The Basics
What is Loxapine?
Used to treat the symptoms of schizophrenia.
Brand names for Loxapine
Loxapine
How Loxapine is classified
Antipsychotic Agents
Loxapine During Pregnancy
Loxapine pregnancy category
Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Loxapine while pregnant
N/A
Taking Loxapine While Breastfeeding
What are recommendations for lactation if you're taking Loxapine?
Because no information is available on the use of loxapine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Maternal / infant drug levels
Because no information is available on the use of loxapine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Possible effects of Loxapine on milk supply
Loxapine can elevate serum prolactin.[2] The hyperprolactinemia is caused by the drug’s dopamine-blocking action in the tuberoinfundibular pathway.[3]
The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Possible alternatives to Loxapine
Haloperidol, Olanzapine.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Meltzer HY, Fang VS, Goode DJ. Prolactin and neuroleptics: clinical implications for efficacy and toxicity. The effect of neuroleptics and alpha-methyl-para-tyrosine on serum prolactin levels in laboratory animals and man. Psychopharmacol Bull. 1978;14:5-7. PMID: 625539
2. Maguire GA. Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences. J Clin Psychiatry. 2002;63(suppl 4):56-62. PMID: 11913677
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
