Nabumetone

The Basics

What is Nabumetone?

Used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis.

Brand names for Nabumetone

Relafen

How Nabumetone is classified

Analgesic Agents, Nonsteroidal Antiinflammatory Agents

Nabumetone During Pregnancy

Nabumetone pregnancy category

Category CNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Nabumetone while pregnant

Nabumetone did not cause any teratogenic effect in rats given up to 400 mg/kg (2,360 mg/m2 ) and in rabbits up to 300 mg/kg (3,540 mg/m2 ) orally; however, increased post-implantation loss was observed in rats at 100 mg/kg (590 mg/m2 ) orally and at higher doses (equal to the average human exposure to 6MNA at the maximum recommended human dose). There are no adequate, well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Because of the known effect of prostaglandin-synthesis-inhibiting drugs on the human fetal cardiovascular system (closure of ductus arteriosus), use of RELAFEN during the third trimester of pregnancy is not recommended.

Taking Nabumetone While Breastfeeding

What are recommendations for lactation if you're taking Nabumetone?

Because no information is available on the use of nabumetone during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.

Maternal / infant drug levels

Because no information is available on the use of nabumetone during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.

Possible effects of Nabumetone on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Nabumetone

Acetaminophen, Flurbiprofen, Ibuprofen, Indomethacin, Naproxen, Piroxicam.