The Basics
What is Ticarcillin and Clavulanic Acid?
A combination medicine used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, stomach infections, skin infections, and others.
Brand names for Ticarcillin and Clavulanic Acid
Timentin
How Ticarcillin and Clavulanic Acid is classified
Anti-Infective Agents, Antibacterial Agents, Penicillins
Ticarcillin and Clavulanic Acid During Pregnancy
Ticarcillin and Clavulanic Acid pregnancy category
Category BNote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Ticarcillin and Clavulanic Acid while pregnant
Reproduction studies have been performed in rats given doses up to 1,050 mg/kg/day and have revealed no evidence of impaired fertility or harm to the fetus due to TIMENTIN. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Taking Ticarcillin and Clavulanic Acid While Breastfeeding
What are recommendations for lactation if you're taking Ticarcillin and Clavulanic Acid?
Limited information indicates that ticarcillin produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Clavulanic acid has not been studied in nursing mothers. Occasionally disruption of the infant’s gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Ticarcillin and clavulanic acid is acceptable is acceptable in nursing mothers.
Maternal / infant drug levels
Limited information indicates that ticarcillin produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Clavulanic acid has not been studied in nursing mothers. Occasionally disruption of the infant’s gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Ticarcillin and clavulanic acid is acceptable is acceptable in nursing mothers.
Possible effects of Ticarcillin and Clavulanic Acid on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Ticarcillin and Clavulanic Acid
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Matsuda S, Tanno M, Kashiwakura T et al. Laboratory and clinical use of ticarcillin. Chemotherapy (Tokyo). 1977;25:2924-31.
2. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. PMID: 6743732
3. Cho N, Nakayama T, Uehara K et al. Laboratory and clinical evaluation of ticarcillin in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1977;25:2911-23.
4. von Kobyletzki D, Dalhoff A, Lindemeyer H et al. Ticarcillin serum and tissue concentrations in gynecology and obstetrics. Infection. 1983;11:144-9. PMID: 6885173
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
