The Basics
What is Sulfisoxazole?
Used to treat certain ear infections caused by bacteria.
Brand names for Sulfisoxazole
Gantrisin
How Sulfisoxazole is classified
Anti-Infective Agents, Antibacterial Agents, Sulfonamides
Sulfisoxazole During Pregnancy
Sulfisoxazole pregnancy category
Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.
What we know about taking Sulfisoxazole while pregnant
N/A
Taking Sulfisoxazole While Breastfeeding
What are recommendations for lactation if you're taking Sulfisoxazole?
With healthy, fullterm infants it appears acceptable to use sulfisoxazole during breastfeeding after the newborn period.[1][2] Until further data are accumulated, alternate agents should probably be used in jaundiced, ill, stressed or premature infants, because of the risk of bilirubin displacement and kernicterus. Sulfisoxazole should be avoided while breastfeeding a glucose-6-phosphate dehydrogenase (G6PD) deficient infant.
Maternal / infant drug levels
With healthy, fullterm infants it appears acceptable to use sulfisoxazole during breastfeeding after the newborn period.[1][2] Until further data are accumulated, alternate agents should probably be used in jaundiced, ill, stressed or premature infants, because of the risk of bilirubin displacement and kernicterus. Sulfisoxazole should be avoided while breastfeeding a glucose-6-phosphate dehydrogenase (G6PD) deficient infant.
Possible effects of Sulfisoxazole on milk supply
Relevant published information was not found as of the revision date.
Possible alternatives to Sulfisoxazole
Sulfamethoxazole, Trimethoprim-Sulfamethoxazole.
List of References
Lactation sources: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/1. Kauffman RE. Sulfisoxazole in human milk. Reply. J Pediatr. 1981;99:172-3.
2. Chung AM, Reed MD, Blumer JL. Antibiotics and breast-feeding: a critical review of the literature. Paediatr Drugs. 2002;4:817-37. PMID: 12431134
3. Kauffman RE, O’Brien C, Gilford P. Sulfisoxazole secretion into human milk. J Pediatr. 1980;97:839-41. PMID: 7431180
4. Elliott GT, Quinn SL. Sulfisoxazole in human milk. J Pediatr. 1981;99:171-3. Letter. PMID: 7252664
Disclaimer: This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Consult your healthcare provider with any questions.
