The Basics
What is Evolocumab?
An antibacterial prescription medicine that treats infections like acute exacerbations of chronic bronchitis, urinary tract infections, and acute ear infections.
Brand names for Evolocumab
Repatha
How Evolocumab is classified
Antibodies – Monoclonal, Anticholesteremic Agents, Antilipemic Agents
Evolocumab During Pregnancy
Evolocumab pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Evolocumab while pregnant
N/A
Taking Evolocumab While Breastfeeding
What are recommendations for lactation if you're taking Evolocumab?
No information is available on the clinical use of evolocumab during breastfeeding. Because evolocumab is a large protein molecule with a molecular weight of 144,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant’s gastrointestinal tract. Until more data become available, evolocumab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. Evolocumab is a human immunoglobulin G2 (IgG2) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG2 activity decreasing by about 50%.[3] None of the studies measured IgG activity.
Maternal / infant drug levels
No information is available on the clinical use of evolocumab during breastfeeding. Because evolocumab is a large protein molecule with a molecular weight of 144,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant’s gastrointestinal tract. Until more data become available, evolocumab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. Evolocumab is a human immunoglobulin G2 (IgG2) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG2 activity decreasing by about 50%.[3] None of the studies measured IgG activity.
Possible effects of Evolocumab on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Evolocumab
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Koenig A, de Albuquerque Diniz EM, Barbosa SF et al. Immunologic factors in human milk: The effects of gestational age and pasteurization. J Hum Lact. 2005;21:439-43. PMID: 16280560
2. Adhisivam B, Vishnu Bhat B, Rao K et al. Effect of Holder pasteurization on macronutrients and immunoglobulin profile of pooled donor human milk. J Matern Fetal Neonatal Med. 2018;1-4. PMID: 29587541
3. Rodriguez-Camejo C, Puyol A, Fazio L et al. Antibody profile of colostrum and the effect of processing in human milk banks: Implications in immunoregulatory properties. J Hum Lact. 2018;34:137-47. PMID: 28586632
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
