The Basics
What is Siponimod?
Used to treat the relapsing forms of multiple sclerosis (MS).
Brand names for Siponimod
Mayzent
How Siponimod is classified
Immunosuppressive Agents
Siponimod During Pregnancy
Siponimod pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Siponimod while pregnant
N/A
Taking Siponimod While Breastfeeding
What are recommendations for lactation if you're taking Siponimod?
Although siponimod is highly bound in maternal plasma and unlikely to reach the breastmilk in large amounts, it is potentially toxic to the breastfed infant. Because there is no published experience with siponimod during breastfeeding, expert opinion generally recommends that the closely related drug fingolimod should be avoided during breastfeeding, especially while nursing a newborn or preterm infant.[1][2][3][4][5] However, the manufacturer’s labeling does not recommend against the use of siponimod in breastfeeding.
Maternal / infant drug levels
Although siponimod is highly bound in maternal plasma and unlikely to reach the breastmilk in large amounts, it is potentially toxic to the breastfed infant. Because there is no published experience with siponimod during breastfeeding, expert opinion generally recommends that the closely related drug fingolimod should be avoided during breastfeeding, especially while nursing a newborn or preterm infant.[1][2][3][4][5] However, the manufacturer’s labeling does not recommend against the use of siponimod in breastfeeding.
Possible effects of Siponimod on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Siponimod
(Multiple Sclerosis) Glatiramer, Immune Globulin, Interferon Beta.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Bove R, Alwan S, Friedman JM et al. Management of multiple sclerosis during pregnancy and the reproductive years: a systematic review. Obstet Gynecol. 2014;124:1157-68. PMID: 25415167
2. Cree BA. Update on reproductive safety of current and emerging disease-modifying therapies for multiple sclerosis. Mult Scler. 2013;19:835-43. PMID: 23319073
3. Houtchens MK, Kolb CM. Multiple sclerosis and pregnancy: Therapeutic considerations. J Neurol. 2013;260:1202-14. PMID: 22926165
4. Almas S, Vance J, Baker T et al. Management of multiple sclerosis in the breastfeeding mother. Mult Scler Int. 2016;2016:6527458. PMID: 26966579
5. Kaplan TB . Management of demyelinating disorders in pregnancy. Neurol Clin. 2019;37:17-30. PMID: 30470273
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
