellitate

The Basics On Tridecyl Trimellitate

What is Tridecyl Trimellitate?

Used as a skin-conditioning agent and thickening agent. 

What are other names for Tridecyl Trimellitate?

1,2,4-BENZENETRICARBOXYLIC ACID, TRITRIDECYL ESTER, 1,2,4BENZENETRICARBOXYLIC ACID, MIXED BRANCHED TRIDECYL ANDISODECYL ESTERS, TRIDECYL TRIMELLITATE, and TRITRIDECYL ESTER 1,2,4-BENZENETRICARBOXYLIC ACID

What is Tridecyl Trimellitate used for?

A viscous, thick liquid emollient that gives lubricity and cushion at low use levels. It’s great for night creams, eye area products, and skin treatment products due to the substantive film forming ability.

How Tridecyl Trimellitate is classified

Thickeners/Emulsifiers, Texture Enhancer, Hydration, Skin-Softening

Recommendations for using Tridecyl Trimellitate during pregnancy and breastfeeding

Limited data suggests no known risk

 

Tridecyl Trimellitate During Pregnancy

What we know about using Tridecyl Trimellitate while pregnant or breastfeeding

Limited information available.

In an oral developmental toxicity study, tricaprylyl/capryl trimellitate had a NOAEL of 300 mg/kg bw/day for maternal toxicity and of 1000 mg/kg bw/day for fetotoxicity in rats dosed with up to 1000 mg/kg/day on days 6-15 of gestation29(Table 7). In a reproductive and developmental toxicity study, orally administered triethylhexyl trimellitate had a no-observed effect level (NOEL) of 100 mg/kg/day in male rats and 1000 mg/kg/day in female rats and offspring; spermatocytes and spermatids were decreased with doses of 300 and 1000 mg/kg/day.32 Two oral developmental toxicity studies with triethylhexyl trimellitate in rats (by gavage with up to 1000 and 1050 mg/kg bw/day on days 14-18 and 6-19 of gestation, respectively) did not produce any toxicologically significant effects.32,46 Neither tricaprylyl/capryl trimellitate nor triethyl-hexyl trimellitate, at doses of 500 mg/kg bw/day, had a significant repressive effect on genes in the testicular mal-develop-ment (TMD) pathway.29,32In Vitro Tests for Endocrine ActivityTriethylhexyl TrimellitateTriethylhexyl trimellitate was screened in an in vitro competitive binding assay measuring its binding affinity for the human estrogen receptor alpha (ERα).47 Triethylhexyl trimellitate in dimethyl sulfoxide (DMSO; 10-10 to 10-4 mol/l) had no affinity for ERα in this assay. It also did not have estrogenic activity in a yeast two-hybrid assay (an assay based on the ligand-dependent interaction of ERα and the coactivator TIF2) at final concentrations of 10-3 to 10-7 mol/l in DMSO.48 The 10% relative effective concentration (i.e., the concentration producing 10% of the agonist activity of the highest activity level of17 β-estradiol; REC10) was >0.001 mmol/l triethylhexyl trimellitate. The estrogenic activity of the metabolites of triethyl-hexyl trimellitate (which were not identified) was also measured; the metabolite solution was prepared by incubating triethyl-hexyl trimellitate in S9 mix. The REC10 of the metabolite solution was >0.0005 mmol/l. Triethylhexyl trimellitate in DMSO did exhibit estrogenic activity in an in vitro test using human osteoblastic (US-O2) reporter gene cell lines forERα and ERβ.49 The lowest effective concentrations of triethylhexyl trimellitate in the ERα and ERβ reporter cells were 8.1 and 4.9 μM, respectively. The estradiol equivalence factors (EEF10; i.e., EC10 estradiol/EC10 triethylhexyl trimellitate) in theERα and ERβ were 1.2 x 10-7 and 1.6 x 10-6, respectively; the EEF10α/EEF10β ratio was 0.0075.When compared to estradiol, the maximum estrogenic effect of triethylhexyl trimellitate in ERα cells was 113% of that found with estradiol, and in the ERβ cells, it was 76% of that found with estradiol.

General safety info about Tridecyl Trimellitate from CIR

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 5 trialkyl trimellitates. These ingredients, which are all structurally related as alkyl esters of trimellitic acid, are reported to function in cosmetics as skin conditioning agents; 2 of the ingredients are also reported to function in cosmetics as plasticizers. The Panel reviewed the available data to determine the safety of these ingredients, and concluded that the trialkyl trimellitates are safe in the current practices of use and concentration when formulated to be non-irritating

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Products where you might find Tridecyl Trimellitate

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