The Basics
What is Betrixaban?
Used to prevent venous thromboembolism (VTE) in hospitalized patients at risk for blood clots.
Brand names for Betrixaban
Bevyxxa
How Betrixaban is classified
Anticoagulants, Antithrombins
Betrixaban During Pregnancy
Betrixaban pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Betrixaban while pregnant
There are no data with the use of BEVYXXA in pregnant women, but treatment is likely to increase the risk of hemorrhage during pregnancy and delivery (see Clinical Considerations). Betrixaban was studied in reproductive and developmental toxicology studies in rats and rabbits during the period of organogenesis at exposures up to 44 times the recommended clinical dose of 80 mg daily. Although betrixaban was not associated with adverse developmental fetal outcomes in animals, maternal toxicity (i.e., hemorrhage) was identified in these studies (see Data). BEVYXXA should be used during pregnancy only if the potential benefit outweighs the potential risk to the mother and fetus. Adverse outcomes in pregnancy occur regardless of the health of the mother or the use of medications. The background risk of major birth defects and miscarriage for the indicated population is unknown. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively.
Taking Betrixaban While Breastfeeding
What are recommendations for lactation if you're taking Betrixaban?
Because no information is available on the use of betrixaban during breastfeeding and the drug is orally absorbable, an alternate drug is preferred while nursing a newborn or preterm infant.[1][2][3]
Maternal / infant drug levels
Because no information is available on the use of betrixaban during breastfeeding and the drug is orally absorbable, an alternate drug is preferred while nursing a newborn or preterm infant.[1][2][3]
Possible effects of Betrixaban on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Betrixaban
Dalteparin, Enoxaparin, Heparin, Warfarin.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Bates SM, Greer IA, Middeldorp S et al. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141 (2 Suppl):e691S-736S. PMID: 22315276
2. Vanassche T, Vandenbriele C, Peerlinck K, Verhamme P. Pharmacotherapy with oral Xa inhibitors for venous thromboembolism. Expert Opin Pharmacother. 2015;16:645-58. PMID: 25554350
3. Cohen H, Arachchillage DR, Beyer-Westendorf J et al. Direct oral anticoagulants and women. Semin Thromb Hemost. 2016. PMID: 27706531
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
