Triethoxycaprylylsilane Crosspolymer

The Basics On Triethoxycaprylylsilane Crosspolymer

What is Triethoxycaprylylsilane Crosspolymer?

A silicone polymer used to enhance a product’s texture.

What are other names for Triethoxycaprylylsilane Crosspolymer?

DIMETHOXYDIPHENYLSILANE/TRIETHOXYCAPRYLYLSILANE CROSSPOLYMER

What is Triethoxycaprylylsilane Crosspolymer used for?

Its chief function as to enhance the texture and slip of cosmetic products.

How Triethoxycaprylylsilane Crosspolymer is classified

Silicones, Film-Forming/Holding Agents

Recommendations for using Triethoxycaprylylsilane Crosspolymer during pregnancy and breastfeeding

Limited data suggests no known risk

 

Triethoxycaprylylsilane Crosspolymer During Pregnancy

What we know about using Triethoxycaprylylsilane Crosspolymer while pregnant or breastfeeding

Limited information available.

TriethoxycaprylylsilaneAs stated previously, Triethoxycaprylylsilane (0, 100, 300 or 1000 mg/kg/d in dried, de-acidified peanut oil) was administered 7 days a week by gavage to 10 rats/sex/group for up to 45 consecutive days in a combined repeated-dose/reproductive/developmental toxicity screening test.5 The study was in accordance with OECD TG 422. Females were divided into a repeated-toxicity group and a reproductive-toxicity group. The same males were used for both the repeated-dose toxicity and reproductive-toxicity phases of the study. Males were treated for 28 days. Reproductive-toxicity group females were treated for up to 45 days (14 days prior to mating, during mating, gestation, and up to and including postpartum day 4). Mating was initiated after 2 weeks of dosing. Females in the reproductive-toxicity group cohabitated with males of the same treatment group until positive evidence of mating occurred. A maximum of 14 days were allowed for mating. Reproductive parameters evaluated included evidence of mating, pregnancy, duration of gestation, mean number of corpora lutea and mean number of uterine implantation sites, mean mating and fertility indices and evaluation of loss of offspring (pre-implantation and post-natal loss). [See results specific to toxicity in the Short-Term Toxicity Studies section.]Changes in reproductive parameters were observed in the high-dose group and were associated with marked maternal toxicity. Mating and fertility were unaffected by treatment. The mean duration of gestation was increased (5.6%) compared to the control group. Of the seven dams that successfully initiated parturition, four exhibited dystocia (difficult/prolonged labor). The authors concluded that it was not possible to determine with confidence if 1000 mg/kg/d represents the NOAEL. Therefore, the reproductive toxicity NOAEL was considered to be >300 mg/kg/d.To evaluate the developmental toxicity of Triethoxycaprylylsilane, dams and pups were killed on postpartum day 4 and examined for external gross lesions. Developmental parameters evaluated included total litter size, mean litter size, mean live litter size, mean litter weight, mean ratio of live births/litter size, sex ratio, pup viability, pup body weight, and body weight gain. Changes in developmental parameters were observed in the high-dose group and were associated with marked maternal toxicity; the total litter sizes in this group were unaffected by treatment but the mean number of live male and female pups/dam at first litter check on post-natal day (PND) 0 was decreased (39.3%) compared to controls. PND 0 mean litter weights, average pup body weights and body weight gains were similar to controls. By PND 4, several dams in the high-dose group had been killed due to the severity of various clinical signs and/or difficulty during labor. Only 4 dams survived to PND 4. Of these litters, the total viable pups on PND 4 were decreased compared to controls, resulting in a 25.2% decrease in percent viability of pups/dam on PND 4 compared to controls. This decrease was due to a single dam with a 14.3% post-natal loss of offspring. The remaining dams had no post-natal loss of pups between Days 0-4. PND 4 mean litter weights, average pup body weights and body weight gains in the high-dose group were also decreased compared to controls. External gross lesions were not observed for treated dams or pups. The authors concluded that it was not possible to determine with confidence if 1000 mg/kg/d represents the NOAEL. Therefore, they considered the developmental toxicity NOAEL to be >300 mg/kg/d.

General safety info about Triethoxycaprylylsilane Crosspolymer from CIR

This is a safety assessment of alkoxyl alkyl silanes as used in cosmetics. The functions of these ingredients include: binder, skin-conditioning agent – miscellaneous, skin-conditioning agent – emollient, and surface modifier. The Cosmetic Ingredient Review (CIR) Expert Panel reviewed relevant data related to these ingredients. The Panel concluded that Bis-Stearoxydimethylsilane, Stearoxytrimethylsilane, Triethoxycaprylylsilane, and Trimethoxycaprylylsilane are safe as cosmetic ingredients in the practices of use and concentration described in this safety assessment.

Use this, not that!

Products where you might find Triethoxycaprylylsilane Crosspolymer

The Ordinary Hyaluronic Acid 2% + B5; Drunk Elephant Lala Retro Whipped Moisturizer with Ceramides; Drunk Elephant Been A Long Day Glycolic Serum + Moisturizer Duo