The Basics
What is Lisuride?
antiparkinson agent of the iso-ergoline class
Brand names for Lisuride
Dopergin, Proclacam, And Revanil
How Lisuride is classified
Antiparkinson Agents, Dopamine Agonists, Serotonin Receptor Agonists
Lisuride During Pregnancy
Lisuride pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Lisuride while pregnant
N/A
Taking Lisuride While Breastfeeding
What are recommendations for lactation if you're taking Lisuride?
Lisuride is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. It lowers serum prolactin and is approved in some countries for lactation suppression. Some experts recommend lisuride as a safer alternative to bromocriptine for lactation suppression, but others recommend avoiding all lactation suppressants.[1][2] Data are insufficient recommend one treatment for lactation suppression over another.[3]
Maternal / infant drug levels
Lisuride is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. It lowers serum prolactin and is approved in some countries for lactation suppression. Some experts recommend lisuride as a safer alternative to bromocriptine for lactation suppression, but others recommend avoiding all lactation suppressants.[1][2] Data are insufficient recommend one treatment for lactation suppression over another.[3]
Possible effects of Lisuride on milk supply
Lisuride suppresses serum prolactin increases in a dose-related fashion.[4][5] Comparative studies have found lisuride comparable in efficacy to bromocriptine, although rebound lactation occurred in more patients treated with lisuride 0.4 mg daily than in those treated with bromocriptine 5 mg daily.[6][7] Rebound lactation appears to be less with a higher dose of 0.6 mg daily and with 15 days of therapy rather than 10 days.[8][9]
Possible alternatives to Lisuride
(Hyperprolactinemia) Bromocriptine, Cabergoline.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Marcellin L, Chantry AA. [Breast-feeding (part II): Lactation inhibition–Guidelines for clinical practice]. J Gynecol Obstet Biol Reprod (Paris). 2015;44:1080-3. PMID: 26527027
2. Anon. Do not use drugs to delay the onset of lactation. Relieve the discomfort and wait. Prescrire Int. 2012;32:918-20. PMID: 23951598
3. Oladapo OT, Fawole B. Treatments for suppression of lactation. Cochrane Database Syst Rev. 2012;9:CD005937. PMID: 22972088
4. Hardt W, Schmidt-Gollwitzer M, Horowski R. Suppression of lactation with lisuride. Gynecol Obstet Invest. 1979;10:95-105. PMID: 535777
5. De Cecco L, Venturine PL, Ragni N et al. Effect of lisuride on inhibition of lactation and serum prolactin. Br J Obstet Gynaecol. 1979;86:905-8. PMID: 508675
6. Bohnet HG, Kato K, De Moll H. Prolactin stimulation tests: Different response patterns after bromocriptine, lisuride, and metergoline treatment of puerperal women. Obstet Gynecol. 1988;71:53-5. PMID: 3336541
7. Van Dam LJ, Rolland R. Lactation-inhibiting and prolactin-lowering effect of lisuride and bromocriptine: A comparative study. Eur J Obstet Gynecol Reprod Biol. 1981;12:323-30. PMID: 7333409
8. Sereno Colo JA, Navarrete Horta MT. [Inhibition of lactation with lisuride. Clinical evaluation]. Ginecol Obstet Mex. 1994;62:31-4. PMID: 8168721
9. Strahl HJ, Goretzlehner G, Strahl S et al. [Lactation inhibition with various dosages of lisuride–prolactin secretion and effectiveness]. Zentralbl Gynakol. 1985;107:300-3. PMID: 4039514
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
