Argatroban

The Basics

What is Argatroban?

Anticoagulant licensed for treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT).

Brand names for Argatroban

Argatroban

How Argatroban is classified

Anticoagulants, Antithrombins

Argatroban During Pregnancy

Argatroban pregnancy category

Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Argatroban while pregnant

Limited data from published literature and postmarketing reports do not suggest an association between argatroban and adverse fetal developmental outcomes. There are risks to the mother associated with untreated thrombosis in pregnancy and risk of hemorrhage in the mother and fetus associated with the use of anticoagulations (see Clinical Considerations). In animal reproductive studies, there was no evidence of adverse developmental outcomes with intravenous administration of argatroban during organogenesis in rats and rabbits at doses up to 0.3-and 0.2-times, respectively, the maximum recommended human dose (MHRD) (see Data). The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2%-4% and 15%-20%, respectively. Clinical Considerations Disease-Associated Maternal And/Or Embryo/Fetal Risk Pregnancy confers an increased risk for thromboembolism that is higher for women with underlying thromboembolic disease and certain high risk pregnancy conditions. Published data describe that women with a previous history of venous thrombosis are at high risk for recurrence during pregnancy. Fetal/Neonatal Adverse Reactions Use of anticoagulants, including argatroban, may increase the risk of bleeding in the fetus and neonate. Monitor neonates for bleeding .

Taking Argatroban While Breastfeeding

What are recommendations for lactation if you're taking Argatroban?

Because no information is available on the use of argatroban during breastfeeding, an alternate drug is preferred.[1]

Maternal / infant drug levels

Because no information is available on the use of argatroban during breastfeeding, an alternate drug is preferred.[1]

Possible effects of Argatroban on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Argatroban

Acenocoumarol, Dalteparin, Enoxaparin, Heparin, Warfarin.