The Basics
What is Polythiazide?
A thiazide diuretic.
Brand names for Polythiazide
Renese
How Polythiazide is classified
Antihypertensive Agents, Thiazide Diuretics
Polythiazide During Pregnancy
Polythiazide pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Polythiazide while pregnant
Thiazides cross the placental barrier and appear in cord blood. The use of thiazides in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus. These hazards include fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions which have occurred in the adult.
Taking Polythiazide While Breastfeeding
What are recommendations for lactation if you're taking Polythiazide?
No information is available on the amount of polythiazide in breastmilk. Intense diuresis with large doses may decrease breastmilk production. Other diuretics in low doses are preferred over polythiazide.
Maternal / infant drug levels
No information is available on the amount of polythiazide in breastmilk. Intense diuresis with large doses may decrease breastmilk production. Other diuretics in low doses are preferred over polythiazide.
Possible effects of Polythiazide on milk supply
Polythiazide 2 mg was given twice daily for 8 days beginning within 24 hours of delivery to suppress postpartum lactation. Patients also had breast binding for at least 10 days and fluid restriction. The authors reported that this technique was effective in 124 cases reviewed.[1] There are no data on the effects of diuretics on established lactation.
Possible alternatives to Polythiazide
Chlorothiazide, Hydrochlorothiazide.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Timmermans HL. [Use of P 2525 or polythiazide as suppressor of lactation during post-partum]. Brux Med. 1963;43:1051-6. PMID: 14095820
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
