The Basics
What is Imipenem and Cilastatin?
Antibiotic useful for the treatment of a number of bacterial infections.
Brand names for Imipenem and Cilastatin
N/A
How Imipenem and Cilastatin is classified
Anti-Infective Agents, Antibacterial Agents, Carbapenems
Imipenem and Cilastatin During Pregnancy
Imipenem and Cilastatin pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Imipenem and Cilastatin while pregnant
N/A
Taking Imipenem and Cilastatin While Breastfeeding
What are recommendations for lactation if you're taking Imipenem and Cilastatin?
Limited information indicates that imipenem produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant’s gastrointestinal flora, resulting in diarrhea or thrush has been reported with beta-lactams, but these effects have not been adequately evaluated. Imipenem-cilastatin and imipenem-cilastatin-relebactam are acceptable in nursing mothers.
Maternal / infant drug levels
Limited information indicates that imipenem produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant’s gastrointestinal flora, resulting in diarrhea or thrush has been reported with beta-lactams, but these effects have not been adequately evaluated. Imipenem-cilastatin and imipenem-cilastatin-relebactam are acceptable in nursing mothers.
Possible effects of Imipenem and Cilastatin on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Imipenem and Cilastatin
None listed
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Ito K, Izumi K, Takagi H et al. [Fundamental and clinical evaluation of imipenem/cilastatin sodium in the perinatal period]. Jpn J Antibiot. 1988;41:1778-85. PMID: 3210308
2. Matsuda S, Suzuki M, Oh K et al. [Pharmacokinetic and clinical studies on imipenem/cilastatin sodium in the perinatal period. A study of imipenem/cilastatin sodium in the perinatal co-research group]. Jpn J Antibiot. 1988;41:1731-40. PMID: 3062205
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
