The Basics
What is Plecanatide?
Used in adults to treat chronic idiopathic constipation and irritable bowel syndrome with constipation.
Brand names for Plecanatide
Trulance
How Plecanatide is classified
Gastrointestinal Agents, Peptides, Guanylyl Cyclase C Agonists, Laxatives
Plecanatide During Pregnancy
Plecanatide pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Plecanatide while pregnant
N/A
Taking Plecanatide While Breastfeeding
What are recommendations for lactation if you're taking Plecanatide?
No information is available on the use of plecanatide during breastfeeding. Plecanatide is minimally absorbed from the gastrointestinal tract and the drug and its active metabolite is not measurable in plasma following administration of recommended doses. Plecanatide would not be expected to enter the breastmilk and cause any adverse effects in breastfed infants.
Maternal / infant drug levels
No information is available on the use of plecanatide during breastfeeding. Plecanatide is minimally absorbed from the gastrointestinal tract and the drug and its active metabolite is not measurable in plasma following administration of recommended doses. Plecanatide would not be expected to enter the breastmilk and cause any adverse effects in breastfed infants.
Possible effects of Plecanatide on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Plecanatide
(Irritable Bowel Syndrome) Linaclotide, Lubiprostone, Polyethylene Glycol, Psyllium.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/None listed
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
